Journal of Nutrition and Health

  • 제47권1호
  • /
  • Pages.23-32
  • /
  • 2014
  • /
  • 2288-3886(pISSN)
  • /
  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지
DOI QR코드

DOI QR Code

알쏭이모자반 (Sargassum confusum) 주정추출물이 성인여성 체지방 감소에 미치는 영향

The effect of Sargassum confusum on reduction of body fat in obese women

  • 민기성 (충남대학교 생활과학대학 식품영양학과) ;
  • 한 대석 (한국 식품 연구원 신소재 연구단) ;
  • 권상오 ((주)에스엔디 기업부설연구소) ;
  • 여경목 ((주)에스엔디 기업부설연구소) ;
  • 김복남 (한림성심대학 관광외식조리과) ;
  • 이선영 (충남대학교 생활과학대학 식품영양학과)
  • Min, Ki Sung (Department of Food and Nutrition, Chungnam National University) ;
  • Han, Daeseok (Neo Food Resources Research Group, Korea Food Research Institute) ;
  • Kwon, Sang-Oh (R&D Center, S&D Co., Ltd.) ;
  • Yeo, Kyung-Mok (R&D Center, S&D Co., Ltd.) ;
  • Kim, Bok-Nam (Department of Tourism and Food Service Cuisine, Hallym Polytechnic University) ;
  • Ly, Sun Yung (Department of Food and Nutrition, Chungnam National University)
  • 투고 : 2013.10.01
  • 심사 : 2014.01.23
  • 발행 : 2014.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

해조류인 알쏭이 모자반 추출물의 섭취로 인한 체지방 감소 효능을 평가하고자 이중맹검법을 사용하여 BMI 23 이상의 과체중 혹은 비만 성인 여성에게 8주간 알쏭이 모자반 추출물을 섭취하게 한 후 체격지수, 혈액 분석, 식사섭취상황 등을 조사하였다. 최종 대조군은 14명, 실험군은 16명이었으며 1일3회 각 4개의 캡슐을 섭취시켰다. 인체시험 결과 시험전후 비교시 대조군에 비하여 시험군의 체지방률과 체지방량, 허리둘레가 지속적으로 유의하게 감소하였으며 혈청 트리글리세롤과 렙틴농도가 더욱 유의하게 감소하였고 변배설량은 유의하게 증가하여 지방 배설효과를 기대할 수 있었다. 시험기간 동안 7명의 피험자가 심각하지 않은 부작용으로 시험에서 탈락하였으나 건강상 불편함을 호소하는 피험자 수의 두 군간의 차이는 보이지 않았다. 따라서 알쏭이 모자반 추출물은 8주간 섭취 시 심각한 부작용을 유발하지 않으면서 피험자의 허리둘레, 체지방율과 함께 혈청 렘틴 수치를 유의하게 감소시킬 수 있고 배변횟수를 유의하게 증가시켜 특히 복부비만을 해소할 수 있는 비교적 안전한 기능성 소재로 기대되므로 작용기전을 설명할 수 있는 심층 연구가 필요로 된다.

Purpose: This study was conducted in order to investigate the effect of Sargassum confusum extracts on the reduction of body fat for eight weeks in overweight women ($BMI{\geq_-}23kg/m^2$). Methods: Subjects were classified by double-blind randomized trial as the control group (C group, n = 14) and the Sargassum confusum extract supplementation group (SC group, n = 16), which consumed 12 tablets per day. Questionnaires related to their health status were assessed twice (week 0 and week 8). Their dietary intake status was evaluated by 24-recall method and body compositions were measured using a bioelectrical impedance analyzer. In addition, we assessed the anti-obesity effect and the occurrence possibility of health risk factors during the supplementation periods by hematological and clinical analysis of blood. Results: Waist circumference and body fat (%) were significantly decreased in the SC group. Serum leptin level was also significantly decreased in the SC group. Defecation frequency was significantly increased in the SC group. The above results indicate that Sargassum confusum extract supplementation improves overweight on visceral fat and blood leptin level by increasing bowel movement. These results imply a decrease of health risk factors in overweight women. Seven subjects withdrew from the study due to adverse events; however, no differences regarding adverse events were observed between the control and treatment group. Conclusion: Therefore, Sargassum confusum extract is a plausible effective agent for body fat reduction in humans.

