The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Glucocorticoid Triggers an Attack of Periodic Hypokalemic Paralysis during Treatment for Diffuse Large B-cell Lymphoma

미만성 거대B세포 항암치료 중 유발된 주기적 저칼륨성 마비 1예

  • Ha, Kyung Sun (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Park, Young Jae (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Park, Sung Soo (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Lee, Joon Yub (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Kim, Ji Hyun (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Jang, Inae (Department of Internal Medicine, The Catholic University College of Medicine) ;
  • Byun, Jae Ho (Department of Internal Medicine, The Catholic University College of Medicine)
  • 하경선 (가톨릭대학교 의과대학 내과학교실) ;
  • 박영재 (가톨릭대학교 의과대학 내과학교실) ;
  • 박성수 (가톨릭대학교 의과대학 내과학교실) ;
  • 이준엽 (가톨릭대학교 의과대학 내과학교실) ;
  • 김지현 (가톨릭대학교 의과대학 내과학교실) ;
  • 장인애 (가톨릭대학교 의과대학 내과학교실) ;
  • 변재호 (가톨릭대학교 의과대학 내과학교실)
  • Received : 2013.11.20
  • Accepted : 2014.03.29
  • Published : 2014.11.01
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Abstract

Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-cell lymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, and his serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolone had provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should be administered with caution, particularly in patients with periodic paralysis.

이번 증례는 드문 예지만 항암치료를 위해 투여한 스테로이드가 주기적 저칼륨성 마비의 유발 인자로 작용할 수 있음을 보여준다. 미만성 거대B세포 림프종의 치료 중 주기적 저칼륨성 마비가 있는 경우 칼륨 수치에 대한 측정과 칼륨 보충이 필요하다.

Keywords

References

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