한국발생생물학회지:발생과생식 (Development and Reproduction)

  • 제18권1호
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  • Pages.65-71
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  • 2014
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  • 2465-9525(pISSN)
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  • 2465-9541(eISSN)
한국발생생물학회 (The Korean Society of Developmental Biology)
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Polo-Like Kinases (Plks), a Key Regulator of Cell Cycle and New Potential Target for Cancer Therapy

  • Lee, Su-Yeon (Department of Biomedical Science, College of Life Science, CHA University) ;
  • Jang, Chuljoon (Department of Biomedical Science, College of Life Science, CHA University) ;
  • Lee, Kyung-Ah (Department of Biomedical Science, College of Life Science, CHA University)
  • 투고 : 2014.01.20
  • 심사 : 2014.02.15
  • 발행 : 2014.03.31
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초록

Cell cycle process is regulated by a number of protein kinases and among them, serine/threonine kinases carry phosphate group from ATP to substrates. The most important three kinase families are Cyclin-dependent kinase (Cdk), Polo-like kinase (Plk), and Aurora kinase. Polo-like kinase family consists of 5 members (Plk1-Plk5) and they are involved in multiple functions in eukaryotic cell division. It regulates a variety of aspects such as, centrosome maturation, checkpoint recovery, spindle assembly, cytokinesis, apoptosis and many other features. Recently, it has been reported that Plks are related to tumor development and over-expressed in many kinds of tumor cells. When injected the anti-Plk antibody into human cells, the cells show aneuploidy, and if inhibit Plks, most of the mitotic cell division does not proceed properly. For that reasons, many inhibitors of Plk have been recently emerged as new target for remedy of the cancer therapeutic research. In this paper, we reviewed briefly the characteristics of Plk families and how Plks work in regulating cell cycles and cancer formation, and the possibilities of Plks as target for cancer therapy.