키워드

참고문헌

  1. Garfinkel L. Overweight and cancer. Ann Intern Med 1985; 103 (6 Pt 2): 1034-1036. https://doi.org/10.7326/0003-4819-103-6-1034
  2. Solomon CG, Manson JE. Obesity and mortality: a review of the epidemiologic data. Am J Clin Nutr 1997; 66(4 Suppl): 1044S-1050S. https://doi.org/10.1093/ajcn/66.4.1044S
  3. Moon OR, Kim NS, Jang SM, Yoon TH, Kim SO. Relationship between BMI and prevalence of hypertension & diabetes mellitus based on national health interview survey. J Korean Acad Fam Med 1999; 20(6): 771-786.
  4. Anderson KM, Castelli WP, Levy D. Cholesterol and mortality. 30 years of follow-up from the Framingham study. JAMA 1987; 257(16): 2176-2180. https://doi.org/10.1001/jama.1987.03390160062027
  5. Hill JO, Peters JC. Environmental contributions to the obesity epidemic. Science 1998; 280(5368): 1371-1374. https://doi.org/10.1126/science.280.5368.1371
  6. World Health Organization (CH). Obesity and overweight [Internet]. Geneva: World Health Organization; 2013 Mar [cited 2013 Aug 19]. Available from: http://www.who.int/mediacentre/factsheets/fs311/en/index.html.
  7. Ministry of Health and Welfare, Korea Centers for Disease Control and Prevention. Korea Health Statistics 2009: Korea National Health and Nutrition Examination Survey (KNHANES IV-3) [Internet]. Cheongwon: Korea Centers for Disease Control and Prevention; 2012 Aug [cited2013 Aug 19]. Available from: http://knhanes.cdc.go.kr/.
  8. Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, Styrkarsdottir U, Gretarsdottir S, Thorlacius S, Jonsdottir I, Jonsdottir T, Olafsdottir EJ, Olafsdottir GH, Jonsson T, Jonsson F, Borch-Johnsen K, Hansen T, Andersen G, Jorgensen T, Lauritzen T, Aben KK, Verbeek AL, Roeleveld N, Kampman E, Yanek LR, Becker LC, Tryggvadottir L, Rafnar T, Becker DM, Gulcher J, Kiemeney LA, Pedersen O, Kong A, Thorsteinsdottir U, Stefansson K. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 2009; 41(1): 18-24. https://doi.org/10.1038/ng.274
  9. Escott-Stump S. Malnutrition-obesity and undernutrition. In: Escott-Stump S, editor. Nutrition and Diagnosis-Related Care. New York (NY): Lippincott Williams & Wilkins; 2012. p.609-611.
  10. Bray GA. Medical therapy for obesity. Mt Sinai J Med 2010; 77(5): 407-417. https://doi.org/10.1002/msj.20207
  11. Carter R, Mouralidarane A, Ray S, Soeda J, Oben J. Recent advancements in drug treatment of obesity. Clin Med 2012; 12(5): 456-460. https://doi.org/10.7861/clinmedicine.12-5-456
  12. Ballinger A. Orlistat in the treatment of obesity. Expert Opin Pharmacother 2000; 1(4): 841-847. https://doi.org/10.1517/14656566.1.4.841
  13. Misurcova L, Skrovankova S, Samek D, Ambrozova J, Machu L. Health benefits of algal polysaccharides in human nutrition. Adv Food Nutr Res 2012; 66: 75-145. https://doi.org/10.1016/B978-0-12-394597-6.00003-3
  14. Bocanegra A, Bastida S, Benedu J, Rodenas S, Sanchez-Muniz FJ. Characteristics and nutritional and cardiovascular-health properties of seaweeds. J Med Food 2009; 12(2): 236-258. https://doi.org/10.1089/jmf.2008.0151
  15. Bae SJ. Anticarcinogenic effects of Sargassum fulvellum fractions on several human cancer cell lines in vitro. J Korean Soc Food Sci Nutr 2004; 33(3): 480-486. https://doi.org/10.3746/jkfn.2004.33.3.480
  16. Neyrinck AM, Mouson A, Delzenne NM. Dietary supplementation with laminarin, a fermentable marine beta (1-3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue. Int Immunopharmacol 2007; 7(12): 1497-1506. https://doi.org/10.1016/j.intimp.2007.06.011
  17. Liu QY, Meng QY. In vivo anti-tumor effect of polysaccharide from Sargassum confusum and the mechanisms. Di Yi Jun Yi Da Xue Xue Bao 2004; 24(4): 434-436.
  18. Liu QY, Meng QY. Therapeutic effect of Seaweed Polysaccharide from Sargassum confusum on sarcoma s180 in mice and its mechanism. Ai Zheng 2005; 24(12): 1469-1473.
