Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Methylation of O6-Methyl Guanine Methyltransferase Gene Promoter in Meningiomas - Comparison between Tumor Grades I, II, and III

  • Larijani, Leila (Department of Biology, School of Basic Sciences, Science and Research Branch Islamic Azad University (IAU)) ;
  • Madjd, Zahra (Oncopathology Research Centre, Iran University of Medical Sciences) ;
  • Samadikuchaksaraei, Ali (Department of Medical Biotechnology, Faculty of Allied Medicine, Iran University of Medical Sciences) ;
  • Younespour, Shima (Department of Epidemiology and biostatistics, School of Public Health, Tehran University of Medical Sciences) ;
  • Zham, Hanieh (Department of Pathology, Cancer Research Centre) ;
  • Rakhshan, Azadeh (Department of Pathology, Shahid Beheshti University of Medical Science) ;
  • Mohammadi, Foruzan (Department of Pathology, Masih Daneshvari Hospital, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Science) ;
  • Rahbari, Ali (Department of Pathology, Shahid Beheshti University of Medical Science) ;
  • Moradi, Afshin (Department of Pathology, Cancer Research Centre)
  • Published : 2014.01.15
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Abstract

Background: Meningiomas are the second most common primary intracranial tumors after gliomas. Epigenetic biomarkers such as DNA methylation, which is found in many tumors and is thus important in tumorigenesis can help diagnose meningiomas and predict response to adjuvant chemotherapy. We investigated aberrant O6-methyl guanine methyltransferase (MGMT) methylation in meningiomas. Materials and Methods: Sixty-one patients were classified according to the WHO grading, and MGMT promoter methylation status was examined via the methylation-Specific PCR(MSP) method. Results: MGMT promoter methylation was found in 22.2% of grade I, 35% of grade I with atypical features, 36% of grade II, and 42.9% of grade III tumors. Conclusions: There was an increase, albeit not statistically significant, in MGMT methylation with a rise in the tumor grade. Higher methylation levels were also observed in the male gender.

Keywords

References

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