Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Antioxidant activity and anti-obesity effect of Coprinus comatus in Zucker rat (fa/fa)

먹물버섯(Coprinus comatus )의 항산화 활성 및 Zucker rat에 대한 항비만 효과

  • Lee, Soo-Jung (Department of Foods and Nutrition, Gyeongsang National University) ;
  • Park, Hyoung Joon (Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • Song, Yuno (Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • Jang, Sun-Hee (Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • Goo, Ae Jin (Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University) ;
  • Ko, Yeoung-Gyu (Animal Genetic Resources Station, National Institute of Animal Science, RDA) ;
  • Cho, Jae-Hyeon (Institute of Life Science, College of Veterinary Medicine, Gyeongsang National University)
  • 이수정 (경상대학교 식품영양학과) ;
  • 박형준 (경상대학교 수의학과.생명과학연구원) ;
  • 송윤오 (경상대학교 수의학과.생명과학연구원) ;
  • 장선희 (경상대학교 수의학과.생명과학연구원) ;
  • 구애진 (경상대학교 수의학과.생명과학연구원) ;
  • 고응규 (농촌진흥청 축산과학원) ;
  • 조재현 (경상대학교 수의학과.생명과학연구원)
  • Received : 2014.02.05
  • Accepted : 2014.03.07
  • Published : 2014.03.30
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Abstract

The aim of the study was to investigate the anti-obesity effect of Coprinus comatus (CC) in high-fat diet-fed Zucker rat (fa/fa). Obesity was induced by feeding on high-fat diet (HFD) containing 60% kcal fat for 10 weeks, in which CC extracts were administrated through the gastrointestinal tract at a concentration of 200 mg/kg BW/day for 10 weeks. The total polyphenol and flavonoid contents of CC extracts were found to be $18.5{\pm}1.1mg$ of catechin equivalent/g, and $5.24{\pm}0.54mg$ of quercetin equivalent/g extract, respectively. The DPPH, ABTS, and hydroxyl radical scavenging activities of CC extracts were 15.34 %, 17.25%, and 16.18%, respectively. In animal study, CC administration significantly reduced the body weight, while there were no significant differences in the daily food intake between the HFD-fed Zucker rats and HFD plus CC-fed rats. CC treatment decreased epididymal and perirenal fat weights in HFD-fed Zucker rats. Significant decreases in the levels of triglyceride and total cholesterol in the serum and liver were observed in the CC-treated group compared with HFD-fed Zucker rats. Serum HDL-cholesterol levels in the CC-treated group were increased compared with the HFD-fed groups. Serum AST and ALT activities in the CC group were significantly lower than those of the HFD-fed group. Taken together, these data demonstrated that CC has potential in preventing high-fat diet induced obesity and is a good candidate for an anti-obesity agent.

