The Korean Journal of Medicine

  • 제87권4호
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  • Pages.501-504
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  • 2014
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
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Sunitinib 치료 중인 전이성 신세포암 환자에서 발생한 저혈당성 혼수

Hypoglycemic Coma in a Patient with Metastatic Renal Cell Carcinoma Treated with Sunitinib

  • 조미영 (군산의료원 내과) ;
  • 심혁 (원광대학교 의과대학 내과학교실) ;
  • 박무림 (원광대학교 의과대학 내과학교실)
  • Cho, Meyoung (Department of Internal Medicine, Gunsan Medical Center) ;
  • Shim, Hyeok (Department of Internal Medicine, Wonkwang University School of Medicine) ;
  • Park, Moo-Rim (Department of Internal Medicine, Wonkwang University School of Medicine)
  • 투고 : 2014.01.27
  • 심사 : 2014.03.28
  • 발행 : 2014.10.01
⟨ 이전 논문 다음 논문 ⟩

초록

전이성 신세포암을 진단받고 sunitinib으로 치료 중이던 2형 당뇨병 환자에서 저혈당과 저혈당에 의한 대사성 뇌병증을 경험하였다. Sunitinib은 다표적 tyrosin kinase 억제제로 전이성 신장암의 치료에 사용되고 있으며 저혈당을 유발시킬 수 있다. 비록 sunitinib과 관련된 중증 저혈당의 보고는 드물지만, sunitinib 치료를 받는 당뇨병 환자들에서 혈당 조절은 매우 면밀히 관찰되어야 할 것이다.

We present a patient with type 2 diabetes mellitus and metastatic renal cell carcinoma who developed severe hypoglycemia and metabolic encephalopathy after sunitinib treatment. Sunitinib, a multi-target tyrosine kinase inhibitor, is used to treat metastatic renal cell carcinoma. Sunitinib-induced hypoglycemia has been reported and there are rare case reports of severe hypoglycemia due to sunitinib. Therefore, glycemic control should be monitored closely in diabetic patients treated with sunitinib.

키워드

참고문헌

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  9. Lee Y, Jung HS, Choi HJ, et al. Life-threatening hypoglycemia induced by a tyrosine kinase inhibitor in a patient with neuroendocrine tumor: a case report. Diabetes Res Clin Pract 2011;93:e68-70. https://doi.org/10.1016/j.diabres.2011.04.011
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피인용 문헌

  1. Mechanisms through which diabetes mellitus influences renal cell carcinoma development and treatment: A review of the literature vol.38, pp.6, 2016, https://doi.org/10.3892/ijmm.2016.2776