Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Levels of Serum 25-Hydroxy-Vitamin D in Benign and Malignant Breast Masses

  • Alipour, Sadaf (Department of Surgery, Arash Women's Hospital) ;
  • Hadji, Maryam (Cancer Research Center, Dr. Shariati Hospital, Tehran University of Medical Sciences) ;
  • Hosseini, Ladan (Research Development Center, Arash Women's Hospital) ;
  • Omranipour, Ramesh (Department of Surgery, Cancer Institute, Dr. Shariati Hospital, Tehran University of Medical Sciences) ;
  • Saberi, Azin (Department of Surgery, Arash Women's Hospital) ;
  • Seifollahi, Akram (Department of Pathology, Arash Women's Hospital) ;
  • Bayani, Leila (Department of Radiology, Arash Women's Hospital) ;
  • Shirzad, Nooshin (Endocrinology and Metabolism Research Institute, Dr. Shariati Hospital, Tehran University of Medical Sciences)
  • Published : 2014.01.15
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Abstract

Background: The true association between breast cancer and vitamin D is currently under investigation. We compared serum 25-hydroxy-vitamin D levels in women with benign and malignant breast masses and controls. Materials and Methods: Levels of vitamin D were measured by electrochemiluminescense. Serum levels >35 ng/ml, 25-35 ng/ml, 12.5-25 ng/ml and <12.5 ng/ml were considered as normal, mild, moderate and severe vitamin D deficiency, respectively. Results: Overall, 364 women were included in the control, 172 in the benign and 136 in the malignant groups. The median serum vitamin D level was significantly lower in breast cancers than controls. Levels were also lower in malignant than benign cases and in benign cases than controls although statistically non-significant. Conclusions: Multinomial logistic regression analysis showed that severe vitamin D deficiency causes a three-fold increase in the risk of breast cancer while this was not the case for moderate and mild deficiency.

Keywords

References

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