Journal of Nutrition and Health

  • 제47권1호
  • /
  • Pages.45-50
  • /
  • 2014
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지
DOI QR코드

DOI QR Code

생강 건조 분말의 임신 및 멀미에 의한 오심, 구토 개선 기능성에 대한 체계적 고찰

Systematic review of the effect of dried ginger powder on improvement of nausea and vomiting associated with early pregnancy or motion sickness

  • 곽진숙 (주식회사 바이오푸드씨알오) ;
  • 백주은 (주식회사 바이오푸드씨알오) ;
  • 정세원 (이화여자대학교 바이오푸드네트워크) ;
  • 김주희 (이화여자대학교 바이오푸드네트워크) ;
  • 김지연 (서울과학기술대학교 식품공학과) ;
  • 권오란 (이화여자대학교 바이오푸드네트워크)
  • Kwak, Jin Sook (Biofood CRO Co., Ltd.) ;
  • Paek, Ju Eun (Biofood CRO Co., Ltd.) ;
  • Jeong, Sewon (Biofood Network Center, Ewha Womans University) ;
  • Kim, Joohee (Biofood Network Center, Ewha Womans University) ;
  • Kim, Ji Yeon (Department of Food Science and Technology, Seoul National University of Science and Technology) ;
  • Kwon, Oran (Biofood Network Center, Ewha Womans University)
  • 투고 : 2013.11.19
  • 심사 : 2014.01.06
  • 발행 : 2014.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

생강 건조 분말의 임신 또는 멀미로 인해 발생하는 오심, 구토 개선 기능성을 평가하기 위하여 체계적 고찰을 실시하였다. 2013년 3월 기준으로 DB 검색을 통해 870건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 12건의 연구가 평가되었다. 12건 (2,694명) 중 11건 (2,630명)의 연구에서 통계적으로 유의한 개선 효과 나타났으며 (p < 0.05), 효과를 보이는 일일 섭취량은 0.25~2.5 g이었다. 특히 임신부 대상 연구 9건에서는 모두 유의한 개선 효과를 보였고, 멀미에 대한 효과를 관찰한 3건의 연구 중 1,741명을 대상으로 한 대규모 연구 1건을 포함한 2건에서 구토를 유의하게 개선시키는 것으로 보고되었다. 해당 연구에서 모두 생강섭취로 인한 이상 반응은 없는 것으로 확인되었다.

Purpose: Ginger (Zingiber officinale) has been widely used as an antiemetic agent. This systematic review was aimed at evaluation of the effect of dried ginger powder supplementation on improvement of nausea and vomiting associated with early pregnancy or motion sickness. Methods: We searched Pubmed, Cochrane, Science Direct, and KISS (Korean studies Information Service System) using keywords such as ginger or Zingiber officinale in combination with nausea, vomiting, motion sickness, or pregnancy, published in March 2013. Results: The strength of the evidence was evaluated on the selected 12 RCTs (randomized controlled trials). Eleven trials including 2,630 subjects showed that supplementation with dried ginger powder resulted in significant improvement of nausea or vomiting related to early pregnancy or motion sickness. Among the nine studies including 809 women in early pregnancy before 20 weeks of gestation, ginger supplementation was superior to placebo in five studies (n = 305), and as effective as positive control (vitamin $B_6$ or dimenhydrinate) in four studies (n = 504). Ginger intake significantly reduced the episodes or severity of vomiting related to motion sickness compared to placebo or showed the same effect as several antiemetic drugs in two studies (n = 1,821). Conclusion: Our findings added evidence indicating that ginger powder supplements might improve the symptoms of nausea or vomiting related to early pregnancy or motion sickness without significant adverse events.