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참고문헌

  1. Ando K, Ozaki T, Yamamoto H, Furuya K, Hosoda M, Hayashi S, Fukuzawa M, Nakagawara A (2004) Pololike kinase 1 (Plk1) inhibits p53 function by physical interaction and phosphorylation. J Biol Chem 279: 25549-25561. https://doi.org/10.1074/jbc.M314182200
  2. Brinkley BR (2001) Managing the centrosome numbers game: from chaos to stability in cancer cell division. Trends Cell Biol 11:18-21. https://doi.org/10.1016/S0962-8924(00)01872-9
  3. Burns TF, Fei P, Scata KA, Dicker DT, El-Deiry WS (2003) Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol 23:5556-5571. https://doi.org/10.1128/MCB.23.16.5556-5571.2003
  4. Casenghi M, Meraldi P, Weinhart U, Duncan PI, Korner R, Nigg EA (2003) Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation. Dev Cell 5:113-125. https://doi.org/10.1016/S1534-5807(03)00193-X
  5. Cizmecioglu O, Krause A, Bahtz R, Ehret L, Malek N, Hoffmann I (2012) Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4). J Cell Sci 125:981-992. https://doi.org/10.1242/jcs.095075
  6. Cizmecioglu O, Warnke S, Arnold M, Duensing S, Hoffmann I (2008) Plk2 regulated centriole duplication is dependent on its localization to the centrioles and a functional polo-box domain. Cell Cycle 7:3548-3555. https://doi.org/10.4161/cc.7.22.7071
  7. Conn CW, Hennigan RF, Dai W, Sanchez Y, Stambrook PJ (2000) Incomplete cytokinesis and induction of apoptosis by overexpression of the mammalian polo-like kinase, Plk3. Cancer Res 60:6826-6831.
  8. Dai W (2005) Polo-like kinases, an introduction. Oncogene 24:214-216. https://doi.org/10.1038/sj.onc.1208270
  9. de Carcer G, Manning G, Malumbres M (2011a) From Plk1 to Plk5: functional evolution of polo-like kinases. Cell Cycle 10:2255-2262. https://doi.org/10.4161/cc.10.14.16494
  10. de Carcer G, Escobar B, Higuero AM, Garcia L, Anson A, Perez G, Mollejo M, Manning G, Melendez B, Abad- Rodriguez J, Malumbres M (2011b) Plk5, a polo box domain-only protein with specific roles in neuron differentiation and glioblastoma suppression. Mol Cell Biol 31:1225-1239. https://doi.org/10.1128/MCB.00607-10
  11. Degenhardt Y, Lampkin T (2010) Targeting Polo-like kinase in cancer therapy. Clin Cancer Res 16:384-389. https://doi.org/10.1158/1078-0432.CCR-09-1380
  12. Descombes P, Nigg EA (1998) The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J 17:1328-1335. https://doi.org/10.1093/emboj/17.5.1328
  13. Glover DM, Hagan IM, Tavares AA (1998) Polo-like kinases: a team that plays throughout mitosis. Genes Dev 12: 3777-3787. https://doi.org/10.1101/gad.12.24.3777
  14. Haren L, Stearns T, Luders J (2009) Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS One 4:e5976. https://doi.org/10.1371/journal.pone.0005976
  15. Iida M, Matsuda M, Komatani H (2008) Plk3 phosphorylates topoisomerase II alpha at Thr(1342), a site that is not recognized by Plk1. Biochem J 411:27-32. https://doi.org/10.1042/BJ20071394
  16. Jang MS, Lee SJ, Kim CJ, Lee CW, Kim E (2011) Phosphorylation by polo-like kinase 1 induces the tumor-suppressing activity of FADD. Oncogene 30: 471-481. https://doi.org/10.1038/onc.2010.423
  17. Jang YJ, Ji JH, Choi YC, Ryu CJ, Ko SY (2007) Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. J Biol Chem 282:2473-2482. https://doi.org/10.1074/jbc.M605480200
  18. Karsenti E, Kobayashi S, Mitchison T, Kirschner M (1984) Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes. J Cell Biol 98:1763-1776. https://doi.org/10.1083/jcb.98.5.1763
  19. Kleylein-Sohn J, Westendorf J, Le Clech M, Habedanck R, Stierhof YD, Nigg EA (2007) Plk4-induced centriole biogenesis in human cells. Dev Cell 13:190-202. https://doi.org/10.1016/j.devcel.2007.07.002
  20. Knecht R, Elez R, Oechler M, Solbach C, von Ilberg C, Strebhardt K (1999) Prognostic significance of pololike kinase (PLK) expression in squamous cell carcinomas of the head and neck. Cancer Res 59:2794-2797.
  21. Kops GJ, Weaver BA, Cleveland DW (2005) On the road to cancer: aneuploidy and the mitotic checkpoint. Nat Rev Cancer 5:773-785. https://doi.org/10.1038/nrc1714
  22. Lajoie-Mazenc I, Tollon Y, Detraves C, Julian M, Moisand A, Gueth-Hallonet C, Debec A, Salles-Passador I, Puget A, Mazarguil H, et al. (1994) Recruitment of antigenic gamma-tubulin during mitosis in animal cells: presence of gamma-tubulin in the mitotic spindle. J Cell Sci 107 (Pt 10):2825-2837.
