Toxicological Research

  • 제30권1호
  • /
  • Pages.55-63
  • /
  • 2014
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Studies on the Toxicity and Distribution of Indium Compounds According to Particle Size in Sprague-Dawley Rats

  • Lim, Cheol Hong (Toxicity Research Team, Occupational Safety and Health Research Institute, KOSHA) ;
  • Han, Jeong-Hee (Toxicity Research Team, Occupational Safety and Health Research Institute, KOSHA) ;
  • Cho, Hae-Won (Toxicity Research Team, Occupational Safety and Health Research Institute, KOSHA) ;
  • Kang, Mingu (Toxicity Research Team, Occupational Safety and Health Research Institute, KOSHA)
  • 투고 : 2014.03.18
  • 심사 : 2014.03.30
  • 발행 : 2014.03.31
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The use of indium compounds, especially those of small size, for the production of semiconductors, liquid-crystal panels, etc., has increased recently. However, the role of particle size or the chemical composition of indium compounds in their toxicity and distribution in the body has not been sufficiently investigated. Therefore, the aim of this study was to examine the effects of particle size and the chemical composition of indium compounds on their toxicity and distribution. Methods: Male Sprague-Dawley rats were exposed to two different-sized indium oxides (average particle sizes under 4,000 nm [IO_4000] and 100 nm [IO_100]) and one nano-sized indium-tin oxide (ITO; average particle size less than 50 nm) by inhalation for 6 hr daily, 5 days per week, for 4 weeks at approximately $1mg/m^3$ of indium by mass concentration. Results: We observed differences in lung weights and histopathological findings, differential cell counts, and cell damage indicators in the bronchoalveolar lavage fluid between the normal control group and IO- or ITO-exposed groups. However, only ITO affected respiratory functions in exposed rats. Overall, the toxicity of ITO was much higher than that of IOs; the toxicity of IO_4000 was higher than that of IO_100. A 4-week recovery period was not sufficient to alleviate the toxic effects of IO and ITO exposure. Inhaled indium was mainly deposited in the lungs. ITO in the lungs was removed more slowly than IOs; IO_4000 was removed faster than IO_100. IOs were not distributed to other organs (i.e., the brain, liver, and spleen), whereas ITO was. Concentrations of indium in the blood and organ tissues were higher at 4 weeks after exposure. Conclusions: The effect of particle size on the toxicity of indium compounds was not clear, whereas chemical composition clearly affected toxicity; ITO showed much higher toxicity than that of IO.

