Biomaterials and Biomechanics in Bioengineering

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Coating defects in polymer-coated drug-eluting stents

  • Bedair, Tarek M. (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Cho, Youngjin (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Park, Bang Ju (Department of Electronic Engineering & Institute of Gachon Fusion Technology, Gachon University) ;
  • Joung, Yoon Ki (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology) ;
  • Han, Dong Keun (Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology)
  • Received : 2014.09.18
  • Accepted : 2014.09.23
  • Published : 2014.09.25
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Abstract

Vascular stenting has a great attention as a treatment for coronary arteries diseases as compared with percutaneous balloon angioplasty. In-stent restenosis and thrombosis are side effects resulting from using bare metal stent (BMS). Employing platelet therapy allowed to reduce the rate of thrombosis, however, the rate of restenosis remains a major problem. In 2002, drug-eluting stents (DESs) were introduced as an effort to reduce the restenosis. The commercially available DESs continue to suffer from coating defects that might lead to a series of adverse effects. Most importantly, multiple concerns remain regarding the polymer coating integrity on metal surfaces or the relation of polymer irregularities to longterm adverse events.

Keywords

Acknowledgement

Supported by : National Research Foundation of Korea

References

  1. Adenier, A., Bernard, M.C., Chehimi, M.M., Cabet-Deliry, E., Desbat, B., Fagebaume, O., Pinson, J. and Podvorica, F. (2001), "Covalent modification of iron surfaces by electrochemical reduction of aryldiazonium salts", J. Am. Chem. Soc., 123(19), 4541-4549. https://doi.org/10.1021/ja003276f
  2. Alfonso, F., Perez-Vizcayno, M.J., Cruz, A., Garcia, J., Jimenez-Quevedo, P., Escaned, J. and Hernandez, R. (2009), "Treatment of patients with in-stent restenosis", Euro Intervention: journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 5, D70-8.
  3. Axel, D.I., Kunert, W., Goeggelmann, C., Oberhoff, M., Herdeg, C., Kuettner, A., Wild, D.H., Brehm, B.R., Riessen, R., Koeveker, G. and Karsch, K.R. (1997), "Paclitaxel inhibits arterial smooth muscle cell proliferation and migration in vitro and in vivo using local drug delivery", Circulation, 96(2), 636-645. https://doi.org/10.1161/01.CIR.96.2.636
  4. Balss, K.M., Veselov, V., Li, H.Q., Akerman-Revis, E., Cohen, J.H., Interbitzen, M., Alvarez, J., Wendel, C., Pottinger-Cooper, E., Chisholm, M.F., O'Brien, R., Garcia-Tunon, S., Papandreou, G. and Maryanoff, C.A. (2012), "Quantitative surface defect analysis of drug-eluting coronary stents by scanning electron microscopy: Coating integrity of the cypher sirolimus-eluting coronary stent", Anal. Meth., 4(12), 3968-3973. https://doi.org/10.1039/c2ay25031d
  5. Basalus, M.W.Z., Ankone, M.J.K., van Houwelingen, K.G., de Man, F. and von Birgelen, C. (2009a), "Coating irregularities of durable polymer-based drug-eluting stents as assessed by scanning electron microscopy", Eurointervention, 5(1), 157-165. https://doi.org/10.4244/EIJV5I1A24
  6. Basalus, M.W.Z., van Houwelingen, K.G., Ankone, M., de Man, F. and von Birgelen, C. (2009b), "Scanning electron microscopic assessment of the biodegradable coating on expanded biolimus-eluting stents", Eurointervention, 5(4), 505-510. https://doi.org/10.4244/EIJV5I4A80
