Asian Pacific Journal of Cancer Prevention

  • 제15권6호
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  • Pages.2517-2522
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  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Association Between the Pre-mir-218 Polymorphism and Cancer Risk in the Chinese Population: a Meta-Analysis

  • Gao, Yue (Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Liu, Yan (Cardiac and Vascular Intensive Care Unit Washington Adventist Hospital) ;
  • Liu, Ge-Li (Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Ran, Long-Ke (Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Zeng, Fan (Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Wu, Jia-Yan (Molecular Medicine and Cancer Research Center, Chongqing Medical University) ;
  • Song, Fang-Zhou (Molecular Medicine and Cancer Research Center, Chongqing Medical University)
  • 발행 : 2014.03.30
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초록

Background: Several recent studies have explored associations between pre-mir-218 polymorphism (rs11134527) and cancer risk. However, published data are still inconclusive. To obtain a more precise estimation of the relationship in the Chinese population, we carried out a meta-analysis for the first time. Materials and Methods: Through retrieval from the PubMed, Medline, Embase, Web of Science databases, China National Knowledge Infrastructure and the Chinese BioMedical Literature Database, a total of four studies were analyzed with 3,561 cases and 3,628 controls for SNP pre-mir-218 rs11134527. We calculated odds ratios (ORs) and 95% confidence intervals (95%CIs) to explore the strength of associations. Results: The results showed that the rs11134527 polymorphism was associated with decreased cancer risk in GG versus AA and GG versus AA+AG models tested ( GG vs AA: OR=0.82, 95%CI: 0.71-0.94; GG vs AA+AG: OR=0.84, 95%CI: 0.74-0.96), and significantly decreased cervical cancer risk was observed in GG versus AA and GG versus AA+AG models (GG vs AA: OR=0.79, 95%CI: 0.66-0.94; GG vs AA+AG: OR=0.80, 95%CI: 0.68-0.94). However, no significant association between the rs11134527polymorphism and hepatocellular carcinoma risk was observed in all comparison models tested (AG vs AA: OR=0.94, 95%CI: 0.79-1.11; GG vs AA: OR=0.88, 95%CI: 0.70-1.10; GG+AG vs AA: OR=0.92, 95%CI: 0.79-1.08; GG vs AA+AG: OR=0.91, 95%CI: 0.75-1.11). Conclusion: The findings suggest that pre-miR-218 rs11134527 polymorphism may have some relation to cancer development in Chinese. However, well-designed studies with larger sample size and more detailed data are needed to confirm these conclusions.

