Korean Journal of Community Nutrition (대한지역사회영양학회지)

The Korean Society of Community Nutrition (대한지역사회영양학회)
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Relationships among Serum Adiponectin, Leptin and Vitamin D Concentrations and the Metabolic Syndrome in Farmers

농업인의 혈중 아디포넥틴, 렙틴 및 비타민 D 농도와 대사증후군 간의 관련성

  • Yeon, Seo-Eun (Department of Food and Nutrition, Gangneung-Wonju National University) ;
  • Son, Hee-Ryoung (Department of Food and Nutrition, Gangneung-Wonju National University) ;
  • Choi, Jung-Sook (National Academy of Agricultural Science, Rural Development Administration) ;
  • Kim, Eun-Kyung (Department of Food and Nutrition, Gangneung-Wonju National University)
  • 연서은 (강릉원주대학교 식품영양학과) ;
  • 손희령 (강릉원주대학교 식품영양학과) ;
  • 최정숙 (농촌진흥청 농업과학원) ;
  • 김은경 (강릉원주대학교 식품영양학과)
  • Received : 2014.01.13
  • Accepted : 2014.02.18
  • Published : 2014.02.28
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Abstract

The purpose of this study was to investigate the relationships among serum adiponectin, leptin and vitamin D concentrations and the metabolic syndrome in Korean farmers. 105 (26 males, 79 females) farmers (39~78 years, mean age $59.4{\pm}9.6$ years) in Gangwon - area were included in this study. Anthropometric measurements and biochemical blood analysis of subjects were carried out. The prevalence of obesity, abdominal obesity, hypertension, diabetes, hypertriglyceridemia, hypercholesterolemia and hyper LDL-cholesterolemia, metabolic syndrome were 51.9%, 65.7%, 49.5%, 15.3%, 17.3%, 13.5%, 11.5% and 40.9%, respectively. Serum adiponectin and leptin levels ($8.90{\mu}g/ml$ and 12.6 ng/ml) of females were significantly higher than those ($6.49{\mu}g/ml$ and 4.88 ng/ml) of males. But there was no significant difference in 25(OH)vitamin D concentration between males (15.4 ng/ml) and females (16.9 ng/ml). In the subjects with metabolic syndrome, the adiponectin levels were significantly lower and leptin levels were significantly higher than those of the subjects without metabolic syndrome. Serum adiponectin level had positive correlations with HDL-cholesterol level (r = 0.325, p < 0.001), but showed negative correlations with triglyceride and fasting blood glucose concentrations, body weight and waist/hip circumference ratio (r = -0.202 ~ -0.317, p < 0.05). Serum leptin and 25(OH)vitamin D concentrations were positively correlated with body fat (kg, %) and BMI, waist and hip circumferences (r = 0.244 ~ 0.682, p < 0.001). The results of this study suggested that adiponectin and leptin levels could be credible indices to predict chronic diseases in farmers. However, further research on vitamin D should be carried out considering another factors.

