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생강 건조 분말의 임신 및 멀미에 의한 오심, 구토 개선 기능성에 대한 체계적 고찰

Systematic review of the effect of dried ginger powder on improvement of nausea and vomiting associated with early pregnancy or motion sickness

  • 곽진숙 (주식회사 바이오푸드씨알오) ;
  • 백주은 (주식회사 바이오푸드씨알오) ;
  • 정세원 (이화여자대학교 바이오푸드네트워크) ;
  • 김주희 (이화여자대학교 바이오푸드네트워크) ;
  • 김지연 (서울과학기술대학교 식품공학과) ;
  • 권오란 (이화여자대학교 바이오푸드네트워크)
  • Kwak, Jin Sook (Biofood CRO Co., Ltd.) ;
  • Paek, Ju Eun (Biofood CRO Co., Ltd.) ;
  • Jeong, Sewon (Biofood Network Center, Ewha Womans University) ;
  • Kim, Joohee (Biofood Network Center, Ewha Womans University) ;
  • Kim, Ji Yeon (Department of Food Science and Technology, Seoul National University of Science and Technology) ;
  • Kwon, Oran (Biofood Network Center, Ewha Womans University)
  • 투고 : 2013.11.19
  • 심사 : 2014.01.06
  • 발행 : 2014.02.28

초록

생강 건조 분말의 임신 또는 멀미로 인해 발생하는 오심, 구토 개선 기능성을 평가하기 위하여 체계적 고찰을 실시하였다. 2013년 3월 기준으로 DB 검색을 통해 870건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 12건의 연구가 평가되었다. 12건 (2,694명) 중 11건 (2,630명)의 연구에서 통계적으로 유의한 개선 효과 나타났으며 (p < 0.05), 효과를 보이는 일일 섭취량은 0.25~2.5 g이었다. 특히 임신부 대상 연구 9건에서는 모두 유의한 개선 효과를 보였고, 멀미에 대한 효과를 관찰한 3건의 연구 중 1,741명을 대상으로 한 대규모 연구 1건을 포함한 2건에서 구토를 유의하게 개선시키는 것으로 보고되었다. 해당 연구에서 모두 생강섭취로 인한 이상 반응은 없는 것으로 확인되었다.

Purpose: Ginger (Zingiber officinale) has been widely used as an antiemetic agent. This systematic review was aimed at evaluation of the effect of dried ginger powder supplementation on improvement of nausea and vomiting associated with early pregnancy or motion sickness. Methods: We searched Pubmed, Cochrane, Science Direct, and KISS (Korean studies Information Service System) using keywords such as ginger or Zingiber officinale in combination with nausea, vomiting, motion sickness, or pregnancy, published in March 2013. Results: The strength of the evidence was evaluated on the selected 12 RCTs (randomized controlled trials). Eleven trials including 2,630 subjects showed that supplementation with dried ginger powder resulted in significant improvement of nausea or vomiting related to early pregnancy or motion sickness. Among the nine studies including 809 women in early pregnancy before 20 weeks of gestation, ginger supplementation was superior to placebo in five studies (n = 305), and as effective as positive control (vitamin $B_6$ or dimenhydrinate) in four studies (n = 504). Ginger intake significantly reduced the episodes or severity of vomiting related to motion sickness compared to placebo or showed the same effect as several antiemetic drugs in two studies (n = 1,821). Conclusion: Our findings added evidence indicating that ginger powder supplements might improve the symptoms of nausea or vomiting related to early pregnancy or motion sickness without significant adverse events.

키워드

참고문헌

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