키워드

참고문헌

  1. Woon, Y.R., Kim, E., Kim, H.Y., Lee, M. and Choi, S.R. (2012) Pulmonary disorder with indium compounds. Occupational Safety and Health Research Institute study report 2012-1288, Incheon, pp. 1-3.
  2. Leach, L.J., Scott, J.K., Armstrong, R.D., Steadman, L.T. and Maynard, E.A. (1961) The inhalation toxicity of indium sesquioxide in the rat. Atomic Energy Project Report No. UR-590, Rochester, NY: University of Rochester. No. UR590.
  3. American Conference of Governmental Industrial Hygienists (ACGIH). (1986) Documentation of the threshold limit values and biological exposure indices (Fifth edition), Cincinnati, pp. 101.
  4. Ministry of Employment and Labor (MOEL). (2013) The notification No. 2013-38 for exposure standard on chemical substances and physical properties issued on August 14, MOEL, Korea, No. 2013-38.
  5. Ministry of Health Labour and Welfare (MHLW). (2004) The notification No. 0713001 for protecting workers exposure to indium-tin oxide and its related indium compounds issued on July 13, MHLW, Japan, No. 0713001.
  6. Ministry of Health Labour and Welfare (MHLW). (2010) The notification No. 1222-3 for the technical guideline for preventing health impairment of workers engaged in the indiumtin oxides handling processes released on December 22, MHLW, Japan, No. 1222-3.
  7. Ministry of Health Labour and Welfare (MHLW). (2010) Indium and indium compounds. Initial risk assessment report, MHLW, Japan, No. 42.
  8. Ministry of Health Labour and Welfare (MHLW). (2011) Indium and indium compounds. Initial risk assessment report, MHLW, Japan, No. 42.
  9. Ministry of Health Labour and Welfare (MHLW). (2014) Specific chemical substances ordinance on prevention. MHLW, Japan.
  10. Wittmaack, K. (2007) In search of the relevant parameter for quantifying lung inflammatory response to nanoparticle exposure: particle number, surface area, or what? Environ. Health Perspect., 115, 187-194.
  11. National Institute for Occupational Safety and Health (NIOSH). (2011) Occupational Exposure to Titanium Dioxide. Current Intelligence Bulletin 63, Atlanta.
  12. Lee, N., Kwon, J.H. and Yi, G.Y. (2012) Research on exposure level to nanoparticles and work characteristics handling with nanomaterials. Occupational Safety and Health Research Institute study report 2012-1285, Incheon, pp. 29-33.
  13. Homma, T., Ueno, T., Sekizawa, K., Tanaka, A. and Hirata, M. (2003) Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide. J. Occup. Health, 45, 137-139. https://doi.org/10.1539/joh.45.137
  14. Homma, S., Miyamoto, A., Sakamoto, S., Kishi, K., Motoi, N. and Yoshimura, K. (2005) Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide. Eur. Respir. J., 25, 200-204. https://doi.org/10.1183/09031936.04.10012704
  15. Taguchi, O. and Chonan, T. (2006) [Three cases of indium lung]. Nihon Kokyuki Gakkai Zasshi, 44, 532-536.
  16. Cummings, K.J., Nakano, M., Omae, K., Takeuchi, K., Chonan, T., Xiao, Y.L., Harley, R.A., Roggli, V.L., Hebisawa, A., Tallaksen, R.J., Trapnell, B.C., Day, G.A., Saito, R., Stanton, M.L., Suarthana, E. and Kreiss, K. (2012) Indium lung disease. Chest, 141, 1512-1521. https://doi.org/10.1378/chest.11-1880
  17. Cummings, K.J., Donat, W.E., Ettensohn, D.B., Roggli, V.L., Ingram, P. and Kreiss, K. (2010) Pulmonary alveolar proteinosis in workers at an indium processing facility. Am. J. Respir. Crit. Care Med., 181, 458-464. https://doi.org/10.1164/rccm.200907-1022CR
  18. Xiao, Y.L., Cai, H.R., Wang, Y.H., Meng, F.Q. and Zhang, D.P. (2010) Pulmonary alveolar proteinosis in an indium-processing worker. Chin. Med. J., 123, 1347-1350.
  19. Maynard, A.D., Warheit, D.B. and Philbert, M.A. (2011) The new toxicology of sophisticated materials: Nanotoxicology and beyond. Toxicol. Sci., 120, S109-S129. https://doi.org/10.1093/toxsci/kfq372
  20. Asakura, K., Satoh, H., Chiba, M., Okamoto, M., Serizawa, K., Nakano, M. and Omae, K. (2008) Oral toxicity of indium in rats: single and 28-day repeated administration studies. J. Occup. Health, 50, 471-479. https://doi.org/10.1539/joh.L8070
  21. Tanaka, A., Hirata, M., Homma, T. and Kiyohara Y. (2010) Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters. J. Occup. Health, 52, 14-22. https://doi.org/10.1539/joh.L9097
  22. Nagano, K., Gotoh, K., Kasai, T., Aiso, S, Nishizawa, T., Ohnishi, M., Ikawa, N., Eitaki, Y., Yamada, K., Arito, H. and Fukushima, S. (2011) Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats. J. Occup. Health, 53, 51-63. https://doi.org/10.1539/joh.L10128
  23. Nagano, K., Nishizawa, T., Eitaki, Y., Ohnishi, M., Noguchi, T., Arito, H. and Fukushima, S. (2011) Pulmonary toxicity in mice by 2- and 13-week inhalation exposures to indium-tin oxide and indium oxide aerosols. J. Occup. Health, 53, 234-239. https://doi.org/10.1539/joh.10-0053-BR
  24. Nagano, K., Nishizawa, T., Umeda, Y., Kasai, T., Noguchi, T., Gotoh, K., Ikawa, N., Eitaki, Y., Kawasumi, Y., Yamauchi, T., Arito, H. and Fukushima, S. (2011) Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice. J. Occup. Health, 53, 175-187. https://doi.org/10.1539/joh.10-0057-OA
  25. Yi, G.Y., Lee, N. and Shin, J. (2011) Research on exposure and management of insoluble indium compound I. Occupational Safety and Health Research Institute study report 2011-1409, Incheon, pp. 6-18.
  26. United Nations. (2013) Globally harmonized system of classification and labeling of chemicals (GHS) (Fifth revised edition), New York and Geneva, pp. 10.
  27. Japan Society for Occupational Health (JSOH). (2007) Documentation of OEL and BEI for indium and its compounds. Sangyo Eiseigaku Zasshi, 49, 196-202.

피인용 문헌

  1. Pulmonary toxicity of indium-tin oxide production facility particles in rats vol.36, pp.4, 2015, https://doi.org/10.1002/jat.3253
  2. Twenty-eight-day repeated inhalation toxicity study of nano-sized lanthanum oxide in male sprague-dawley rats vol.32, pp.4, 2017, https://doi.org/10.1002/tox.22319
  3. Indium oxide (In2O3) nanoparticles induce progressive lung injury distinct from lung injuries by copper oxide (CuO) and nickel oxide (NiO) nanoparticles vol.90, pp.4, 2016, https://doi.org/10.1007/s00204-015-1493-x
  4. Comparing plasma, serum and whole blood indium concentrations from workers at an indium-tin oxide (ITO) production facility pp.1470-7926, 2016, https://doi.org/10.1136/oemed-2016-103685
  5. Facile synthesis of near-infrared CuInS2/ZnS quantum dots and glycol-chitosan coating for in vivo imaging vol.19, pp.7, 2017, https://doi.org/10.1007/s11051-017-3944-1
  6. Risk assessment of zinc oxide, a cosmetic ingredient used as a UV filter of sunscreens vol.20, pp.3, 2017, https://doi.org/10.1080/10937404.2017.1290516
  7. Application of the ICRP respiratory tract model to estimate pulmonary retention of industrially sampled indium-containing dusts vol.29, pp.4, 2017, https://doi.org/10.1080/08958378.2017.1333548
  8. Particle-induced Pulmonary Alveolar Proteinosis and Subsequent Inflammation and Fibrosis: A Toxicologic and Pathologic Review vol.45, pp.3, 2017, https://doi.org/10.1177/0192623316688959