Keywords

References

  1. Ahn DK. 1992. Medicinal fungi in Korea. Kor J Mycol 20: 154-166.
  2. Ancerewicz JE, Migliavacca PA, Carrupt B, Testa F, Bree R, Zini JP, Tillernent S, Labidalle D, Guyot AM. 1998. Chauvent-Monges., Crevat, A. and Ridant, A. L. : Structure property relationships of trimetazidine derivatives and model compounds as potential antioxidants. Free Radical Bio Med 25: 113-120. https://doi.org/10.1016/S0891-5849(98)00072-0
  3. Beck B, Musse N, Stricker-Krongrad A. 2002. Bhrelin, macronutrient intake and dietary preferences in long-evans rats. Biochem Biophys Res Comm 292: 1031-1035. https://doi.org/10.1006/bbrc.2002.6737
  4. Blois MS. 1958. Antioxidant determination by the use of a stable free radical. Nature 181: 1199-1200 https://doi.org/10.1038/1811199a0
  5. Cheung PCK. 1996. The hypercholesterolemic effect of two edible mushrooms: Auricularia aurivula (tree-ear) and Tremella fuciformis (white jelly-leaf) in hypercholesterolemic rats. Nutr Res 16: 1721-1725. https://doi.org/10.1016/0271-5317(96)00191-1
  6. Choi JH, Park SH, Kim DI, Kim JM, Kim CNM, Kim GP. 2001. Effects of edible Lentinus tuber-regium on the obesity and lipid metabolism of SD rats. The Korean J Mycology 29: 47-51.
  7. Choi YM, Kim MH, Shin JJ, Park JM, Lee JS. 2003. The antioxidant activities of some commercial test. J Korean Soc Food Sci Nutr 32: 723-727. https://doi.org/10.3746/jkfn.2003.32.5.723
  8. Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL. 1996. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271: 994-6. https://doi.org/10.1126/science.271.5251.994
  9. De Artinano A, Castro M. 2009. Experimental rat models to study the metabolic syndrome. Br J Nutr 9: 1246-1253.
  10. Grundy SM. 1998. Multifactorial causation of obesity: implications for prevention. Am J Clin Nutr 67: 563S-572S.
  11. Gutfinger T. 1981. Polyphenols in olive oil. J Am Oil Chem Soc 58: 966-968. https://doi.org/10.1007/BF02659771
  12. Gutteridge JM. 1984. Reactivity of hydroxyl and hydroxyllike radicals discriminated by release of thiobarbituric acid reactive material from deoxy sugars, nucleosides and benzoate. Biochem J 224: 761-767.
  13. Hong MH, Jin YJ, Pyo YH. 2012. Antioxidant properties and ubiquinone contents in different parts of several commercial mushrooms. J Korean Soc Food Sci Nutr 41: 1235-1241. https://doi.org/10.3746/jkfn.2012.41.9.1235
  14. Kim HJ, Lee BH, Kim OM, Bae JT, Park SH, Park DC, Lee KR. 1999. Antimutagenic effect of the fruiting body and the mycelia extracts of Coprinus comatus. J Korean Soc Food Sci Nutr 28: 452-457.
  15. Kim SG, Choi JW, Park HJ, Lee SM, Jung HJ. 2009. Anti-hyperlipidemic effects of the flavonoid-rich fraction from the methanol extract of Orostachy japonicas in rats. Kor J Pharmacogn 40: 51-58.
  16. Kim YD, Kim NS, Eom SY, Kim SH, Kang JW, Lee SW, Park SY, Kim JS, Kim H, Hong JS. 2008. Effects of extracts from the mushroom Keumsa Sangwhang (Phellinus linteus) on fasting blood glucose and cholesterol levels in human. Korean J Food Culture 23: 68-72.
  17. Koh JB, Lee CU. 2005. Effect of Pleurotus eryngii on lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci 34: 626-631. https://doi.org/10.3746/jkfn.2005.34.5.626
  18. Koh JB, Lee CU. 2005. Effects of Pleurotus eryngii in lipid metabolism in rats fed high fat diet. J Korean Soc Food Sci Nutr 34: 626-631. https://doi.org/10.3746/jkfn.2005.34.5.626
  19. Lee BH, Kim HJ, Chang JS, Bae JT, Park SH, Hee SO, Kim OM, Lee BR, Choi BS, Lee KR. 1999. Inhibitory effect of Coprinus comatus ethanol extract on the liver damage in Benzo(a)pyrene-treated mice. J Korean Soc Food Sci Nutr 28: 1364-1368.