  7. Basalus, M.W.Z., Tandjung, K., van, H.K.G., Stoel, M.G., de, M.F.H.A.F., Louwerenburg, J.W., Said, S.A.M., Linssen, G.C.M., Kleijne, M.A.W.J., van der Palen, J., Huisman, J., Verhorst, P.M.J. and von, B.C. (2010), "Twente study: The real-world endeavor resolute versus xience v drug-eluting stent study in twente: Study design, rationale and objectives", Neth. Heart J., 18(7), 360-364. https://doi.org/10.1007/BF03091792
  8. Basalus, M.W.Z., Tandjung, K., van, W.T., Sen, H., van, D.J.P.K.N., Grijpma, D.W., van, A.A.A. and von, B.C. (2012), "Scanning electron microscopic assessment of coating irregularities and their precursors in unexpanded durable polymer-based drug-eluting stents", Catheter. Cardiovasc. Interv., 79(4), 644-653. https://doi.org/10.1002/ccd.23273
  9. Bedair, T.M., Cho, Y., Joung, Y.K. and Han, D.K. (2014a), "Biodegradable polymer brush as nanocoupled interface for improving the durability of polymer coating on metal surface", Colloids Surf. B Biointerfaces, 122, 808-817. https://doi.org/10.1016/j.colsurfb.2014.08.025
  10. Bedair, T.M., Cho, Y., Kim, T.J., Kim, Y.D., Park, B.J., Joung, Y.K. and Han, D.K. (2014b), "Reinforcement of interfacial adhesion of a coated polymer layer on a cobalt-chromium surface for drugeluting stents", Langmuir, 30(27), 8020-8028. https://doi.org/10.1021/la501990p
  11. Bertrand, O., Jerome, R., Gautier, S., Maquet, V., Detrembleur, C., Jerome, C., Voccia, S., Claes, M., Lou, X. and Labaye, D.E. (2002), "Process for depositing strong adherend polymer coating onto an electrically conductive surface and coating use", Publication No. AU 2002317800, 16-Dec-2002, Australia.
  12. Biondi-Zoccai, G.G.L., Moretti, C., Lotrionte, M. and Sheiban, I. (2008), "Safety of drug-coated stents", Expert Opin. Drug Saf., 7(5), 597-606. https://doi.org/10.1517/14740338.7.5.597
  13. Butt, M., Connolly, D. and Lip, G.Y.H. (2009), "Drug-eluting stents: A comprehensive appraisal", Future Cardiol., 5(2), 141-157. https://doi.org/10.2217/14796678.5.2.141
  14. Byrne, R.A., Joner, M. and Kastrati, A. (2009), "Polymer coatings and delayed arterial healing following drug-eluting stent implantation", Minerva Cardioangiol., 57(5), 567-584.
  15. Cheng, P., Sundar, R., Patel, K.A. and Udipi, K. (2006), U.S. Patent No. 7,001,421. Washington, DC: U.S. Patent and Trademark Office., USA.
  16. Chevalier, B., Di,M.C., Neumann, F.J., Ribichini, F., Urban, P., Popma, J.J., Fitzgerald, P.J., Cutlip, D.E., Williams, D.O., Ormiston, J., Grube, E., Whitbourn, R. and Schwartz, L.B. (2008), "A randomized, controlled, multicenter trial to evaluate the safety and efficacy of zotarolimus- versus paclitaxel-eluting stents in de novo occlusive lesions in coronary arteries the zomaxx i trial", JACC Cardiovasc. Interv., 1(5), 524-532. https://doi.org/10.1016/j.jcin.2008.08.010
  17. Cho, Y., Vu, B.Q., Bedair, T.M., Park, B.J., Joung, Y.K. and Han, D.K. (2014), "Crack prevention of biodegradable polymer coating on metal facilitated by a nano-coupled interlayer", J. Bioact. Compat. Pol., 29, 515-526. https://doi.org/10.1177/0883911514547094
  18. Choi, J., Cho, S.B., Lee, B.S., Joung, Y.K., Park, K. and Han, D.K. (2011), "Improvement of interfacial adhesion of biodegradable polymers coated on metal surface by nanocoupling", Langmuir, 27(23), 14232-14239. https://doi.org/10.1021/la2030318
