Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Impact of Radiotherapy on Background Parenchymal Enhancement in Breast Magnetic Resonance Imaging

  • Kim, Yun Ju (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Sung Hun (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Choi, Byung Gil (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kang, Bong Joo (Department of Radiology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea) ;
  • Kim, Hyeon Sook (Department of Radiology, St. Paul Hospital, College of Medicine, The Catholic University of Korea) ;
  • Cha, Eun Suk (Department of Radiology, Mokdong Hospital, School of Medicine, Ewha Womans University) ;
  • Song, Byung Joo (Department of General Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea)
  • Published : 2014.04.01
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Abstract

Background: While many studies have shown that hormones can influence background parenchymal enhancement (BPE) in breast magnetic resonance imaging (MRI), only few have directly address the effect of radiotherapy. The purpose of this study was to evaluate the impact of radiotherapy on BPE in breast MRI. Materials and Methods: A retrospective search identified 62 women with unilateral breast cancer who had a breast MRI both before and after radiotherapy following breast-conserving surgery. In our study, we assumed that systemic therapy affected both breasts equivalently. We rated the level of BPE of both breasts using a four-point categorical scale. A change in the level of BPE prior to and after treatment was compared in the diseased and contralateral breasts. Results: All patients received a 4256 to 6480 cGy dose of whole breast radiotherapy over 3-7 weeks. The mean timing of the follow-up study was 6.6 months after completion of radiotherapy. Although the BPE showed a decrease in both breasts after treatment, there was a significant reduction of BPE in the irradiated breast compared with the contralateral breast (1.18 versus 0.98 average reduction in BPE level, p=0.042). Conclusions: Radiotherapy is associated with decrease in BPE with MRI.

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References

  1. Hambly NM, Liberman L, Dershaw DD, Brennan S, Morris EA (2011). Background parenchymal enhancement on baseline screening breast MRI: impact on biopsy rate and short-interval follow-up. Am J Roentgenol, 196, 218-24. https://doi.org/10.2214/AJR.10.4550
  2. King V, Brooks JD, Bernstein JL, et al (2011). Background parenchymal enhancement at breast MR imaging and breast cancer risk. Radiology, 260, 50-60. https://doi.org/10.1148/radiol.11102156
  3. King V, Goldfarb SB, Brooks JD, et al (2012a). Effect of aromatase inhibitors on background parenchymal enhancement and amount of fibroglandular tissue at breast MR imaging. Radiology, 264, 670-8. https://doi.org/10.1148/radiol.12112669
  4. King V, Gu Y, Kaplan JB, et al (2012b). Impact of menopausal status on background parenchymal enhancement and fibroglandular tissue on breast MRI. Eur Radiol, 22, 2641-7. https://doi.org/10.1007/s00330-012-2553-8
  5. King V, Kaplan J, Pike MC, et al (2012c). Impact of tamoxifen on amount of fibroglandular tissue, background parenchymal enhancement, and cysts on breast magnetic resonance imaging. Breast J, 18, 527-34. https://doi.org/10.1111/tbj.12002
  6. Li J, Dershaw DD, Lee CH, Joo S, Morris EA (2010). Breast MRI after conservation therapy: usual findings in routine follow-up examinations. Am J Roentgenol, 195, 799-807. https://doi.org/10.2214/AJR.10.4305
  7. Morris EA (2010). Diagnostic breast MR imaging: current status and future directions. Magn Reson Imaging Clin N Am, 18, 57-74. https://doi.org/10.1016/j.mric.2009.09.005
  8. Mousa NA, Eiada R, Crystal P, Nayot D, Casper RF (2012). The effect of acute aromatase inhibition on breast parenchymal enhancement in magnetic resonance imaging: a prospective pilot clinical trial. Menopause, 19, 420-5. https://doi.org/10.1097/gme.0b013e31823772a8

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