Journal of Korean geriatric psychiatry (노인정신의학)

Korean Association for Geriatric Psychiatry (대한노인정신의학회)
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Prevalence and Associated Factors of Depression in Mild Cognitive Impairment

경도인지장애에서 우울증 유병률과 관련요인

  • Lee, Jun Ho (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Choe, Young Min (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Byun, Min Soo (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Choi, Hyo Jung (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Baek, Hyewon (Department of Neuropsychiatry, Seoul National University Hospital) ;
  • Sohn, Bo Kyung (Department of Psychiatry, Seoul National University College of Medicine) ;
  • Lee, Dong Young (Department of Neuropsychiatry, Seoul National University Hospital)
  • 이준호 (서울대학교병원 정신건강의학과) ;
  • 최영민 (서울대학교병원 정신건강의학과) ;
  • 변민수 (서울대학교병원 정신건강의학과) ;
  • 최효정 (서울대학교병원 정신건강의학과) ;
  • 백혜원 (서울대학교병원 정신건강의학과) ;
  • 손보경 (서울대학교 의과대학 정신과학교실) ;
  • 이동영 (서울대학교병원 정신건강의학과)
  • Received : 2014.08.07
  • Accepted : 2014.09.02
  • Published : 2014.10.30

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Abstract

Objective : The aims of this study were to investigate the prevalence of co-morbid depression and related factors of depression in mild cognitive impairment (MCI) patients. Methods : Nine hundred and six MCI individuals were included in this study. Depression was defined as major and minor depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Depression-related demographic and clinical factors were also explored through multivariate logistic regression analysis. Results : In MCI patients, the prevalence of depression as defined according to the DSM-IV diagnostic criteria was 1.8% for major depressive disorder, 11.4% for minor depressive disorder, and overall 13.2% for both. Multivariate logistic regression showed that increased prevalence of overall depression was associated with female gender and non-amnestic subtype of MCI. Conclusion : Our findings based on a large number of MCI subjects who visited memory clinic indicated that more than ten percent of MCI patients have comorbid depression. In addition, female and non-amnestic subtype of MCI patients seems to be more vulnerable to depression.

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Acknowledgement

본 연구는 미래창조과학부의 연구비 지원에 의해 이루어짐(NRF-2014M3C7A1046042).