  19. Cook, S., Ladich, E., Nakazawa, G., Eshtehardi, P., Neidhart, M., Vogel, R., Togni, M., Wenaweser, P., Billinger, M., Seiler, C., Gay, S., Meier, B., Pichler, W.J., Juni, P., Virmani, R. and Windecker, S. (2009), "Correlation of intravascular ultrasound findings with histopathological analysis of thrombus aspirates in patients with very late drug-eluting stent thrombosis", Circulation, 120(5), 391-399. https://doi.org/10.1161/CIRCULATIONAHA.109.854398
  20. Costa, J.R., Jr., Abizaid, A., Costa, R., Feres, F., Tanajura, L.F., Abizaid, A., Mattos, L.A., Staico, R., Siqueira, D., Sousa, A.G.M.R., Bonan, R. and Sousa, J.E. (2008a), "Preliminary results of the hydroxyapatite nonpolymer-based sirolimus-eluting stent for the treatment of single de novo coronary lesions a first-in-human analysis of a third-generation drug-eluting stent system", Cardiovasc. Interv., JACC, 1(5), 545-551. https://doi.org/10.1016/j.jcin.2008.07.003
  21. Costa, J.R., Jr., Abizaid, A., Feres, F., Costa, R., Seixas, A.C., Maia, F., Abizaid, A., Tanajura, L.F., Staico, R., Siqueira, D., Meredith, L., Bhat, V., Yan, J., Ormiston, J., Sousa, A.G.M.R., Fitzgerald, P. and Sousa, J.E. (2008b), "Excella first-in-man (fim) study: Safety and efficacy of novolimus-eluting stent in de novo coronary lesions", EuroIntervention, 4(1), 53-58. https://doi.org/10.4244/EIJV4I1A10
  22. Costa, J.R., Jr., Abizaid, A., Costa, R., Feres, F., Tanajura, L.F., Abizaid, A., Maldonado, G., Staico, R., Siqueira, D., Sousa, A.G.M.R., Bonan, R. and Sousa, J.E. (2009), "1-year results of the hydroxyapatite polymer-free sirolimus-eluting stent for the treatment of single de novo coronary lesions: The vestasync i trial", Cardiovasc. Interv., JACC, 2(5), 422-427. https://doi.org/10.1016/j.jcin.2009.02.009
  23. Danzi, G.B., Chevalier, B., Ostojic, M., Hamilos, M. and Wijns, W. (2010), "Nobori(R) drug eluting stent system: Clinical evidence update", Minerva Cardioangiol., 58(5), 599-610.
  24. Davlouros, P.A., Nikokiris, G., Karantalis, V., Mavronasiou, E., Xanthopoulou, I., Damelou, A., Tsigkas, G. and Alexopoulos, D. (2011), "Neointimal coverage and stent strut apposition six months after implantation of a paclitaxel eluting stent in acute coronary syndromes: An optical coherence tomography study", Int. J. Cardiol., 151(2), 155-159. https://doi.org/10.1016/j.ijcard.2010.05.004
  25. Denardo, S.J., Carpinone, P.L., Vock, D.M., Batich, C.D. and Pepine, C.J. (2012), "Changes to polymer surface of drug-eluting stents during balloon expansion", J. Am. Med. Assoc., 307(20), 2148-2150.
  26. Doostzadeh, J., Clark, L.N., Bezenek, S., Pierson, W., Sood, P.R. and Sudhir, K. (2010), "Recent progress in percutaneous coronary intervention: Evolution of the drug-eluting stents, focus on the xience v drugeluting stent", Coron. Artery Dis., 21(1), 46-56. https://doi.org/10.1097/MCA.0b013e328333f550
  27. Fischman, D.L., Leon, M.B., Baim, D.S., Schatz, R.A., Savage, M.P., Penn, I. and Goldberg, S. (1994), "A randomized comparison of coronary-stent placement and balloon angioplasty in the treatment of coronary artery disease", New England J. Med., 331(8), 496-501. https://doi.org/10.1056/NEJM199408253310802
  28. Gao, Z., Yang, Y.J., Chen, J.L., Qiao, S.B., Xu, B., Qin, X.W., Yao, M., Liu, H.B., Wu, Y.J., Yuan, J.Q., Chen, J., You, S.J., Li, J.J. and Gao, R.L. (2008), "Outcome of patients implanted with bioabsorbable polymer sirolimus-eluting stent (excel) and the durable polymer sirolimus-eluting stent (cypher)", Zhonghua Xin Xue Guan Bing Za Zhi, 36(12), 1074-1077.