Keywords

References

  1. Adamczak M, Wiecek A, Funahashi T, Chudek J, Kokot F, Matsuzawa Y (2003): Decreased plasma adiponectin concentration in patients with essential hypertension. Am J Hypertens 16(1): 72-75 https://doi.org/10.1016/S0895-7061(02)03197-7
  2. Ahima RS, Flier JS (2000): Adipose tissue as an endocrine organ. Trends Endocrinol Metab 11(8): 327-332 https://doi.org/10.1016/S1043-2760(00)00301-5
  3. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, Hotta K, Shimomura I, Nakamura T, Miyaoka K, Kuriyama H, Nishida M, Yamashita S, Okubo K, Matsubara K, Muraguchi M, Ohmoto Y, Funahashi T, Matsuzawa Y (1999): Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochem Biophys Res Commun 257(1): 79-83 https://doi.org/10.1006/bbrc.1999.0255
  4. Artaza JN, Mehrotra R, Norris KC (2009): Vitamin D and cardiovascular system. Clin J Am Nephrol 4(9): 1515-1522 https://doi.org/10.2215/CJN.02260409
  5. Boden G, Chen X, Kolaczynski JW, Polansky M (1997): Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest 100(5): 1107-1113 https://doi.org/10.1172/JCI119621
  6. Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B (2003): Regulation of adiponectin by adipose tissuederived cytokines: in vivo and in vitro investigations in humans. Am J Physiol Endocrinol Metab 285(3): E527-33 https://doi.org/10.1152/ajpendo.00110.2003
  7. Buettner C, Muse ED, Cheng A, Chen L, Scherer T, Pocai A (2008): Leptin controls adipose tissue lipogenesis via central, STAT3- independent mechanisms. Nat Med 14(6): 667-675 https://doi.org/10.1038/nm1775
  8. Cho YG, Kang JH (2010): Clinical implications of the metabolic syndrome. Food Ind Nutr 15(1): 1-3
  9. Cho YH (2009): Relationnship among Chronic Disease, Health Status and Health Related Lifestyle of Rural elderly by Gender. Korean J Health Educ Promot 26(2): 35-47
  10. Choe JS, Paik HY, Kwon SO (2004): Nutritional status and related factors of residents aged over 50 in longevity areas I. Anthropometric measurements and biochemical nutritional status. Korean J Nutr 37(9): 825-837
  11. Choi KM, Lee J, Lee KW, Seo JA, Oh JH, Kim SG, Kim NH, Choi DS, Baik SH (2004): Serum adiponectin concentrations predict the developments of type 2 diabetes and the metabolic syndrome in elderly Koreans. Clin Endocrinol (Oxf) 61(1): 75-80 https://doi.org/10.1111/j.1365-2265.2004.02063.x
  12. Choi YJ, Chang MJ (2010): Comparison of abdominal fat, Aaipocytokine, metabolic syndrome risk factors between diabetes group and none-diabetes group in individuals with spinal cord injury. Korean J Adapted Physical Activity 18(3): 57-70
  13. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, Retzlaff BM, Knopp RH, Brunzell JD, Kahn SE (2003): Relationship of adiponectin to body fat distribution, Iinsulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 46(4): 459-469
  14. Colston KW (2008): Vitamin D and breast cancer risk. Best Pract Res Clin Endocrinol Metab 22(4): 587-599 https://doi.org/10.1016/j.beem.2008.08.002
  15. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL (1996): Serum immunoreactive - leptin concentrations in normalweight and obese humans. N Engl J Med 334(5): 292-295 https://doi.org/10.1056/NEJM199602013340503
  16. Du Bois D, Du Bois EF (1916): A formula to estimate the approximate surface area if height and weight be known. Arch Int Med 17: 863-871
  17. Editorials (2011): Vitamin D deficiency is not good for you. Diabetes Care 34(5): 1245-1246 https://doi.org/10.2337/dc11-0307
  18. Fasshauer M, Paschke R (2003): Regulation of adipocytokines and insulin resistance. Diabetologia 46(12): 1594-1603 https://doi.org/10.1007/s00125-003-1228-z
