Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
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Effect of chicken egg yolk antibody on canine parvoviral enteritis in pups

개 파보바이러스성 장염에 대한 난황항체의 예방 및 치료 효과

  • Oh, Kyung-Eun (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University) ;
  • Jeoung, Seok-Young (Gangnam Animal Clinics) ;
  • Kim, Bo-Mi (ADBIOTECH Co., Ltd.) ;
  • Jang, Sang-Ho (ADBIOTECH Co., Ltd.) ;
  • Lee, Nam-Hyung (ADBIOTECH Co., Ltd.) ;
  • Cho, Youngjae (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University) ;
  • Kim, Doo (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University) ;
  • Choi, Jung Hoon (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University) ;
  • Hahn, Tae-Wook (College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University)
  • 오경은 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 정석영 (강남동물병원) ;
  • 김보미 ((주)애드바이오텍) ;
  • 장상호 ((주)애드바이오텍) ;
  • 이남형 ((주)애드바이오텍) ;
  • 조영재 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 김두 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 최정훈 (강원대학교 수의과대학 및 동물의학종합연구소) ;
  • 한태욱 (강원대학교 수의과대학 및 동물의학종합연구소)
  • Received : 2013.08.22
  • Accepted : 2014.03.17
  • Published : 2014.06.30
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Abstract

Preventive and therapeutic effects of egg yolk antibody, immunoglobulin Y (IgY), against canine parvovirus (CPV) was evaluated in 25 pups orally challenged with CPV-2a. Oral administration of IgY using powder, paste and coated paste delivery systems was compared. Each type of IgY was administered orally for 17 days from 3 days before challenge. The group of pups administered coated IgY showed mild symptoms such as a moderate decrease in total white blood cell count, no depression, vomiting and diarrhea when compared with other groups. The overall clinical score of the group of pups administered coated IgY was significantly lower than that of the challenge control group. However, mortality did not differ among groups because not all pups received symptomatic treatment. These results implied that oral treatment of coated IgY could improve therapeutic effects against CPV challenge if pups received symptomatic treatment.

