Journal of Acupuncture Research

  • 제31권1호
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  • Pages.51-60
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  • 2014
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  • 2586-288X(pISSN)
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  • 2586-2898(eISSN)
대한침구의학회 (Korean Acupuncture & Moxibustion Medicine Society)
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음곡에 시술한 택사 약침이 LPS로 유도된 흰쥐의 신장염에 미치는 영향

The Effect of Alismatis Rhizoma Herbal-acupuncture at $KI_{10}$ on LPS-induced Nephritis in Rats

  • 한제근 (대전대학교 한의과대학 경락경혈학교실) ;
  • 김양섭 (대전대학교 한의과대학 경락경혈학교실) ;
  • 김병수 (대전대학교 한의과대학 경락경혈학교실) ;
  • 임윤경 (대전대학교 한의과대학 경락경혈학교실)
  • Han, Je Geun (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University) ;
  • Kim, Yang Seob (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University) ;
  • Kim, Byung Soo (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University) ;
  • Yim, Yun Kyoung (Department of Meridian and Acupoint, College of Korean Medicine, Daejeon University)
  • 투고 : 2014.02.06
  • 심사 : 2014.02.14
  • 발행 : 2014.03.20
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초록

Objectives : This study aimed to evaluate the effects of Alismatis Rhizoma Herbal-acupuncture( AR-HA) at $KI_{10}$(Umgok) on nephritis induced by lipopolysaccharide(LPS) in rat. Methods : Rats were injected with LPS to induce nephritis. The rats in $KI_{10}$-AR-HA group were treated with AR-HA, $KI_{10}$-NP group with needle prick, $KI_{10}$-saline group with normal saline injection respectively at $KI_{10}$ three times for a week. Several experimental items were performed including measurements of the numbers of RBC, WBC, neutrophil in blood, the levels of creatinine, $TNF-{\alpha}$, CINC-1 in serum, creatinine, total protein in urine, MPO in kidney. Results : Needle prick stimulation at $KI_{10}$ significantly reduced WBC in blood of LPS-stimulated rats. Saline injection at $KI_{10}$ significantly reduced WBC in blood, $TNF-{\alpha}$ in serum, total protein in urine of LPS-stimulated rats. AR-HA at $KI_{10}$ significantly reduced WBC, neutrophil in blood, $TNF-{\alpha}$, CINC-1 in serum, creatinine, total protein in urine of LPS-stimulated rats. Conclusion : AR-HA at $KI_{10}$ has a therapeutic effect on nephritis in LPS-stimulated rat. There may be a synergism between $KI_{10}$(Umgok) stimulation and AR-HA solution.

키워드

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