  19. Ford ES, Ajani UA, McGuire LC, Liu S (2005): Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care 28(5): 1228-1230 https://doi.org/10.2337/diacare.28.5.1228
  20. Friedewald WT, Levy RI, Fredrickson DS (1972): Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 18: 499-502
  21. Fruhbeck G, Nutr R, Salvador L (2004): Role of adipocytokines in metabolism and disease. Nutr Res 24(10): 803-826 https://doi.org/10.1016/j.nutres.2004.07.002
  22. Gannage-Yared MH, Chedid R, Khalife S, Azzi E, Zoghbi F, Halaby G (2009): Vitamin D in relation to metabolic risk factors, insulin sensitivity and adiponectin in a young middle-eastern population. Eur J Endocrinol 160(6): 965-971 https://doi.org/10.1530/EJE-08-0952
  23. Heo KH, Won YL, Ko KS, Kim KW (2009): Effects of obesity on the physiological levels of adiponectin, leptin and diagnostic indices of metabolic syndrome in male workers. Korean J Occu Health Nurs 18(1): 44-54
  24. Hercberg S, Galan P, Preziosi P, Bertrais S, Mennen L, Malvy D, Roussel AM, Favier A, Briancon S (2004): The SU.VI.MAX Study: A randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med 164(21): 2335-2342 https://doi.org/10.1001/archinte.164.21.2335
  25. Heymsfield SB, McManus CB, Smith J, Stevens V, Nixon DW (1982): Anthropometric measurement of muscle mass, revised equations for calculating bone-free arm muscle area. Am J Clin Nutr 36(4): 680-690
  26. Hjelmesaeth J, Hofso D, Aasheim ET, Jenssen T, Moan J, Hager H, Roislien J, Bollerslev J (2009): Parathyroid hormone, but not vitamin D, is associated with the metabolic syndrome in morbidly obese women and men: a cross-sectional study. Cardiovasc Diabetol 8: 7-2840-8-7 https://doi.org/10.1186/1475-2840-8-7
  27. Holick MF (2007): Vitamin D deficiency. N Engl J Med 357(3): 266-281 https://doi.org/10.1056/NEJMra070553
  28. Hong KP, Kho SH (1992): Diagnosis and drug therapy of hypertension. Diagnosis and drug therapy of hypertension. J Korean Acad Fam Med 13(6): 484-490
  29. Hwang YC, Jee JH, Oh EY, Choi YH, Lee MS, Kim KW, Lee MK (2009): Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes in Koreans. Int J Cardiol 134(3): 313-321 https://doi.org/10.1016/j.ijcard.2008.12.025
  30. Hypponen E, Power C (2006): Vitamin D status and glucose homeostasis in the 1958 British birth cohort: the role of obesity. Diabets Care 29(10): 2244-2246 https://doi.org/10.2337/dc06-0946
  31. JAMA (2001): Executive summary of the third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Adult Tratment Panel 285: 2486-2497
  32. Khader YS, Batieha A, Jaddou H, Batieha Z, El-Khateeb M, Ajlouni K (2011): Relationship between 25-Hydroxyvitamin D and metabolic syndrome among Jordanian adults. Nutr Res Pract 5(2): 132-139 https://doi.org/10.4162/nrp.2011.5.2.132
  33. Kim DL, Kim NH, Shin DH, Kim SG, Choi KM, Kim JK, Shin C, Lee SG (2002): Plasma leptin concentration, obesity, and insulin resistance in healthy Korean population. J Korean Diabetes 26: 100-111
  34. Kim JI, Kang MJ (2012): Recent consumption and physiological status of vitamin D in Korean population. Food Ind Nutr 17(2): 7-10
  35. Kim KJ, Park JS, Ahn NY, Chun WK, Hong CB, Kim EJ, Park SE, Kang SH, Lee SJ (2003): Blood concentrations of lipid profiles and leptin, bone density, and abdominal fat in adult women. J Exerc Nutr Biochem 7(3): 271-276
  36. Kim MJ, Jun HY, RHA HB (2013): Comparison of serum adiponectin levels according to body mass index and dietary behaviors of female university students in Seoul. Korean J Community Nutr 18(4): 354-364 https://doi.org/10.5720/kjcn.2013.18.4.354