Keywords

References

  1. Appel MJG, Cooper BJ, Greisen H, Scott F, Carmichael LE. Canine viral enteritis. I. Status report on corona- and parvo-like viral enteritis. Cornell Vet 1979, 69, 123-133.
  2. Blacklow NR, Greenberg HB. Viral gastroenteritis. N Eng J Med 1991, 325, 252-264. https://doi.org/10.1056/NEJM199107253250406
  3. Cavalli A, Martella V, Desario C, Camero M, Bellacicco AL, De Palo P, Decaro N, Elia G, Buonavoglia C. Evaluation of the antigenic relationships among canine parvovirus type 2 variants. Clin Vaccine Immunol 2008, 15, 534-539. https://doi.org/10.1128/CVI.00444-07
  4. Gassmann M, Thömmes P, Weiser T, Hübscher U. Efficient production of chicken egg yolk antibodies against a conserved mammalian protein. FASEB J 1990, 4, 2528-2532.
  5. Heddle RJ, Rowley D. Dog immunoglobulins. I. Immunochemical characterization of dog serum, parotid saliva, colostrum, milk and small bowel fluid. Immunology 1975, 29, 185-195.
  6. Han S, Zhang X, Zhao J. Production of egg yolk antibody (IgY) against recombinant canine parvovirus VP2 protein. Acta Sci Vet 2012, 40, 1029.
  7. Hoskins JD. Canine viral enteritis. In: Greene CE (ed.). Infectious Diseases of the Dog and Cat. 2nd ed. pp. 40-49, WB Saunders, Philadelphia, 1998.
  8. Janson AK, Smith CIE, Hammarstrom L. Biological properties of yolk immunoglobulins. Adv Exp Med Biol 1995, 371, 685-690. https://doi.org/10.1007/978-1-4615-1941-6_145
  9. Kang BK, Song DS, Lee CS, Jung KI, Park SJ, Kim EM, Park BK. Prevalence and genetic characterization of canine parvoviruses in Korea. Virus Genes 2008, 36, 127-133. https://doi.org/10.1007/s11262-007-0189-6
  10. Kim J, Woo S, Kweon C, Kim J, Huh W. Development of preventive method for enterotoxigenic colibacillosis using egg yolk antibodies. II. Therapeutic effect of egg yolk antibodies against colibacillosis of piglets. Korean J Vet Res 1998, 38, 837-842.
  11. Kovacs-Nolan J, Mine Y. Avian egg antibodies: basic and potential applications. Avian Poult Biol Rev 2004, 15, 25-46. https://doi.org/10.3184/147020604783637462
  12. Kuhlman R, Wiedemann V, Schmidt P, Wanke R, Linckh E, Losch U. Chicken egg antibodies for prophylaxis and therapy of infectious intestinal diseases. I. Immunization and antibody determination. Zentralbl Veterinarmed B1998, 35, 610-616.
  13. Larsson A, Bålöw R, Lindahl TL, Forsberg PO. Chicken antibodies: taking advantage of evolution-a review. Pou Sci 1998, 72, 1807-1812.
  14. Lee H, Kim J, Woo S, Jung B, Cho YS, Tark D, Lim S, Yoo H, Yoon Y, Huh W, Mun Y, Oh J. Control of canine respiratory and diarrheal disease using egg yolk antibodies. I. Induction of antibody in hens immunized with combined antigens of Bordetella bronchiseptica, parvovirus and canine distempervirus. Korea J Vet Res 2004, 44, 65-71.
  15. Lee H, Kim J, Woo S, Jung B, Cho YS, Yoo H, Yoon Y, Huh W, Mun Y, Oh J. Control of canine respiratory and diarrheal disease using egg yolk antibodies. II. Immunoprophylatic effect of egg yolk antibodies in mice and dogs. Korea J Vet Res 2004, 44, 415-420.
  16. Martin V, Najbar W, Gueguen S, Grousson D, Eun HM, Lebreux B, Aubert A. Treatment of canine parvoviral enteritis with interferon-omega in a placebo-controlled challenge trial. Vet Microbiol 2002, 89, 115-127. https://doi.org/10.1016/S0378-1135(02)00173-6
  17. Oh T, Han H. Protective effect of chicken egg yolk antibody in colostrums-deprived neonatal puppies. Korean J Vet Res 1996, 36, 903-913.
  18. Perez R, Bianchi P, Calleros L, Francia L, Hernandez M, Meya L, Panzera Y, Sosa K, Zoller S. Recent spreading of a divergent canine parvovirus type 2a (CPV-2a) strain in a CPV-2c homogenous population. Vet microbiol 2012, 155, 214-219. https://doi.org/10.1016/j.vetmic.2011.09.017
  19. Potgieter LN, Jones JB, Patton CS, Webb-Martin TA. Experimental parvovirus infection in dog. Can J Comp Med 1981, 54, 212-216.
  20. Pratelli A, Cavalli A, Martella V, Tempesta M, Decaro N, Carmichael LE, Buonavoglia C. Canine parvovirus (CPV) vaccination: comparison of neutralizing antibody responses in pups after inoculation with CPV2 or CPV2b modified live virus vaccine. Clin Diagn Lab Immunol 2001, 8, 612-615.
  21. Shimizu M, Fitzsimmons RC, Nakai S. Anti-E.coli immunoglobulin Y isolated from egg yolk of immunized chickens as a potential food ingredient. J Food Sci 1998, 53, 1360-1368.
  22. Swango LJ. Canine viral diseases. In: Ettinger SJ, Felman EC (eds.). Textbook of Veterinary internal medicine: disease of the dog and cat. 4th ed. pp. 398-405, WB Saunders, Philadelphia, 1995.
  23. Van Nguyen S, Umeda K, Yokoyama H, Tohya Y, Kodama Y. Passive protection of dogs against clinical disease due to Canine parvovirus-2 by specific antibody from chicken egg yolk. Can J Vet Res 2006, 70, 62-64.
  24. Wierup M. The control disease in animals: alternatives to the use of antibiotics. Int J Antimicrob Agents 2000, 14, 315-319. https://doi.org/10.1016/S0924-8579(00)00143-6
  25. Yang DK, Kim B, Kim YH, Lee KW, Choi SS, Son SW. Genetic analysis of canine parvovirus vaccine strains in Korea. Korean J Vet Res 2009, 49, 243-248.
  26. Yang DK, Yoon SS, Byun JW, Lee KW, Oh YI, Song JY. Serological survey for Canine parvovirus type 2a(CPV-2a) in the stray dogs in South Korea. J Bacteriol Virol 2010, 40, 77-81. https://doi.org/10.4167/jbv.2010.40.2.77
  27. Yokoyama H, Paralta RC, Diaz R, Sendo S, Ikemori Y, Kodama Y. Passive protective effect of chicken egg yolk immunoglobulins against experimental enterotoxigenic Escherichia coli infection in neonatal piglets. Infect Immun 1992, 60, 998-1007.
  28. Yokoyama H, Paralta RC, Sendo S, Ikemori Y, Kodama Y. Detection of passage and absorption of chicken egg yolk immunoglobulins in the gastrointestinal tract of pigs by use of enzyme-linked immunosorbent assay and fluorescent antibody testing. Am J Vet Res 1993, 54, 867-872.