DOI QR코드

DOI QR Code

Improvement Effect of Hyperlipidemia by Wild Haw (Crataegus pinnatifida BUNGE)

자생 산사(Crataegus pinnatifida BUNGE)의 고지혈증 개선 효과

  • Kim, Han-Soo (Department of Food Science & Technology, Pusan National University) ;
  • Kim, Min-A (Department of Food Science & Technology, Pusan National University) ;
  • Jang, Seong-Ho (Department of Bioenviromental Energy, Pusan National University)
  • 김한수 (부산대학교 식품공학과) ;
  • 김민아 (부산대학교 식품공학과) ;
  • 장성호 (부산대학교 바이오환경에너지학과)
  • Received : 2014.01.16
  • Accepted : 2014.02.19
  • Published : 2014.05.30

Abstract

The objective of this study was to investigate the effects of the Crataegus pinnatifida BUNGE extract supplementation of non esterified fatty acid (NEFA), concentrations of serum protein and electrolyte in sera on the hyperlipidemic rats. Concentrations of NEFA and globulin were remarkably lower in the Crataegus pinnatifida BUNGE extract group (HW group) than in the hyperlipidemic group (HD group), but no difference between control group (CO group) and extract of Crataegus pinnatifida BUNGE supplement in control group (NW group). However, concentrations of electrolyte K and A/G were higher in the HW group than HD group. Concentrations of total protein, albumin, electrolyte of total Ca, Pi, Na and Cl were no difference between HW group than HD group. The results indicate that Crataegus pinnatifida BUNGE extract was in the improvement of hyperlipidemic rats.

Keywords

References

  1. Bae, M. H., Kim, H. H., 2003, Mechanism of Crataegi fructus extract induced endothelium-dependent vasorelaxation in rabbit carotid artery, Kor. J. Herbology, 18(3), 169-180.
  2. Cho, Y. S., Jang, E. M., Jang, S. M., Chun, M. S., Shon, M. S., Kim, M. J., Lee, M. K., 2007, Effect of grape seed water extract on lipid metabolism and erythrocyte antioxidant defense system in high fat diet-induced obese C57BL/6 mice, J. Kor. Soc. Food Sci. Nutr., 36(12), 1537-1543. https://doi.org/10.3746/jkfn.2007.36.12.1537
  3. Choi, H. J., Kim, E. J., Han, M. J., Baek, N. I., Kim, D. H., Jung, H. G., Kim, N. J., 2007, Hepatoprotective effect of fermented Artemisia princeps PAMPANINI by lactic acid bacteria, Kor. J. Pharmacogn., 38(3), 245-253.
  4. Chon, J. W., Park, J. K., Lee, M. A., Jeong, M. R., Han, J. H., Park, Y. K., 2009, Fermented Crataegi fructus vinegar improves lipid metabolism in rats fed high fat diet, J. Kor. Soc. Food Sci. Nutr., 38(8), 1024-1031. https://doi.org/10.3746/jkfn.2009.38.8.1024
  5. Chon, J. W., Park, S. J., Han, J. H., Park, S. H., 2005, Study of Crataegi fructus for medicinal foods applications-nutrition composition and scheme for foods-, Kor. J. Oriental Physiology & Pathology, 19(5), 1220-1224.
  6. Hong, S. I., Park, H. J., Kwak, S. J., Park, S. H., Yu, H. J., Won, D. J., Prak, J. S., Lee, D. J., Ahn, S. H., Koo, J. S., 1996, Comparison of atherosclerotic heart disease risks between vegetarian and non-vegetarian, Kor. J. Medicine, 51(1), 45-52.
  7. Hwang, K. H., Jung, L. H., Cho, N. C., Yoo, Y. K., Park, P. S., Noh, Y. H., Seo, H. S., Noh, I. O., 2003, The effect of concentrated onion juice in a body compositon, serum electrolytes and lipids levels on hyperlipidemia, Kor. J. Food & Nutr., 16(1), 36-45.
  8. Kim, H. S., 2005, Effects of Prunus persica Batsch var. davidiana Max. extract on the free fatty acid, creatine, phosphokinase and LCAT activities in hypercholesterolemic rats, Kor. J. Food & Nutr., 18(3), 265-271.
  9. Kim, K. A., 2009, Understanding and application of liver function tests, Kor. J. Medicine, 76(2), 163-168.
  10. Kim, M. W., Kim, E. J., 1969, The changes of serum protein and lipoproteins in Korean diabetic patients and alloxan-diabetic rabbits, Kor. J. Internal Medicine 12(9), 5-21.
  11. Kim, Y. J., 2008, Interpretation of liver function tests, Kor. J. Gastroenterology, 51, 219-224.
  12. Kwon, M, A., Kim, G. S., Hong, J. K., Jo, H. S., Kim, J. K., Yang, M. K., Lee, B. D., 2003, The effects of 0.45% and 0.9% saline solutions on serum sodium concentrations in chronic renal failure patients, Kor. J. Anesthesiology, 44(4), 462-468.
  13. Lee, S. K., Lee, S. S., Baek, J. W., Lee, S. J., Kim, K. H., 2003, Effect of Crataegii fructus on serum lipid in high cholesterol diet induced hyperlipide rats, Kor. J. Oriental Preventive medical Society, 7(2), 13-22.
  14. Liu, R. H., 2003, Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals, Am. J. Clin. Nutr. 78(3), 517-520.
  15. Liu, T., Cao, Y., Zhao, M., 2010, Extraction optimization, purification and antioxidant activity of procyanidins from hawthorn (C. pinnatifida Bge. var. major) fruits, Food Chemistry, 119(4), 1656-1662. https://doi.org/10.1016/j.foodchem.2009.09.001
  16. Park, S. J., Han, K. S., Yoo, S. M., 2012, Nutritional characteristics and screening of biological activity of Crataegi fructus, Kor. J. Food & Nutr., 25(3), 413-418. https://doi.org/10.9799/ksfan.2012.25.3.413
  17. Ryu, B. H., Koo, K. S., Baek, U. H., Bang, H. S., Hong, Y. J., Park, S. W., Lee, H. M., 2007, The effect of eight-weeks exercise therapy and diet therapy on male middle school students obesity and physical fitness, Kor. J. Growth and Development, 15(2), 87-93.
  18. Ryu, H. Y., Ahn, S. M., Kim, J. S., Jung, I. C., Sohn, H. Y., 2010, Antimicrobial activity of fruit of Crataegus pinnatifida Bunge against multidrug resistant pathogenic Pseudomonas aeruginosa and Candida sp, Kor. J. Microbiol. Biotechnol., 38(1), 77-83.
  19. Tadic, V. M., Dobric, S., Markovic, G. M., Dordevic, S. M., Arsic, I. A., Menkovic, N. R., Stevic, T., 2008. Anti-inflammatory, gastroprotective, free radical scavenging and antimicrobial activities of hawthorn berries ethanol extract, J. Agric. Food Chem., 56, 7700-7709. https://doi.org/10.1021/jf801668c
  20. Van Gaal, L. F., Mertens, I. L., Christophe, E., 2006, Mechanisms linking obesity with cardiovascular disease, Nature, 444, 875-880. https://doi.org/10.1038/nature05487
  21. Wang, S. B., Ahn, E. M., Jung, J. W., 2009, The fruits of Crataegus pinnatifida Bunge ameliorates learning and memory impairments induced by scopolamine, Kor. J. Herbology, 24(4), 165-171.