  37. Kim MK, Il Kang M, Won Oh K, Kwon HS, Lee JH, Lee WC, Yoon KH, Son HY (2010): The association of serum vitamin D level with presence of metabolic syndrome and hypertension in middle-aged Korean subjects. Clin Endocrinol 73(3): 330-338 https://doi.org/10.1111/j.1365-2265.2010.03798.x
  38. Kim SJ, Park KG, Kim HK, Kim MK, Lee SW, Hwang JS, Han SW, Hur SH, Lee IK (2004): Serum adiponectin concentration according to visceral fat amount and its relationship of metabolic risk factors in premenopausal obese women. Korean J Med 66(3): 259-26
  39. Kim YJ, Moon MS, Yang YJ, Kwon OR (2012): Relationship between serum 25-hydroxyvitamin D concentration and the risks of metabolic syndrome in premenopausal and postmenopausal women. Korean J Nutr 45(1): 20-29 https://doi.org/10.4163/kjn.2012.45.1.20
  40. Koh SB, Park JK, Yoon JH, Chang SJ, Oh SS, Kim JY, Ryu SY, Kim KS, Lee TY, You JS (2010): Preliminary report: A serious link between adiponectin levels and metabolic syndrome in a Korean nondiabetic population. Metabolism 59(3): 333-337 https://doi.org/10.1016/j.metabol.2009.07.031
  41. Kolaczynski JW, Nyce MR, Considine RV, Boden G, Nolan JJ, Henry R, Mudaliar SR, Olefsky J, Caro JF (1996): Acute and chronic effects of insulin on leptin production in humans: studies in vivo and in vitro. Diabetes 45(5): 699-701 https://doi.org/10.2337/diab.45.5.699
  42. Korean National Statistical Office (2012a): Agriculture, Foresty and Fisheries Research Report 2012
  43. Korean National Statistical Office (2012b): The statistics of mortality and the causes. Available from http://www.kostat.go.kr [cited 2013 September 25]
  44. Krakoff J, Funahashi T, Stehouwer CD, Schalkwijk CG, Tanaka S, Matsuzawa Y, Kobes S, Tataranni PA, Hanson RL, Knowler WC, Lindsay RS (2003): Inflammatory markers, adiponectin, and risk of type 2 diabetes in the Pima Indian. Diabetes Care 26(6): 1745-1751 https://doi.org/10.2337/diacare.26.6.1745
  45. Kumada M, Kihara S, Sumitsuji S, Kawamoto T, Matsumoto S, Ouchi N, Arita Y, Okamoto Y, Shimomura I, Hiraoka H, Nakamura T, Funahashi T, Matsuzawa Y (2003): Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol 23(1): 85-89 https://doi.org/10.1161/01.ATV.0000048856.22331.50
  46. Lee EJ, Kim KR, Song YD, Lee HC, Huh KB, Chung CH, Lim SK, Chung YS (1994): Seasonal variation in serum 25-Hydroxyvitamin D in the elderly in Korean. J Kor Soc Endorinol 9(2): 121-127
  47. Lee HC (2007): Estimating optimum level of population in rural areas based on rural population forecasts and over-depopulation classification schemes. Korean J Rural Tourism 14(1): 159-181
  48. Lee HS, Kwun IS, Kwon CS (2008): Anthropometric measurements and biochemical nutritional status of the older residents (50 years and over) in Andong area II. J Korean Soc Food Sci Nutr 37(12): 1599-1608 https://doi.org/10.3746/jkfn.2008.37.12.1599
  49. Lee JH, Hong JH, Kim HJ, Park KS, Lee JM, Kim BJ, Ahn KJ, Jeong BO, Kim SH, Lee SK (2009): A study on the relationship of serum Vitamin D levels with insulin resistance in premenopausal women. J East Asian Soe Dietary Life 19(5): 713-722
  50. Lee MS, Woo MK (2002): A study of health-related habits, dietary behaviors and the health status of the middle-aged and the elderly living in the Chonju Area(II). Korean J Community Nutr 7(6): 749-761
  51. Lee MY, Kim JH (2011): Comparison of serum insulin, leptin, adiponectin and high sensitivity c-reactive protein levels according to body mass index and their associations in adult women. Korean J Community Nutr 16(1): 126-135 https://doi.org/10.5720/kjcn.2011.16.1.126
