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Influences of Korean Haw (Crataegus pinnatifida BUNGE) on Lipid Concentration in Hypercholesterolemia

한국산 산사(Crataegus pinnatifida BUNGE)가 고콜레스테롤혈증 지질농도 변화에 미치는 영향

  • Kim, Han-Soo (Department of Food Science & Technology, Pusan National University) ;
  • Kim, Min-A (Department of Food Science & Technology, Pusan National University) ;
  • Jang, Seong-Ho (Department of Bioenviromental Energy, Pusan National University)
  • 김한수 (부산대학교 식품공학과) ;
  • 김민아 (부산대학교 식품공학과) ;
  • 장성호 (부산대학교 바이오환경에너지학과)
  • Received : 2014.01.16
  • Accepted : 2014.02.19
  • Published : 2014.05.30

Abstract

This study was conducted to observe the influences of Crataegus pinnatifida BUNGE extract on lipid concentration in hypercholesterolemic rats (Sprague Dawley, male) fed the experimental diets for 5 weeks. Body weight gain was remarkably lower in the Crataegus pinnatifida BUNGE extract intake group than in the hypercholesterolemic rats. Total cholesterol concentration was remarkably lower in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. Whereas, concentrations of HDL-cholesterol, ratio of HDL-cholesterol concentration to total cholesterol were remarkably higher in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. Atherosclerotic index (AI), cardiac risk factor (CRF) were remarkably lower in the extract of Crataegus pinnatifida BUNGE supplement in hypercholesterolemic rats than in the hypercholesterolemic model. From the above research, Crataegus pinnatifida BUNGE extract was effective on the lipid concentrations in sera of dietary hypercholesterolemic rats.

Keywords

References

  1. Chae, J. K., Kim, G. W., Shin, H. M., 2003, Crataegi Fructus-induced vascular relaxation through release of endotherial nitric oxide, Kor. J. Orient. Physio. & Path., 17(1), 146-150.
  2. Chon, J. W., Park, J. K., Lee, M. A., Jeong, M. R., Han, J. H., Park, Y. K., 2009, Fermented Crataegi fructus vinegar improves lipid metabolism in rats fed high fat diet, J. Kor. Soc. Food Sci. Nutr., 38(8), 1024-1031. https://doi.org/10.3746/jkfn.2009.38.8.1024
  3. Chung, S. T., Chung, D. C., Lee, B. K., 1997, Relative risk of hypertension for obesity, hypercholesterolemia and hypertriglyceridemia, Exercise Sci., 6(1), 45-57.
  4. Grundy, S. M., 1998, Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome, Am. J. Cardio., 81(4), 18-25.
  5. Han, K. Y., Jeong, S. H., Yang, J. H., Lee, H. S., 1992, Factors affecting serum lipid levels by analysis of adult health examination, J. Kor. Acad. Fam. Med., 13(12), 943-950.
  6. Heo, H. J., Nam, S. Y., Lee, S. K., Chung, S. J., Yoon, J. H., 2012, The relationship between high energy/low nutrient food consumption and obesity among Korean children and adolescents, Kor. J. Community Nutr., 17(2), 226-242. https://doi.org/10.5720/kjcn.2012.17.2.226
  7. Hong, S. S., Hwang, J. S., Lee, S. A., Han, X. A., Ro, J. S., Lee, K. S., 2002, Inhibitors of monoamine oxidase activity from the fruits of Crataegus pinnatifida Bunge, Kor. J. Pharmacogn., 33(4), 285-290.
  8. Jun, D. W., 2013, The role of diet in non-alcoholic fatty liver disease, Kor. J. Gastroenterol., 61(5), 243-251. https://doi.org/10.4166/kjg.2013.61.5.243
  9. Kang, S. A., Jang, K. H., Hong, K. H., Choi, W. A., Jung, K. H., Lee, I. Y., 2002, Effects of dietary ${\beta}$ -glucan on adiposity and serum lipids levels in obese rats induced by high fat diet, J. Kor. Soc. Food Sci. Nutr., 31(6), 1052-1057. https://doi.org/10.3746/jkfn.2002.31.6.1052
  10. Kim, J. S., Lee, G. D., Kwon, J. H., Yoon, H. S., 1993, Identification of phenolic antioxidative components in Crataegus pinnatifida Bunge, J. Kor. Agric. Chem. Soc., 36(3), 154-157.
  11. Kwok, C. Y., Wong, C. N. Y., Yau, M. Y. C., Yu, P. H. F., Au, A. L. S., Poon, C. C. W., Seto, S. W., Lam, T. Y., Kwan, Y. W., Chan, S. W., 2010, Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats, J. Functional Foods, 2(3), 179-186. https://doi.org/10.1016/j.jff.2010.04.006
  12. Kwon, J. Y., Ann, I. S., Park, K. Y., Cheigh, H. S., Song, Y. O., 2005, The beneficial effects of pectin on obesity in vitro and in vivo, J. Kor. Soc. Food Sci. Nutr., 34(1), 13-20. https://doi.org/10.3746/jkfn.2005.34.1.013
  13. Kwon, S. H., Kim, J. B., 2010, Effects of Crataegii Fructus on the diet-induced hyperlipidemia in rats, Kor. J. Orient. Physio. & Path., 24(1), 67-73.
  14. Lee, H. J., Choi, M. S., 1999, Measurement of inhibitory activities on 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA:cholesterol acyltransferase by various plant extracts in vitro, J. Kor. Soc. Food Sci. Nutr., 28(4), 958-962.
  15. Lim, J. D., Yu, C. Y., Kim, M. J., Yun, S. J., Lee, S. J., Kim, N. Y., Chung, I. M., 2004, Comparison of SOD activity and phenolic compound contents in various Korean medicinal plants, Kor. J. Medicinal Crop. Sci., 12(3), 191-202.
  16. Liu, T., Cao, Y., Zhao, M., 2010, Extraction optimization, purification and antioxidant activity of procyanidins from hawthorn (C. pinnatifida Bge. var. major) fruits, Food Chem., 119(4), 1656-1662. https://doi.org/10.1016/j.foodchem.2009.09.001
  17. Park, S. H., Kim, Y. H., Chon, J. W., Song, Y. J., Han, J. H., 2005, Study of Crataegi Fructus for medicinal foods applications-functional evaluation of fermented liquid on the lipid profile improvement high fat diet, Kor. J. Orient. Physio., 19(5), 1272-1280.
  18. Park, S. J., Han, K. S., Yoo, S. M., 2012, Nutritional characteristics and screening of biological activity of Crataegi fructus, Kor. J. Food & Nutr., 25(3), 413-418. https://doi.org/10.9799/ksfan.2012.25.3.413
  19. Ryu, H. Y., Ahn, S. M., Kim, J. S., Jung, I. C., Sohn, H. Y., 2010, Antimicrobial activity of fruit of Crataegus pinnatifida Bunge against multidrug resistant pathogenic Pseudomonas aeruginosa and Candida sp., Kor. J. Microbiol. Biotechnol., 38(1), 77-83.
  20. Shin, J. H., Jo, M. J., Park, S. M., Park, S. J., Kim, S. C., 2010, Hepatoprotective activity of Crataegii fructus water extract against cadmium-induced toxicity in rats, Kor. J. Orient. Physio. & Path., 24(2), 249-257.
  21. Won, S. H., Kwon, K. R., Rhim, T. J., Kim, D. H., 2008, The effect of Crataegi Fructus pharmacopuncture on adipocyte metabolism, J. Pharmaco., 11(2), 63-73.