  29. Garg, S. and Serruys, P.W. (2010), "Coronary stents: Looking forward", J. Am. Coll. Cardiol., 56(10s1), S43-S78. https://doi.org/10.1016/j.jacc.2010.06.008
  30. Ge, J., Qian, J., Wang, X., Wang, Q., Yan, W., Yan, Y., Fan, B., Ge, L. and Liu, X. (2007), "Effectiveness and safety of the sirolimus-eluting stents coated with bioabsorbable polymer coating in human coronary arteries", Catheter. Cardiovasc. Interv., 69(2), 198-202. https://doi.org/10.1002/ccd.20926
  31. Gianrossi, R., Detrano, R., Colombo, A. and Froelicher, V. (1990), "Cardiac fluoroscopy for the diagnosis of coronary artery disease: A meta analytic review", Am. Heart J., 120(5), 1179-1188. https://doi.org/10.1016/0002-8703(90)90134-J
  32. Grube, E. and Buellesfeld, L. (2006), "Biomatrix biolimus a9-eluting coronary stent: A next-generation drug-eluting stent for coronary artery disease", Expert Rev. Med. Devices, 3(6), 731-741. https://doi.org/10.1586/17434440.3.6.731
  33. Grube, E., Schofer, J., Hauptmann, K.E., Nickenig, G., Curzen, N., Allocco, D.J. and Dawkins, K.D. (2010), "A novel paclitaxel-eluting stent with an ultrathin abluminal biodegradable polymer 9-month outcomes with the jactax hd stent", Cardiovasc. Interv., JACC, 3(4), 431-438.
  34. Guagliumi, G., Sirbu, V., Musumeci, G., Bezerra, H.G., Aprile, A., Kyono, H., Fiocca, L., Matiashvili, A., Lortkipanidze, N., Vassileva, A., Popma, J.J., Allocco, D.J., Dawkins, K.D., Valsecchi, O. and Costa, M.A. (2010), "Strut coverage and vessel wall response to a new-generation paclitaxel-eluting stent with an ultrathin biodegradable abluminal polymer: Optical coherence tomography drug-eluting stent investigation (octdesi)", Circ.: Cardiovasc. Interv., 3(4), 367-375. https://doi.org/10.1161/CIRCINTERVENTIONS.110.950154
  35. Hanefeld, P., Westedt, U., Wombacher, R., Kissel, T., Schaper, A., Wendorff, J.H. and Greiner, A. (2006), "Coating of poly(p-xylylene) by PLA-PEO-PLA triblock copolymers with excellent polymer-polymer adhesion for stent applications", Biomacromolecules, 7(7), 2086-2090. https://doi.org/10.1021/bm050642k
  36. Hwang, C.W., Levin, A.D., Jonas, M., Li, P.H. and Edelman, E.R. (2005), "Thrombosis modulates arterial drug distribution for drug-eluting stents", Circulation, 111(13), 1619-1626. https://doi.org/10.1161/01.CIR.0000160363.30639.37
  37. Jain, A.K., Lotan, C., Meredith, I.T., Feres, F., Zambahari, R., Sinha, N. and Rothman, M.T. (2010), "Twelve-month outcomes in patients with diabetes implanted with a zotarolimus-eluting stent: Results from the e-five registry", Heart, 96(11), 848-853. https://doi.org/10.1136/hrt.2009.184150
  38. Jerome, C., Aqil, A., Voccia, S., Labaye, D.E., Maquet, V., Gautier, S., Bertrand, O.F. and Jerome, R. (2006), "Surface modification of metallic cardiovascular stents by strongly adhering aliphatic polyester coatings", J. Biomed. Mater. Res., Part A, 76(3), 521-529.
