Asian Pacific Journal of Cancer Prevention

  • 제15권2호
  • /
  • Pages.713-716
  • /
  • 2014
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Does HBV Infection Increase Risk of Endometrial Carcinoma?

  • Jiang, Xue-Feng (Department of Obstetrics and Gynecology, the First Affiliated Hospital, Jinan University) ;
  • Tang, Qiong-Lan (Department of Pathology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) ;
  • Zou, Yuan (Department of Ultrasound, Affiliated Hospital of North Sichuan Medical College) ;
  • Xu, Ling (Department of Pediatrics, Guangzhou Women and Childrens Medical Center) ;
  • Zeng, Hua (Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen University) ;
  • Chi, Cong (Department of Obstetrics and Gynecology, the First Affiliated Hospital, Jinan University) ;
  • Jiang, Jing-Ru (Department of Obstetrics and Gynecology, the First Affiliated Hospital, Jinan University) ;
  • Zhang, Bin-Zhong (Department of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University)
  • 발행 : 2014.01.30
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초록

Objective: Connections between chronic inflammation and tumor development and progression are now generally accepted. Recent evidence indicates that hepatitis B is associated with several types of cancer, but whether endometrial carcinoma (EC) is included has not been reported. Methods: We analyzed HBV serum marker status in 398 patients with endometrial cancer, comparing them to 788 control women undergoing health examination. Results: The total prevalence of HBsAg tested positive in cancer group was significantly higher than the control group (12.8% vs 6.0%, P=0.001), while positive HBsAb was significantly lower (41.2% vs 68.5%, P=0.001). Hepatitis B carriers in endometrial cancer group were also more frequent than in the control group (9.3% vs 5.5%, P=0.013). Interestingly, in the endometrial cancer group, 147 cases were HBV serum marker negative, which was also higher than in the control group (36.9% vs 15.6%, P=0.001). Conclusion: There may be a correlation between HBV infection and endometrial carcinoma.

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참고문헌

  1. Becker N, Schnitzler P, Boffetta P, et al (2012). Hepatitis B virus infection and risk of lymphoma: results of a serological analysis within the European case-control study Epilymph. J Cancer Res Clin Oncol, 138, 1993-2001. https://doi.org/10.1007/s00432-012-1279-y
  2. Campagnoli C, Abba C, Ambroggio S et al (2013). Life-style and metformin for the prevention of endometrial pathology in postmenopausal women. Gynecol Endocrinol, 29, 119-24. https://doi.org/10.3109/09513590.2012.706671
  3. Creasman W (2009). Revised FIGO staging for carcinoma of the endometrium. Int J Gynaecol Obstet, 105, 109. https://doi.org/10.1016/j.ijgo.2009.02.010
  4. Hsu CS, Liu CH, Wang CC, et al (2012). Impact of hepatitis B virus infection on metabolic profiles and modifying factors. J Viral Hepat, 19, e48-57. https://doi.org/10.1111/j.1365-2893.2011.01526.x
  5. Iavarone M, Colombo M (2013). HBV infection and hepatocellular carcinoma. Clin Liver Dis, 17, 375-97. https://doi.org/10.1016/j.cld.2013.05.002
  6. Jiang XF, Tang QL, Li HG, et al (2013). Tumor-associated macrophages correlate with progesterone receptor loss in endometrial endometrioid adenocarcinoma. J Obstet Gynaecol Res, 39, 855-63. https://doi.org/10.1111/j.1447-0756.2012.02036.x
  7. Jiang XF, Tang QL, Shen XM, et al (2012). Tumor-associated macrophages, epidermal growth factor receptor correlated with the triple negative phenotype in endometrial endometrioid adenocarcinoma. Pathol Res Pract, 208, 730-5. https://doi.org/10.1016/j.prp.2012.09.011
  8. Jin Y, Gao H, Chen H, et al (2013). Identification and impact of hepatitis B virus DNA and antigens in pancreatic cancer tissues and adjacent non-cancerous tissues. Cancer Lett, 335, 447-54. https://doi.org/10.1016/j.canlet.2013.03.001
  9. King LY, Chung RT (2010). When treating cancer, please don't forget hepatitis B. Oncologist, 15, 826-9. https://doi.org/10.1634/theoncologist.2009-0282
  10. Liang X, Bi S, Yang W, et al (2009). Epidemiological serosurvey of hepatitis B in China--declining HBV prevalence due to hepatitis B vaccination. Vaccine, 27, 6550-7. https://doi.org/10.1016/j.vaccine.2009.08.048
  11. Liu J, Fan D (2007). Hepatitis B in China. Lancet, 369, 1582-3. https://doi.org/10.1016/S0140-6736(07)60723-5
  12. Mantovani A (2005). Cancer: Inflammation by remote control. Nature, 435, 752-3. https://doi.org/10.1038/435752a
  13. Mason A (2006). Role of viral replication in extrahepatic syndromes related to hepatitis B virus infection. Minerva Gastroenterol Dietol, 52, 53-66.
  14. Mason A, Wick M, White H, et al (1993). Hepatitis B virus replication in diverse cell types during chronic hepatitis B virus infection. Hepatology, 18, 781-9. https://doi.org/10.1002/hep.1840180406
  15. Ocana S, Casas ML, Buhigas I, et al (2011). Diagnostic strategy for occult hepatitis B virus infection. World J Gastroenterol, 17, 1553-7. https://doi.org/10.3748/wjg.v17.i12.1553
  16. Park SH, Kim DJ, Lee HY (2009). Insulin resistance is not associated with histologic severity in nondiabetic, noncirrhotic patients with chronic hepatitis B virus infection. Am J Gastroenterol, 104, 1135-39. https://doi.org/10.1038/ajg.2009.6
  17. Siu SS, Cheung TH, Chan PK, et al (2007). Patients with malignant or pre-malignant cervical lesion have increased risk of becoming hepatitis B carrier. J Exp Clin Cancer Res, 26, 77-81.
  18. Sorrell MF, Belongia EA, Costa J, et al (2009). National Institutes of Health Consensus Development Conference statement: Management of hepatitis B. Ann Intern Med, 150, 104-10. https://doi.org/10.7326/0003-4819-150-2-200901200-00100
  19. Terrier B, Cacoub P (2011). Hepatitis B virus, extrahepatic immunologic manifestations and risk of viral reactivation. Rev Med Intern, 32, 622-7. https://doi.org/10.1016/j.revmed.2010.08.013
  20. Uchida T, Kaneita Y, Gotoh K, et al (1997). Hepatitis C virus is frequently coinfected with serum marker-negative hepatitis B virus: probable replication promotion of the former by the latter as demonstrated by in vitro cotransfection. J Med Virol, 52, 399-405. https://doi.org/10.1002/(SICI)1096-9071(199708)52:4<399::AID-JMV10>3.0.CO;2-C
  21. Yeo W, Chan PK, Hui P et al (2003). Hepatitis B virus reactivation in breast cancer patients receiving cytotoxic chemotherapy: A prospective study. J Med Virol, 70, 553-61. https://doi.org/10.1002/jmv.10430
  22. Zur Hausen H (1999). Viruses in Human Cancers. Eur J Cancer, 35, 1174-81. https://doi.org/10.1016/S0959-8049(99)00113-6

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