  20. Lee HS, Choi JH, Kim YE, Lee CH. 2012. Effect of dietary intake of Salicornia herbacea L. hot water extract on anti- obesity in diet-induced obese rats. J Korean Soc Food Sci Nutr 41: 950-956. https://doi.org/10.3746/jkfn.2012.41.7.950
  21. Lee SJ, Kwon MH, Kwon HJ, Shin JH, Kang MJ, Kim SH, Sung NJ. 2013. Effect of red garlic-composites on the fecal lipid level and hepatic antioxidant enzyme activity in rats fed a high fat-cholesterol diet. J Korean Soc Food Sci Nutr 42: 17-25. https://doi.org/10.3746/jkfn.2013.42.1.017
  22. Lim S, Shin H, Song JH, Kwak SH, Kang SM, Won Yoon J, Choi SH, Cho SI, Park KS, Lee HK, Jang HC, Koh KK. 2011. Increasing prevalence of metabolic syndrome in Korea: the Korean National Health and Nutrition Examination Survey for 1998-2007. Diabetes care 34: 1323-1328. https://doi.org/10.2337/dc10-2109
  23. Moon SP, Koh JB. 2004. Effect lipid culture of Coriolus versicolor on lipid metabolism enzyme activities in rats fed high fat diet. Korean J Nutr 37: 88-94.
  24. Moradali MF, Mostafavi H, Ghods S, Hedjaroude GA. 2007. Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). Int Immunopharmacol 7: 701-724. https://doi.org/10.1016/j.intimp.2007.01.008
  25. Moreno MIN, Isla MI, Sampietro AR, Vattuone MA. 2000. Comparison of the free radical scavenging activity of propolis from several regions of Argentina. J Ethnopharmacol 71: 109-114. https://doi.org/10.1016/S0378-8741(99)00189-0
  26. Oh SW, Lee CU, Koh JB. 2004. Effect Agaricus blazei Murill on lipid metabolism in rats fed high fat diet. J Korean So c Food Sci Nutr 33: 821-826. https://doi.org/10.3746/jkfn.2004.33.5.821
  27. Ozsoy N, Yilmaz T, Kurt O, Can A, Yanardag R. 2009. In vitro antioxidant activity of Amaranthus lividus L. Food Chem 116: 867-872. https://doi.org/10.1016/j.foodchem.2009.03.036
  28. Park HS. 2001. Pharmacological therapy of obesity. Kor J Soc Study Obes 10: 118-127.
  29. Park JO, Jang HW. 2009. Effects of Sasa coreana, Nakai on the lipid compositions of serum in high cholesterol diet rats. J Life Sci 19: 1145-1151. https://doi.org/10.5352/JLS.2009.19.8.1145
  30. Qi Y, Zhao X, Lim YI, Park KY. 2013. Antioxidant and anticancer effects of edible and medicinal mushrooms. J Korean Soc Food Sci Nutr 42: 655-662. https://doi.org/10.3746/jkfn.2013.42.5.655
  31. Re R, Pellegrini N, Proteggente A, Pannala A, Yang M, Rice-Evans C. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26: 1231-1237. https://doi.org/10.1016/S0891-5849(98)00315-3
  32. Sarti C, Gallagher J. 2006. The metabolic syndrome: prevalence, CHD risk, and treatment. J Diabetes Complications 20: 121-132. https://doi.org/10.1016/j.jdiacomp.2005.06.014
  33. Seo EK, Kang Dh, Seo JW, Kim KS, Lee TK, Lee YC, Nam KS, Kim CH. 2000. Anti-diabetic effect of Yukmijijwangtang- Jahage in obese Zucker rats. Korean J Life Sci 10: 388-396.
  34. Valdecantos MP, Perez-Matute P, Martinez JA. 2009. Obesity and oxidative stress: role of antioxidant supplementation. Rev Invest Clin 61: 127-139.
  35. Xu XM, Jun JY, Jeong IH. 2007. A study on the antioxidant activity of Hae?Songi mushroom (Hypsizigus marmoreus) hot water extracts. J Korean Soc Food Sci Nutr 36: 1351-1357. https://doi.org/10.3746/jkfn.2007.36.11.1351
  36. Zucker LM, Antoniades HN. 1972. Insulin and obesity in the Zucker genetically obese rat 'fatty'. Endocrinology 90: 1320-1330. https://doi.org/10.1210/endo-90-5-1320
  37. Zucker TF, Zucker LM. 1962. Hereditary obesity in the rat associated with high serum fat and cholesterol. Proc Soc Exp Biol Med 110: 165-171. https://doi.org/10.3181/00379727-110-27455

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