  39. Joner, M., Nakazawa, G., Finn, A.V., Quee, S.C., Coleman, L., Acampado, E., Wilson, P.S., Skorija, K., Cheng, Q., Xu, X., Gold, H.K., Kolodgie, F.D. and Virmani, R. (2008), "Endothelial cell recovery between comparator polymer-based drug-eluting stents", J. Am. Coll. Cardiol., 52(5), 333-342. https://doi.org/10.1016/j.jacc.2008.04.030
  40. Joung, Y.K., Jang, B.N., Kang, J.H. and Han, D.K. (2014), "Precise ultrasonic coating and controlled release of sirolimus with biodegradable polymers for drug-eluting stent", Biomater. Biomed. Eng., 1, 13-25. https://doi.org/10.12989/bme.2014.1.1.013
  41. Kavanagh, C.A., Rochev, Y.A., Gallagher, W.M., Dawson, K.A. and Keenan, A.K. (2004), "Local drug delivery in restenosis injury: Thermoresponsive co-polymers as potential drug delivery systems", Pharmacol. Ther., 102(1), 1-15. https://doi.org/10.1016/j.pharmthera.2003.01.001
  42. Kereiakes, D.J., Cannon, L.A., Ormiston, J.A., Turco, M.A., Mann, T., Mishkel, G.J., McGarry, T., Wang, H., Underwood, P. and Dawkins, K.D. (2011), "Propensity-matched patient-level comparison of the taxus liberte and taxus element (ion) paclitaxel-eluting stents", Am. J. Cardiol., 108(6), 828-837. https://doi.org/10.1016/j.amjcard.2011.05.011
  43. Lange, R.A. and Hillis, L.D. (2010), "Second-generation drug-eluting coronary stents", N. Engl. J. Med., 362(18), 1728-1730. https://doi.org/10.1056/NEJMe1001069
  44. Levy, Y., Mandler, D., Weinberger, J. and Domb, A.J. (2009a), "Evaluation of drug-eluting stents' coating durability-clinical and regulatory implications", J. Biomed. Mater. Res., Part B, 91(1), 441-451.
  45. Levy, Y., Tal, N., Tzemach, G., Weinberger, J., Domb, A.J. and Mandler, D. (2009b), "Drug-eluting stent with improved durability and controllability properties, obtained via electrocoated adhesive promotion layer", J. Biomed. Mater. Res., Part B, 91(2), 819-830.
  46. Lopez, J.J., Keyes, M.J., Nathan, S., Piana, R., Pencina, M., Dhar, G., Marso, S., Rao, S., Shammo, S., Marquardt, W., Cohen, D.J. and Kleiman, N.S. (2010), "Rapid adoption of drug-eluting stents: Clinical practices and outcomes from the early drug-eluting stent era", Am. Heart J., 160, 767-774. https://doi.org/10.1016/j.ahj.2010.06.048
  47. Mani, G., Feldman, M.D., Patel, D. and Agrawal, C.M. (2007), "Coronary stents: A materials perspective", Biomater., 28, 1689-1710. https://doi.org/10.1016/j.biomaterials.2006.11.042
  48. Martin, D.M. and Boyle, F.J. (2011), "Drug-eluting stents for coronary artery disease: A review", Med. Eng. Phys., 33, 148-163. https://doi.org/10.1016/j.medengphy.2010.10.009
  49. Mehilli, J., Kastrati, A., Wessely, R., Dibra, A., Hausleiter, J., Jaschke, B., Dirschinger, J. and Schoemig, A. (2006), "Randomized trial of a nonpolymer-based rapamycin-eluting stent versus a polymer-based paclitaxel-eluting stent for the reduction of late lumen loss", Circulation, 113, 273-279. https://doi.org/10.1161/CIRCULATIONAHA.105.575977
  50. Miesserov, K.G. (1966), "Mechanism of polymerization of $\alpha$-olefins on oxide catalysts", J. Polym. Sci., Part A-1: Polym. Chem., 4(12), 3047-3054. https://doi.org/10.1002/pol.1966.150041211
  51. Okner, R., Domb, A.J. and Mandler, D. (2007), "Electrochemical formation and characterization of copolymers based on n-pyrrole derivatives", Biomacromolecules, 8(9), 2928-2935. https://doi.org/10.1021/bm7004752
  52. Okner, R., Shaulov, Y., Tal, N., Favaro, G., Domb, A.J. and Mandler, D. (2009), "Electropolymerized tricopolymer based on n-pyrrole derivatives as a primer coating for improving the performance of a drugeluting stent", ACS Appl. Mater. Interfaces, 1, 758-767. https://doi.org/10.1021/am800139s
  53. Otsuka, Y., Chronos, N.A., Apkarian, R.P. and Robinson, K.A. (2007), "Scanning electron microscopic analysis of defects in polymer coatings of three commercially available stents: Comparison of biodivysio, taxus and cypher stents", J. Invasive Cardiol., 19, 71-76.