키워드

참고문헌

  1. Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 2005; 12(9): 684-701. https://doi.org/10.1016/j.phymed.2004.07.009
  2. National Institutes of Health (US). Dietary Supplement Label Database (DSLD) [Internet]. Bethesda (MA): National Institutes of Health; 2013 Sep [cited 2013 Sep 18]. Available from: http: //www.dsld.nlm.nih.gov/dsld/.
  3. Flake ZA, Scalley RD, Bailey AG. Practical selection of antiemetics. Am Fam Physician 2004; 69(5): 1169-1174.
  4. Yamahara J, Rong HQ, Iwamoto M, Kobayashi G, Matsuda H, Fujimura H. Active components of ginger exhibiting anti-serotonergic action. Phytother Res 1989; 3(2): 70-71. https://doi.org/10.1002/ptr.2650030208
  5. Huang QR, Iwamoto M, Aoki S, Tanaka N, Tajima K, Yamahara J, Takaishi Y, Yoshida M, Tomimatsu T, Tamai Y. Anti-5-hydroxytryptamine3 effect of galanolactone, diterpenoid isolated from ginger. Chem Pharm Bull (Tokyo) 1991; 39(2): 397-399. https://doi.org/10.1248/cpb.39.397
  6. Korea Food & Drug Administration. Guidance for the Evaluation on the Functionality of Health Functional Food. Seoul: Korea Food & Drug Administration; 2008. p.30-32.
  7. U.S. Food and Drug Administration. Guidance for industry: evidence-based review system for the scientific evaluation of health claims [Internet]. Silver Spring (MD): U.S. Food and Drug Administration; 2009 Jan [cited 2013 Nov 15]. Available from: http://www.fda.gov/Food/GuidanceRegulation/GuidanceDocumentsRegulatoryInformation/LabelingNutrition/ucm073332.htm.
  8. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) (IT). Scientific and technical guidance for the preparation and presentation of an application for authorisation of a health claim (revision 1). EFSA J [serial on the Internet]. 2011 [cited 2013 Nov 17]; 9(5): 2170 [about 36 p.]. Available from: http://www.efsa.europa.eu/en/efsajournal/pub/2170.htm.
  9. Jeong S, Kim JY, Paek JE, Kim J, Kwak JS, Kwon O. Systematic review of the effect of omega-3 fatty acids on improvement of blood flow while focused on evaluation of claims for health functional food. J Nutr Health 2013; 46(3): 226-238. https://doi.org/10.4163/jnh.2013.46.3.226
  10. Kim JY, Jeong S, Paek JE, Kim J, Kwak JS, Lee YJ, Kang TS, Kwon O. Systematic review of the effect of coenzyme Q10 on antioxidant capacity while focused on evaluation of claims for health functional food. J Nutr Health 2013; 46(3): 218-225. https://doi.org/10.4163/jnh.2013.46.3.218
  11. Sripramote M, Lekhyananda N. A randomized comparison of ginger and vitamin B6 in the treatment of nausea and vomiting of pregnancy. J Med Assoc Thai 2003; 86(9): 846-853.
  12. Ensiyeh J, Sakineh MA. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial. Midwifery 2009; 25(6): 649-653. https://doi.org/10.1016/j.midw.2007.10.013
  13. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized doubleblind controlled trial. J Med Assoc Thai 2007; 90(1): 15-20.
  14. Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thai 2007; 90(9): 1703-1709.
  15. Vutyavanich T, Kraisarin T, Ruangsri R. Ginger for nausea and vomiting in pregnancy: randomized, double-masked, placebocontrolled trial. Obstet Gynecol 2001; 97(4): 577-582. https://doi.org/10.1016/S0029-7844(00)01228-X
  16. Jackson EA. Is ginger root effective for decreasing the severity of nausea and vomiting in early pregnancy? J Fam Pract 2001; 50(8): 720.
  17. Basirat Z, Moghadamnia A, Kashifard M, Sharifi-Razavi A. The effect of ginger biscuit on nausea and vomiting in early pregnancy. Acta Med Iran 2009; 47(1): 51-56.
  18. Ozgoli G, Goli M, Simbar M. Effects of ginger capsules on pregnancy, nausea, and vomiting. J Altern Complement Med 2009; 15(3): 243-246. https://doi.org/10.1089/acm.2008.0406
  19. Fischer-Rasmussen W, Kjaer SK, Dahl C, Asping U. Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol 1991; 38(1): 19-24. https://doi.org/10.1016/0028-2243(91)90202-V
  20. Weimer K, Schulte J, Maichle A, Muth ER, Scisco JL, Horing B, Enck P, Klosterhalfen S. Effects of ginger and expectations on symptoms of nausea in a balanced placebo design. PLoS One 2012; 7(11): e49031. https://doi.org/10.1371/journal.pone.0049031
  21. Grøntved A, Brask T, Kambskard J, Hentzer E. Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol 1988; 105(1-2): 45-49.
  22. Schmid R, Schick T, Steffen R, Tschopp A, Wilk T. Comparison of seven commonly used agents for prophylaxis of seasickness. J Travel Med 1994; 1(4): 203-206. https://doi.org/10.1111/j.1708-8305.1994.tb00596.x
  23. Regulations on statements made for dietary supplements concerning the effect of the product on the structure or function of the body. Food and Drug Administration, HHS. Final rule. Fed Regist 2000; 65(4): 1000-1050.
  24. Korean Intellectual Property Office. Korean traditional knowledge portal [Internet]. Daejeon: Korean Intellectual Property Office; 2013 [cited 2013 Nov 20]. Available from: http://www.koreantk.com.
  25. Health Canada (CA). Natural health products ingredients database [Internet]. Ottawa: Health Canada; 2013 Nov [cited 2013 Sep 18]. Available from: http://webprod.hc-sc.gc.ca/nhpid-bdipsn/search-rechercheReq.do?lang=eng.

피인용 문헌

  1. Effect of cassia cinnamon intake on improvement of the glycemic response: An updated meta-analysis: Focus on preparation of dehydrated powder and water extract vol.50, pp.5, 2017, https://doi.org/10.4163/jnh.2017.50.5.437
  2. Processed Gingers: Current and Prospective Use in Food, Cosmetic, and Pharmaceutical Industry vol.10, pp.1, 2019, https://doi.org/10.2174/2212798410666180806150142
  3. 역류성 식도염에 대한 반하(半夏), 생강(生薑), 소반하탕(小半夏湯)의 효과 비교 vol.40, pp.2, 2019, https://doi.org/10.13048/jkm.19014
  4. 복합생약 HO-Series의 숙취개선 임상적 유용성 평가 vol.51, pp.4, 2014, https://doi.org/10.22889/kjp.2020.51.4.278