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참고문헌

  1. Anglicheau D, Muthukumar T, Suthanthiran M (2010). MicroRNAs: small RNAs with big effects. Transplantation, 90, 105-12.
  2. Alajez NM, Lenarduzzi M, Ito E, et al (2011). MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway. Cancer Res, 71, 2381-91. https://doi.org/10.1158/0008-5472.CAN-10-2754
  3. Bartel DP (2009). MicroRNAs: target recognition and regulatory functions. Cell, 136, 215-33. https://doi.org/10.1016/j.cell.2009.01.002
  4. Chen K, Song F, Calin GA, et al (2008). Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. Carcinogenesis, 29, 1306-11. https://doi.org/10.1093/carcin/bgn116
  5. Chen AX, Yu KD, Fan L, et al (2011). Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility. PLoS Genet, 7, 1002259. https://doi.org/10.1371/journal.pgen.1002259
  6. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-88 . https://doi.org/10.1016/0197-2456(86)90046-2
  7. Davidson MR , Larsen JE , Yang IA , et al (2010). MicroRNA-218 is deleted and downregulated in lung squamous cell carcinoma. PLoS One, 5, 12560. https://doi.org/10.1371/journal.pone.0012560
  8. Esquela-Kerscher A, Slack FJ (2006). Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer, 6, 259-69 https://doi.org/10.1038/nrc1840
  9. He L, Hannon GJ (2004). MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet, 5, 522-31. https://doi.org/10.1038/nrg1379
  10. Han Y, Pu R, Han X, et al (2013). Association of a potential functional pre-miR-218 polymorphismand its interaction with hepatitis B virusmutations with hepatocellular carcinoma risk. Liver Int. [Epub ahead of print]
  11. Higgins JP, Thompson SG (2002). Thompson SG Quantifying heterogeneity in a meta-analysis. Stat Med, 21, 1539-58. https://doi.org/10.1002/sim.1186
  12. Kutanzi KR , Yurchenko OV, Beland FA, et al (2011). MicroRNAmediated drug resistance in breast cancer. Clin Epigenetics, 2, 171-85. https://doi.org/10.1007/s13148-011-0040-8
  13. Link A, Kupcinskas J, Wex T, et al (2012). Macro-role of microRNA in gastric cancer. Dig Dis, 30, 255-67. https://doi.org/10.1159/000336919
  14. Liu Z, Wei S, Ma H, et al (2011). A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck. Carcinogenesis, 32, 1668-74. https://doi.org/10.1093/carcin/bgr209
  15. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 22, 719-48.
  16. Martinez I, Gardiner AS, Board KF, et al (2008). Human papillomavirus type 16 reduces the expression of microRNA-218 in cervical carcinoma cells. Oncogene, 27, 2575-82. https://doi.org/10.1038/sj.onc.1210919
  17. Petrocca F, Visone R, Onelli MR, et al (2008). E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer. Cancer Cell, 13, 272-86. https://doi.org/10.1016/j.ccr.2008.02.013
  18. Shi TY, Chen XJ, Zhu ML, et al (2013). A pri-miR-218 variant and risk of cervical carcinoma in Chinese women. BMC Cancer, 13, 19. https://doi.org/10.1186/1471-2407-13-19
  19. Tran N, O'Brien CJ, Clark J, et al (2010). Potential role of micro-RNAs in head and neck tumorigenesis. Head Neck, 32, 1099-111. https://doi.org/10.1002/hed.21356
  20. Tie J, Pan Y, Zhao L, et al (2010). MiR-218 inhibits invasion and metastasis of gastric cancer by targeting the Robo1 receptor. PLoS Genet, 6, 1000879. https://doi.org/10.1371/journal.pgen.1000879
  21. Uesugi A, Kozaki K, Tsuruta T, et al (2011). The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res, 71, 5765-78. https://doi.org/10.1158/0008-5472.CAN-11-0368
  22. Volinia S, Calin GA, Liu CG, et al (2006). A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A, 103, 2257-61. https://doi.org/10.1073/pnas.0510565103
  23. Wu DW, Cheng YW, Wang J, et al (2010). Paxillin predicts survival and relapse in non-small cell lung cancer by microRNA-218 targeting. Cancer Res, 70, 10392-401. https://doi.org/10.1158/0008-5472.CAN-10-2341
  24. Wang B, Ma N, Wang YJ (2012). Association Between the hsamir- 27a variant and breast cancer risk: a meta-analysis. Asian Pac J Cancer Prev, 13, 6207-10 https://doi.org/10.7314/APJCP.2012.13.12.6207
  25. Zhou X, Chen X, Hu L, et al (2010). Polymorphisms involved in the miR-218-LAMB3 pathway and susceptibility of cervical cancer, a case-control study in Chinese women. Gynecol Oncol, 117, 287-90. https://doi.org/10.1016/j.ygyno.2010.01.020
  26. Zhang LS, Liang WB, Gao LB, et al (2012). Association Between pri-miR-218 Polymorphism and Risk of Hepatocellular Carcinoma in a Han Chinese Population. DNA Cell Biol, 31, 761-65. https://doi.org/10.1089/dna.2011.1326
  27. Zhang YG, Shi JX, Song CH, et al (2013). Association of mir-499 and mir-149 polymorphisms with cancer risk in the Chinese population: evidence from published studies. Asian Pac J Cancer Prev, 14, 2337-42 https://doi.org/10.7314/APJCP.2013.14.4.2337

피인용 문헌

  1. rs11134527 A>G and Kawasaki disease susceptibility vol.38, pp.3, 2018, https://doi.org/10.1042/BSR20180367