  54. Parker, T., Dave, V. and Falotico, R. (2010), "Polymers for drug eluting stents", Curr. Pharm. Des., 16, 3978-3988. https://doi.org/10.2174/138161210794454897
  55. Pinson, J. and Podvorica, F. (2005), "Attachment of organic layers to conductive or semiconductive surfaces by reduction of diazonium salts", Chem. Soc. Rev., 34, 429-439. https://doi.org/10.1039/b406228k
  56. Reifart, N., Hauptmann, K.E., Rabe, A., Enayat, D. and Giokoglu, K. (2010), "Short and long term comparison (24 months) of an alternative sirolimus-coated stent with bioabsorbable polymer and a bare metal stent of similar design in chronic coronary occlusions: The coracto trial", Euro. Intervention, 6, 356-360.
  57. Serruys, P.W., Luijten, H.E., Beatt, K.J., Geuskens, R., de, F.P.J., van, d.B.M., Reiber, J.H., ten, K.H.J., van, E.G.A. and Hugenholtz, P.G. (1988), "Incidence of restenosis after successful coronary angioplasty: A time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months", Circulation, 77(2), 361-371. https://doi.org/10.1161/01.CIR.77.2.361
  58. Serruys, P.W., de, J.P., Kiemeneij, F., Macaya, C., Rutsch, W., Heyndrickx, G., Emanuelsson, H., Marco, J., Legrand, V., Materne, P. and Morel, M.A. (1994), "A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. Benestent study group", N. Engl. J. Med., 331(8), 489-495. https://doi.org/10.1056/NEJM199408253310801
  59. Shaulov, Y., Okner, R., Levi, Y., Tal, N., Gutkin, V., Mandler, D. and Domb, A.J. (2009), "Poly(methyl methacrylate) grafting onto stainless steel surfaces: Application to drug-eluting stents", ACS Appl. Mater. Interfaces, 1(11), 2519-2528. https://doi.org/10.1021/am900465t
  60. Sheiban, I., Villata, G., Bollati, M., Sillano, D., Lotrionte, M. and Biondi-Zoccai, G. (2008), "Nextgeneration drug-eluting stents in coronary artery disease: Focus on everolimus-eluting stent (xience v)", Vasc. Health Risk Manag., 4(1), 31-38. https://doi.org/10.2147/vhrm.2008.04.01.31
  61. Sousa, J.E., Costa, M.A., Abizaid, A.C., Rensing, B.J., Abizaid, A.S., Tanajura, L.F., Kozuma, K., Van, L.G., Sousa, A.G., Falotico, R., Jaeger, J., Popma, J.J. and Serruys, P.W. (2001), "Sustained suppression of neointimal proliferation by sirolimus-eluting stents: One-year angiographic and intravascular ultrasound follow-up", Circulation, 104(17), 2007-2011. https://doi.org/10.1161/hc4201.098056
  62. Stella, P.R., Mueller, R., Pavlakis, G., De, B.B., Hauptmann, K., Morice, M.C., Chevalier, B., Fajadet, J., Sievert, H. and Grube, E. (2008), "One year results of a new in situ length-adjustable stent platform with a biodegradable biolimus a9 eluting polymer: Results of the custom-ii trial", Euro. Intervention, 4(2), 200-207.
