Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Effect of Grape Procyanidins on Tumor Angiogenesis in Liver Cancer Xenograft Models

  • Feng, Li-Li (Department of Oncology, the Affiliated Hospital of Qingdao University) ;
  • Liu, Bing-Xia (Department of Respiration, Yishui Central Hospital of Linyi City) ;
  • Zhong, Jin-Yi (Institute of Nutrition, Medical College of Qingdao University) ;
  • Sun, Li-Bin (Department of Oncology, the Affiliated Hospital of Qingdao University) ;
  • Yu, Hong-Sheng (Department of Oncology, the Affiliated Hospital of Qingdao University)
  • Published : 2014.01.30
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Abstract

Background: In recent years a wide variety of flavonoids or polyphenolic substances have been reported to possess substantial anti-carcinogenic and antimutagenic activities. Grape proanthocyanidins (GPC) are considered as good examples for which there is evidence of potential roles as anti-carcinogenic agents. Methods: A xenograft model was established using H22 cells subcutaneously injected into mice and used to assess different concentrations of grape proanthocyanidins (GPC) and Endostar. Treatments were maintained for 10 days, then levels of vascular endothelial growth factor (VEGF) and microvessel density (MVD) were examined by immunohistochemistry, while VEGF mRNA was determined by real-time PCR in tumor tissue. Results: The expression of MVD and VEGF decreased gradually as the concentration of GPC increased.There was a significant positive correlation between MVD and VEGF. Conclusions: These results suggest that GPC restrains the growth of tumor, possibly by inhibiting tumour angiogenesis.

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References

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