  52. Lee SE, Moon JH, Ahn JH, Oh YS, Shin SH (2007): The association between plasma adiponectin and the components of metabolic syndrome in adults with abdominal obesity. Korean J Obes 16(4): 147-153
  53. Lim WJ, Yoon JS (1995): A longitudinal study on seasonal variations of physical activity and body composition of rural women. Korean J Nutr 28(9): 893-903
  54. Lindsay RS, Funahashi T, Hanson RL, Matsuzawa Y, Tanaka S, Tataranni PA, Knowler WC, Krakoff J (2002): Adiponectin and development of type 2 diabetes in the Pima Indian population. Lancet 360(9326): 57-58 https://doi.org/10.1016/S0140-6736(02)09335-2
  55. Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G, Ragi-Eis S, Chandler J (2006): The prevalence of Vitamin D inadequacy amongst women with osteoporosis: An international epidemiological investigation. J Intern Med 260(3): 245-254 https://doi.org/10.1111/j.1365-2796.2006.01685.x
  56. Lu L, Yu Z, Pan A, Hu FB, Franco OH, Li H, Li X, Yang X, Chen Y, Lin X (2009): Plasma 25-Hydroxyvitamin D concentration and metabolic syndrome among middle-aged and elderly Chinese individuals. Diabetes Care 32(7): 1278-1283 https://doi.org/10.2337/dc09-0209
  57. Malabanan A, Veronikis IE, Holick MF (1998): Redefining vitamin D insufficiency. Lancet 351(9105): 805-806
  58. Mallamaci F, Zoccali C, Cuzzola F, Tripepi G, Cutrupi S, Parlongo S, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y (2002): Adiponectin in essential hypertension. J Nephrol 15(5): 507-511
  59. Martins D, Wolf M, Pan D, Zadshir A, Tareen NM Thadhani R, Felsenfeld A, Levine B, Mechrotra R, Norris K (2007): Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: data from the Third National Health and Nutrition Examination Survey. Arch Intern Med 167(11): 1159-1165 https://doi.org/10.1001/archinte.167.11.1159
  60. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I (2004): Adiponectin and metabolic syndrome. Arterioscler Thromb Vascboil 24(1): 29-33 https://doi.org/10.1161/01.ATV.0000099786.99623.EF
  61. McKenna MJ (1992): Differences in vitamin D status between countries in young adults and the elderly. AM J Med 93(1): 69-77 https://doi.org/10.1016/0002-9343(92)90682-2
  62. McNeill AM, Rosamond WD, Girman CK, Golden SH, Schmidt ML, East HE (2005): The metabolic syndrome and 11-year risk of incident cardiovascular disease in the atherosclerosis risk in communities Study. Diabtes Care 28(2): 385-390 https://doi.org/10.2337/diacare.28.2.385
  63. Michos ED, Melamed ML (2008): Vitamin D and cardiovascular disease risk. Curr Opin Clin Nutr Metab Care 11: 7-12 https://doi.org/10.1097/MCO.0b013e3282f2f4dd
  64. Ministry of Health and Welfare. Korea Health Statistics 2010 (2011): Korea National Health and Nutrition Examination Survey (KNHANES -1)
  65. Mojiminiyi OA, Abdella NA, Arouj MA, Nakhi AB (2007): Adiponectin, insulin resistance and clinical expression of the metabolic syndrome in patients with type 2 diabetes. Int J Obes 31(2): 213-220 https://doi.org/10.1038/sj.ijo.0803355
  66. Motoshima H, Wu X, Sinha MK, Hardy VE, Rosato EL, Barbot DJ, Rosato FE, Goldstein BJ (2002): Differential regulation of adiponectin secretion from cultured human omental and subcutaneous adipocytes: effects of insulin and rosiglitazone. J Clin Endocrinol Metab 87(12): 5662-5667 https://doi.org/10.1210/jc.2002-020635
  67. Muoio DM, Dohm GL (2002): Peripheral metabolic actions of leptin. Best Pract Res Clin Endocrinol Metab 16(4): 653-666 https://doi.org/10.1053/beem.2002.0223
  68. Nagy TR, Gower BA, Trowbridge CA, Dezenberg C, Shewchuk RM, Goran MI (1997): Effects of gender, ethnicity, body composition, and fat distribution on serum leptin concentrations in children. J Clin Endocrinol Metab 82(7): 2148-2152
