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A Case of Skin and Soft Tissue Infection by Mycobacterium massiliense

Mycobacterium massiliense 피부연조직 감염에서 완치한 1예

  • Kim, Tae Hoon (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Yoon, Ji Hyun (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Jin, Sung Joon (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Kim, Ki Hyun (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Cheon, Jae Young (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Yoon, Hong Jin (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Song, Young Goo (Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine)
  • 김태훈 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 윤지현 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 진성준 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 김기현 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 천재영 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 윤홍진 (연세대학교 의과대학 강남세브란스병원 내과) ;
  • 송영구 (연세대학교 의과대학 강남세브란스병원 내과)
  • Received : 2013.09.05
  • Accepted : 2013.12.27
  • Published : 2014.10.01

Abstract

Mycobacterium massiliense (M. massiliense) was identified recently as a species that separated from M. abscessus. Unlike M. abscessus, M. massiliense responds well to clarithromycin-based antibiotic treatment. Many cases of M. massiliense infections related to iatrogenic procedures have been reported. We report a case of skin and soft tissue infection by M. massiliense, which was not caused by medical appliances, that was treated successfully using clarithromycin monotherapy for -6 months after initial treatment with empirical antibiotics for 4 weeks.

평소 건강하고 어떠한 시술도 받지 않은 34세 여성이 산행 후 우측 경골 앞쪽 피부에 염증 병변 발생하여 검사를 시행 받고 M. massiliense 감염으로 진단받았다. 감수성 결과를 확인 후 6개월간 clarithromycin 단독요법으로 성공적으로 치료하였기에 보고하고자 한다.

Keywords

References

  1. Koh WJ, Jeon K, Shin SJ. Successful treatment of Mycobacterium massiliense lung disease with oral antibiotics only. Antimicrob Agents Chemother 2013;57: 1098-1100. https://doi.org/10.1128/AAC.02016-12
  2. Choi KH, Yu HM, Jeong JS, Kim SR, Lee YC. A fatal case of acute respiratory failure caused by Mycobacterium massiliense. Tuberc Respir Dis (Seoul) 2013;74:79-81. https://doi.org/10.4046/trd.2013.74.2.79
  3. Nakanaga K, Hoshino Y, Era Y, et al. Multiple cases of cutaneous Mycobacterium massiliense infection in a "hot spa" in Japan. J Clin Microbiol 2011;49:613-617. https://doi.org/10.1128/JCM.00817-10
  4. Otsuki T, Izaki S, Nakanaga K, Hoshino Y, Ishii N, Osamura K. Cutaneous Mycobacterium massiliense infection: a sporadic case in Japan. J Dermatol 2012;39:569-572. https://doi.org/10.1111/j.1346-8138.2011.01339.x
  5. Van Ingen J, de Zwaan R, Dekhuijzen RP, Boeree MJ, van Soolingen D. Clinical relevance of Mycobacterium chelonae-abscessus group isolation in 95 patients. J Infect 2009;59:324-331. https://doi.org/10.1016/j.jinf.2009.08.016
  6. Kim HY, Yun YJ, Park CG, et al. Outbreak of Mycobacterium massiliense infection associated with intramuscular injections. J Clin Microbiol 2007;45:3127-3130. https://doi.org/10.1128/JCM.00608-07
  7. Zelazny AM, Root JM, Shea YR, et al. Cohort study of molecular identification and typing of Mycobacterium abscessus, Mycobacterium massiliense, and Mycobacterium bolletii. J Clin Microbiol 2009;47:1985-1995. https://doi.org/10.1128/JCM.01688-08
  8. Koh WJ, Jeon K, Lee NY, et al. Clinical significance of differentiation of Mycobacterium massiliense from Mycobacterium abscessus. Am J Respir Crit Care Med 2011;183:405-410. https://doi.org/10.1164/rccm.201003-0395OC
  9. Cho AY, Kim YS, Kook YH, et al. Identification of cutaneous Mycobacterium massiliense infections associated with repeated surgical procedures. Ann Dermatol 2010;22:114-118. https://doi.org/10.5021/ad.2010.22.1.114
  10. Daley CL, Griffith DE. Pulmonary disease caused by rapidly growing mycobacteria. Clin Chest Med 2002;23:623-632. https://doi.org/10.1016/S0272-5231(02)00021-7