The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Chemotherapy in Elderly Patients with Colorectal Cancer

진행성 노인 대장암에 대한 항암요법

  • Han, Hye Sook (Department of Internal Medicine, College of Medicine, Chungbuk National University)
  • 한혜숙 (충북대학교 의과대학 내과학교실)
  • Published : 2014.11.01
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Abstract

Colorectal cancer (CRC) affects largely elderly populations. However, older patients with CRC are generally excluded from randomized clinical trials, and the healthy subjects who are recruited are not representative of the general elderly patient population. Nevertheless, recent data from clinical trials specifically targeting elderly patients and related subgroup analyses indicate that well-selected elderly patients can have a similar response to that of younger patients. Chronological age should not determine the candidacy for adjuvant or palliative chemotherapy in elderly patients with CRC. The appropriate management of healthy elderly patients would mean that they could receive aggressive chemotherapy in a similar regimen to that of younger patients, whereas the care of frail elderly patients and those with a short life expectancy should focus on palliation. The use of a comprehensive geriatric assessment could allow the use of safe and beneficial chemotherapy regimens in elderly patients with CRC.

Keywords

References

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