  23. Lane HA, Nigg EA (1996) Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes. J Cell Biol 135:1701-1713. https://doi.org/10.1083/jcb.135.6.1701
  24. Liu X, Erikson RL (2003) Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells. Proc Natl Acad Sci U S A 100:5789-5794. https://doi.org/10.1073/pnas.1031523100
  25. Lopez-Sanchez I, Sanz-Garcia M, Lazo PA (2009) Plk3 interacts with and specifically phosphorylates VRK1 in Ser342, a downstream target in a pathway that induces Golgi fragmentation. Mol Cell Biol 29:1189-1201. https://doi.org/10.1128/MCB.01341-08
  26. Ma S, Charron J, Erikson RL (2003) Role of Plk2 (Snk) in mouse development and cell proliferation. Mol Cell Biol 23:6936-6943. https://doi.org/10.1128/MCB.23.19.6936-6943.2003
  27. Macmillan JC, Hudson JW, Bull S, Dennis JW, Swallow CJ (2001) Comparative expression of the mitotic regulators SAK and PLK in colorectal cancer. Ann Surg Oncol 8:729-740. https://doi.org/10.1007/s10434-001-0729-6
  28. Maniotis A, Schliwa M (1991) Microsurgical removal of centrosomes blocks cell reproduction and centriole generation in BSC-1 cells. Cell 67:495-504. https://doi.org/10.1016/0092-8674(91)90524-3
  29. McInnes C, Wyatt MD (2011) PLK1 as an oncology target: current status and future potential. Drug Discov Today 16:619-625. https://doi.org/10.1016/j.drudis.2011.05.002
  30. Ohkura H, Hagan IM, Glover DM (1995) The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells. Genes Dev 9:1059-1073. https://doi.org/10.1101/gad.9.9.1059
  31. Peter ME, Scaffidi C, Medema JP, Kischkel F, Krammer PH (1999) The death receptors. Results Probl Cell Differ 23:25-63. https://doi.org/10.1007/978-3-540-69184-6_3
  32. Pihan GA, Purohit A, Wallace J, Malhotra R, Liotta L, Doxsey SJ (2001) Centrosome defects can account for cellular and genetic changes that characterize prostate cancer progression. Cancer Res 61:2212-2219.
  33. Qian YW, Erikson E, Li C, Maller JL (1998) Activated polo-like kinase Plx1 is required at multiple points during mitosis in Xenopus laevis. Mol Cell Biol 18: 4262-4271. https://doi.org/10.1128/MCB.18.7.4262
  34. Shimada K, Matsuyoshi S, Nakamura M, Ishida E, Konishi N (2005) Phosphorylation status of Fas-associated death domain-containing protein (FADD) is associated with prostate cancer progression. J Pathol 206:423-432. https://doi.org/10.1002/path.1791
  35. Shu HB, Joshi HC (1995) Gamma-tubulin can both nucleate microtubule assembly and self-assemble into novel tubular structures in mammalian cells. J Cell Biol 130: 1137-1147. https://doi.org/10.1083/jcb.130.5.1137
  36. Spankuch-Schmitt B, Bereiter-Hahn J, Kaufmann M, Strebhardt K (2002) Effect of RNA silencing of polo like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells. J Natl Cancer Inst 94:1863-1877. https://doi.org/10.1093/jnci/94.24.1863
  37. Strebhardt K, Ullrich A (2006) Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer 6:321-330. https://doi.org/10.1038/nrc1841
  38. Sunkel CE, Gomes R, Sampaio P, Perdigao J, Gonzalez C (1995) Gamma-tubulin is required for the structure and function of the microtubule organizing centre in Drosophila neuroblasts. EMBO J 14:28-36.
  39. Tokumitsu Y, Mori M, Tanaka S, Akazawa K, Nakano S, Niho Y (1999) Prognostic significance of polo-like kinase expression in esophageal carcinoma. Int J Oncol 15:687-692.
  40. Warnke S, Kemmler S, Hames RS, Tsai HL, Hoffmann- Rohrer U, Fry AM, Hoffmann I (2004) Polo-like kinase-2 is required for centriole duplication in mammalian cells. Curr Biol 14:1200-1207. https://doi.org/10.1016/j.cub.2004.06.059
  41. Wolf G, Elez R, Doermer A, Holtrich U, Ackermann H, Stutte HJ, Altmannsberger HM, Rubsamen-Waigmann H, Strebhardt K (1997) Prognostic significance of pololike kinase (PLK) expression in non-small cell lung cancer. Oncogene 14:543-549. https://doi.org/10.1038/sj.onc.1200862
  42. Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001) Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway. J Biol Chem 276:43305-43312. https://doi.org/10.1074/jbc.M106050200
  43. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL (2003) A role for Plk1 phosphorylation of NudC in cytokinesis. Dev Cell 5:127-138. https://doi.org/10.1016/S1534-5807(03)00186-2
  44. Zimmerman WC, Erikson RL (2007) Finding Plk3. Cell Cycle 6:1314-1318. https://doi.org/10.4161/cc.6.11.4275