  63. Teomim, D., Fishbien, I., Golomb, G., Orloff, L., Mayberg, M. and Domb, A.J. (1999), "Perivascular delivery of heparin for the reduction of smooth muscle cell proliferation after endothelial injury", J. Control. Release, 60(1), 129-142. https://doi.org/10.1016/S0168-3659(99)00071-1
  64. Tesfamariam, B. (2007), "Local vascular toxicokinetics of stent-based drug delivery", Toxicol. Lett., 168(2), 93-102. https://doi.org/10.1016/j.toxlet.2006.11.013
  65. Unger, F., Westedt, U., Hanefeld, P., Wombacher, R., Zimmermann, S., Greiner, A., Ausborn, M. and Kissel, T. (2007), "Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings?", J. Control. Release, 117(3), 312-321. https://doi.org/10.1016/j.jconrel.2006.11.003
  66. Verheye, S., Agostoni, P., Dubois, C. L., Dens, J., Ormiston, J., Worthley, S., Trauthen, B., Hasegawa, T., Koo, B.K., Fitzgerald, P.J., Mehran, R. and Lansky, A.J. (2009), "9-month clinical, angiographic, and intravascular ultrasound results of a prospective evaluation of the axxess self-expanding biolimus a9-eluting stent in coronary bifurcation lesions: The diverge (drug-eluting stent intervention for treating side branches effectively) study", J. Am. Coll. Cardiol., 53(12), 1031-1039. https://doi.org/10.1016/j.jacc.2008.12.012
  67. Virmani, R., Guagliumi, G., Farb, A., Musumeci, G., Grieco, N., Motta, T., Mihalcsik, L., Tespili, M., Valsecchi, O. and Kolodgie, F.D. (2004), "Localized hypersensitivity and late coronary thrombosis secondary to a sirolimus-eluting stent should we be cautious?", Circulation, 109(6), 701-705. https://doi.org/10.1161/01.CIR.0000116202.41966.D4
  68. Waseda, K., Hasegawa, T., Ako, J., Honda, Y., Grube, E., Whitbourn, R., Ormiston, J., O'Shaughnessy, C.D., Henry, T.D., Overlie, P., Schwartz, L.B., Sudhir, K., Chevalier, B., Gray, W.A., Yeung, A.C. and Fitzgerald, P.J. (2010), "Comparison of vascular response to zotarolimus-eluting stent vs paclitaxeleluting stent implantation: Pooled ivus results from the zomaxx i and ii trials", Circ. J., 74(11), 2334-2339. https://doi.org/10.1253/circj.CJ-09-0850
  69. Waseda, K., Ako, J., Yamasaki, M., Koizumi, T., Sakurai, R., Hongo, Y., Koo, B.K., Ormiston, J., Worthley, S.G., Whitbourn, R.J., Walters, D.L., Meredith, I.T., Fitzgerald, P.J. and Honda, Y. (2011), "Impact of polymer formulations on neointimal proliferation after zotarolimus-eluting stent with different polymers: Insights from the resolute trial", Circ. Cardiovasc. Interv., 4(3), 248-255. https://doi.org/10.1161/CIRCINTERVENTIONS.110.957548
  70. Wiemer, M., Butz, T., Schmidt, W., Schmitz, K. P., Horstkotte, D. and Langer, C. (2010), "Scanning electron microscopic analysis of different drug eluting stents after failed implantation: From nearly undamaged to major damaged polymers", Catheter. Cardiovasc. Interv., 75(6), 905-911.
  71. Wykrzykowska, J.J., Onuma, Y. and Serruys, P.W. (2009), "Advances in stent drug delivery: The future is in bioabsorbable stents", Expert Opin. Drug Delivery, 6(2), 113-126. https://doi.org/10.1517/17425240802668495
  72. Yazdani, S.K., Vorpahl, M., Nakano, M., Su, S.H., Kolodgie, F.D. and Virmani, R. (2011), "In vitro and in vivo characterisation of biodegradable polymer-based drug-eluting stent", Euro. Intervention, 7(7), 835-843.

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