Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
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Slow Coronary Flow Phenomenon and Increased Platelet Volume Indices

  • Seyyed-Mohammadzad, Mir Hossein (Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences) ;
  • Khademvatani, Kamal (Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences) ;
  • Kerachian, Abdollah (Department of Cardiology, Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences) ;
  • Eskandari, Ramin (Department of Cardiology, Firoozgar Hospital, Iran University of Medical Sciences) ;
  • Rezaei, Yousef (Seyyed-al-Shohada Heart Center, Urmia University of Medical Sciences)
  • Received : 2014.06.18
  • Accepted : 2014.08.26
  • Published : 2014.11.30
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Abstract

Background and Objectives: We sought to determine the relationship between mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) with slow coronary flow (SCF). Subjects and Methods: Eighty participants who underwent coronary angiography were divided into two groups, 50 participants with SCF as case group, and 30 with normal coronary flow (NCF) as control group. Baseline characteristics and laboratory data were collected before angiography. Results: Platelet volume indices MPV ($10.8{\pm}1.2$ fL), PDW ($14.5{\pm}2.2$ fL), and P-LCR ($30.5{\pm}8.1$%) in the SCF group were significantly (p<0.05) higher than those ($10.1{\pm}0.9$ fL, $13.2{\pm}1.8$ fL, and $26.8{\pm}6.8$%, respectively) in the NCF group. The patients with three SCF arteries had significantly higher platelet volume indices compared to those with NCF arteries; however, the patients with one SCF artery did not. Based on linear regression model, MPV, PDW, and P-LCR were independent predictors of mean infarction frame counting (TFC). In multivariate analysis, MPV {odds ratio (OR)=32.393, 95% confidence interval (CI)=1.189-882.606, p=0.039} and P-LCR (OR=0.566, 95% CI=0.330-0.937, p=0.028) were independent predictors of SCF. Conclusion: Platelet volume indices MPV, PDW, and P-LCR were associated with both the presence and extent of SCF.

Keywords

References

  1. Goel PK, Gupta SK, Agarwal A, Kapoor A. Slow coronary flow: a distinct angiographic subgroup in syndrome X. Angiology 2001;52:507-14. https://doi.org/10.1177/000331970105200801
  2. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding. Am Heart J 1972;84:66-71. https://doi.org/10.1016/0002-8703(72)90307-9
  3. Mosseri M, Yarom R, Gotsman MS, Hasin Y. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation 1986;74:964-72. https://doi.org/10.1161/01.CIR.74.5.964
  4. Li JJ, Qin XW, Li ZC, et al. Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow. Clin Chim Acta 2007;385:43-7. https://doi.org/10.1016/j.cca.2007.05.024
  5. Turhan H, Saydam GS, Erbay AR, et al. Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol 2006;108:224-30. https://doi.org/10.1016/j.ijcard.2005.05.008
  6. Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O. Simvastatin may improve myocardial perfusion abnormality in slow coronary flow. Cardiology 2008;110:39-44. https://doi.org/10.1159/000109405
  7. Gokce M, Kaplan S, Tekelioglu Y, Erdogan T, Kucukosmanoglu M. Platelet function disorder in patients with coronary slow flow. Clin Cardiol 2005;28:145-8. https://doi.org/10.1002/clc.4960280310
  8. Davì G, Patrono C. Platelet activation and atherothrombosis. N Engl J Med 2007;357:2482-94. https://doi.org/10.1056/NEJMra071014
  9. van der Loo B, Martin JF. A role for changes in platelet production in the cause of acute coronary syndromes. Arterioscler Thromb Vasc Biol 1999;19:672-9. https://doi.org/10.1161/01.ATV.19.3.672
  10. Seyyed-Mohammadzad MH, Eskandari R, Rezaei Y, et al. Prognostic value of mean platelet volume in patients undergoing elective percutaneous coronary intervention. Anadolu Kardiyol Derg 2014. DOI:10.5152/akd.2014.5169
  11. Celik T, Yuksel UC, Bugan B, et al. Increased platelet activation in patients with slow coronary flow. J Thromb Thrombolysis 2010;29:310-5. https://doi.org/10.1007/s11239-009-0353-z
  12. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14:28-32.
  13. Grotto HZ, Noronha JF. Platelet larger cell ratio (P-LCR) in patients with dyslipidemia. Clin Lab Haematol 2004;26:347-9. https://doi.org/10.1111/j.1365-2257.2004.00634.x
  14. Gibson CM, Cannon CP, Daley WL, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation 1996;93: 879-88. https://doi.org/10.1161/01.CIR.93.5.879
  15. Chu SG, Becker RC, Berger PB, et al. Mean platelet volume as a predictor of cardiovascular risk: a systematic review and meta-analysis. J Thromb Haemost 2010;8:148-56. https://doi.org/10.1111/j.1538-7836.2009.03584.x
  16. Elsherbiny IA, Shoukry A, El Tahlawi MA. Mean platelet volume and its relation to insulin resistance in non-diabetic patients with slow coronary flow. J Cardiol 2012;59:176-81. https://doi.org/10.1016/j.jjcc.2011.11.009
  17. Nurkalem Z, Alper AT, Orhan AL, et al. Mean platelet volume in patients with slow coronary flow and its relationship with clinical presentation. Turk Kardiyol Dern Ars 2008;36:363-7.
  18. Sen N, Basar N, Maden O, et al. Increased mean platelet volume in patients with slow coronary flow. Platelets 2009;20:23-8. https://doi.org/10.1080/09537100802458969
  19. Isik T, Ayhan E, Uyarel H, et al. Increased mean platelet volume associated with extent of slow coronary flow. Cardiol J 2012;19:355-62. https://doi.org/10.5603/CJ.2012.0065
  20. Albayrak S, Ordu S, Yuksel H, Ozhan H, Yazgan O, Yazici M. Efficacy of nebivolol on flow-mediated dilation in patients with slow coronary flow. Int Heart J 2009;50:545-53. https://doi.org/10.1536/ihj.50.545

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