  69. NCEP (2001): Third report of the expert panel on detection, evaluation, and treatment of high blood cholesterol in adults
  70. Nishizawa H, Shimomura I, Kishida K, Maeda N, Kuriyama H, Nagaretani H, Matsuda M, Kondo H, Furuyama N, Kihara S, Nakamura T, Tochino Y, Funahashi T, Matsuzawa Y (2002): Androgens decrease plasma adiponectin, an insulin-sensitizing adipocyte-derived protein. Diabetes 51(9): 2734-2741 https://doi.org/10.2337/diabetes.51.9.2734
  71. Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H, Hayakawa N, Suzuki A, Takeda J, Horikawa Y, Itoh M (2008): The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metab Clin Exp 57(2): 268-273 https://doi.org/10.1016/j.metabol.2007.09.011
  72. Oh JY, Hong YS, Sung YA (2003): Association between hyperleptinemia and metabolic syndrome in an urban korean community. J Korean Diabetes Assoc 27(1): 313-322
  73. Ohashi K, Kihara S, Ouchi N, Kumada M, Fujita K, Hiuge A, Hibuse T, Ryo M, Nishizawa H, Maeda N, Maeda K, Shibata R, Walsh K, Funahashi T, Shimomura I (2006): Adiponectin replenishment ameliorates obesity-related hypertension. Hypertension 47(6): 1108-1116 https://doi.org/10.1161/01.HYP.0000222368.43759.a1
  74. Oosterwerff MM, Eekhoff EM, Heymans MW, Lips P, van Schoor NM (2011): Serum 25-hydroxyvitamin D levels and the metabolic syndrome in older persons: a population-based study. Clin Endocrinol (Oxf) 75(5): 608-613 https://doi.org/10.1111/j.1365-2265.2011.04110.x
  75. Paolisso G, Rizzo MR, Mone CM, Tagliamonte MR, Gambardella A, Riondino M, Carella C, Varricchio M, D'Onofrio F (1998): Plasma sex hormones are significantly associated with plasma leptin concentration in healthy subjects. Clin Endocrinol 48(3): 291-297 https://doi.org/10.1046/j.1365-2265.1998.00383.x
  76. Park HA, Kim SY (2013): Recent advance on vitamin D. J Korean Med Assoc 56(4): 310-318 https://doi.org/10.5124/jkma.2013.56.4.310
  77. Park Y (2013): Vitamin D and atopic dermatitis. Allergy Asthma Respir Dis 1(3): 197-202 https://doi.org/10.4168/aard.2013.1.3.197
  78. Reaven GM (1988): Do high carbohydrate diets prevent the development or attenuate the manifestations (or both) of syndrome X? A viewpoint strongly against. Curr Opin Lipidol 8(1): 23-27
  79. Ruige JB, Deckker JM, Blum WF, Stehouwer CD, Nijpels G, Mooy J, Kostense PJ, Bouter LM, Heine RJ (1999): Leptin and variables of body adiposity, energy balance, and insulin resistance in a population-based study. The Hoorn Study. Diabetes Care 22(7): 1097-1104 https://doi.org/10.2337/diacare.22.7.1097
  80. Ryan AS, Berman DM, Nicklas BJ, Sinha M, Gingerich RL, Meneilly GS, Egan JM, Elahi D (2003): Plasma adiponectin and leptin levels, body composition, and glucose utilization in adult women with wide ranges of age and obesity. Diabetes Care 26(8): 2383-2388 https://doi.org/10.2337/diacare.26.8.2383
  81. Ryo M, Nakamura T, Kihara S, Kumada M, Shibazaki S, Takahashi M, Nagaii M, Matsuzawa Y, Funahashi T (2004): Adiponectin as a biomarker of the metabolic syndrome. Circ J 68(11): 975-981 https://doi.org/10.1253/circj.68.975
  82. Ryu ST, Park SO, Kim SH (2005): The relation of serum adiponectin and resistin concentrations with metabolic risk factors. J Korean Soc Endocrinol 20(5): 444-451 https://doi.org/10.3803/jkes.2005.20.5.444
  83. Satoh N, Naruse M, Usui T, Tagami T, Suganami T, Yamada K, Kuzuya H, Shimatsu A, Ogawa Y (2004): Leptin-to-adiponectin ratio as a potential atherogenic index in obese type 2 diabetic patients. Diabetes Care 27(10): 2488-2490 https://doi.org/10.2337/diacare.27.10.2488
  84. Scragg R, Sowers M, Bell C (2007): Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 20(7): 713-719 https://doi.org/10.1016/j.amjhyper.2007.01.017
  85. Segal K, Landt M, Klein S (1996): Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men. Diabetes 45(7): 987-991
  86. Shim WS, Kim HJ, Kang ES, Rhee YM, Ahn CW, Lim SK, Lee HC, Cha BS (2006): The relationship between the leptin concentration and the small dense low density lipoprotein cholesterol concentration in Korean type 2 diabetic patients. J Korean Soc Endocrinol 21(4): 319-327 https://doi.org/10.3803/jkes.2006.21.4.319
  87. Shin MY, Kwun IS (2012): Vitamin D: Is it a vitamin or a hormone? Food Ind Nutr 17(2): 1-6
  88. Suh MK (1995): Health states of the eldery and policy implications. J Korean Geriatr Soc 15(1): 28-39
  89. Tilg H, Monschen AR (2006): Adipocyto-kines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol 6: 772-783 https://doi.org/10.1038/nri1937
  90. Tsou PL, Jiang YD, Chang CC, Wei JN, Sung FC, Lin CC, Chiang CC, Tai TY, Chuang LM (2004): Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care 27(2): 308-313 https://doi.org/10.2337/diacare.27.2.308
  91. Vannamethee SG, Shaper AG, Lennon L, Morris RW (2005): Metabolic syndrome vs Framinham Risk Score for predication of coronary heart disease, stroke, and type 2 diabetes mellitus. Arch Intern Med 165(22): 2644-2650 https://doi.org/10.1001/archinte.165.22.2644
  92. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA (2001): Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86(5): 1930-1935 https://doi.org/10.1210/jcem.86.5.7463
  93. World Health Organization (1998): Obesity. Preventing and managing the global epidemic : Report of a WHO Consultation on Obesity. Geneva
  94. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, Yamashita S, Noda M, Kita S, Ueki K, Eto K, Akanuma Y, Froguel P, Foufelle F, Ferre P, Carling D, Kimura S, Nagai R, Kahn BB, Kadowaki T (2002): Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med 8: 1288-1295 https://doi.org/10.1038/nm788
  95. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, Mori Y, Ide T, Murakami K, Tsuboyama-Kasaoka N, Ezaki O, Akanuma Y, Gavrilova O, Vinson C, Reitman ML, Kagechika H, Shudo K, Yoda M, Nakano Y, Tobe K, Nagai R, Kimura S, Tomita M, Froguel P, Kadowaki T (2001): The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946 https://doi.org/10.1038/90984
  96. Yoo KH, Oh IM, Park JE Kim MJ, Park JS, Park SJ, Jang EJ, Park SW, Kim SJ, Yoon YS, Joung HJ, Baik HW (2012): Metabolic syndrome is associated with low adiponectin level and increased insulin resistance in apparently healthy Koreans. Korean J Obes 21(3): 175-182 https://doi.org/10.7570/kjo.2012.21.3.175
  97. Yoon SJ Lee HS, Lee SW, Tun JE, Kim SY, Cho ER, Lee SJ, Jee EJ, Lee HY, Park JY, Kim HS, Jee SH (2008): The association between adiponectin and diabetes in the Korean population. Metabolism 57: 853-857 https://doi.org/10.1016/j.metabol.2008.01.031
  98. Zhuo Q, Wang Z, Fu P, Piao J, Tian Y, Xu J, Yang X (2009): Comparison of adiponectin, leptin and leptin to adiponectin ratio as diagnostic marker for metabolic syndrome in older adults of Chinese major cities. Diabetes Res Clin Pract 84(1): 27-33 https://doi.org/10.1016/j.diabres.2008.12.019
  99. Zoccali C, Mallamaci F, Tripepi G, Benedetto FA, Cutrupi S, Parlongo S, Malatino LS, Bonanno G, Seminara G, Rapisarda F, Fatuzzo P, Buemi M, Nicocia G, Tanaka S, Ouchi N, Kihara S, Funahashi T, Matsuzawa Y (2002): Adiponectin, metabolic risk factors, and cardiovascular events among patients with end-stage renal disease. J Am Soc Nephrol 13(1): 134-141

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