  19. Liu QY, Meng QY. Effects of Sargassum confusum polysaccharide on the expression of p53 and Rb genes in mouse sarcoma S180 cells. Nan Fang Yi Ke Da Xue Xue Bao 2008; 28(8): 1378-1381.
  20. Kang SH, Cho EK, Choi YJ. $\alpha$Glucosidase inhibitory effects for solvent fractions from methanol extracts of Sargassum fulvellum and its antioxidant and alcohol-metabolizing activities. J Life Sci 2012; 22(10): 1420-1427. https://doi.org/10.5352/JLS.2012.22.10.1420
  21. Kim DS, Park YH. Uronic acid composition, block structure and some related properties of alginic acid (4) On alginic acid from Myagropsis myagroides fensholt and Sargassum horneri C. agardh. Bull Korean Fish Soc 1985; 18(2): 124-130.
  22. Lahaye M. Marine algae as sources of fibres: determination of soluble and insoluble dietary fibre contents in some 'sea vegetables'. J Sci Food Agric 1991; 54(4): 587-594. https://doi.org/10.1002/jsfa.2740540410
  23. Lee EH, Ham J, Ahn HR, Kim MC, Kim CY, Pan CH, Um BH, Jung SH. Inhibitory effects of the compounds isolated from Sargassum yezoense on $\alpha$-glucosidase and oxidative stress. Korean J Pharmacogn 2009: 40(2): 150-154.
  24. Jang YJ, Kwon SO, Yeo KM, Hong MJ, Kim BN, Han D. Antiobesity effect of Sargassum confusum ethanol extract in obese rats. Korean J Food Sci Technol 2011; 43(2); 189-194. https://doi.org/10.9721/KJFST.2011.43.2.189
  25. Korean Society for the Study of Obesity. Guideline for diagonosis and treatment in Asian-pacific areas. Seoul: Korean Society for the Study of Obesity; 2000.
  26. Lee S, Park HS, Kim SM, Kwon HS, Kim DY, Kim DJ, Cho GJ, Han JH, Kim SR, Park CY, Oh SJ, Lee CB, Kim KS, Oh SW, Kim YS, Choi WH, Yoo HJ. Cut-off points of waist circumference for defining abdominal obesity in the Korean population. Korean J Obes 2006; 15(1): 1-9.
  27. Korean Society of Community Nutrition. A questionnaire about dietary life [Internet]. Seoul: Korean Society of Community Nutrition; 2000 [cited2013 Aug 19]. Available from: http://www.dietnet.or.kr/evaluation/evaluation.html.
  28. Brennan AM, Mantzoros CS. Drug Insight: the role of leptin in human physiology and pathophysiology--emerging clinical applications. Nat Clin Pract Endocrinol Metab 2006; 2(6): 318-327. https://doi.org/10.1038/ncpendmet0196
  29. You JS, Park JY, Zhao X, Jeong JS, Choi MJ, Chang KJ. Relationship among serum taurine, serum adipokines, and body composition during 8-week human body weight control program. Adv Exp Med Biol 2013; 776: 113-120. https://doi.org/10.1007/978-1-4614-6093-0_12
  30. Larsson H, Elmstahl S, Berglund G, Ahren B. Evidence for leptin regulation of food intake in humans. J Clin Endocrinol Metab 1998; 83(12): 4382-4385.
  31. Ministry of Food and Drug Safety (KR). Regulation for evaluation on efficacy of health functional food [Internet]. Cheongwon: Ministry of Food and Drug Safety; 2012 [cited 2012 Jun 22]. Available from:http://www.foodnara.go.kr/hfoodi/industry/.
  32. Preuss HG, Rao CV, Garis R, Bramble JD, Ohia SE, Bagchi M, Bagchi D. An overview of the safety and efficacy of a novel, natural (-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med 2004; 35(1-6): 33-48.
  33. Lim IS, Yoon DS, Kim JH, Lim K. The effects of HCA intake and aerobic exercise during 8 weeks on body composition, blood lipid & obesity related hormone in obese women. Korean J Exerc Nutr 2006: 10(3); 185-191.
  34. Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK. Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition 2012; 28(5): 559-565. https://doi.org/10.1016/j.nut.2011.09.008
  35. Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr 2000; 130(12): 2943-2948. https://doi.org/10.1093/jn/130.12.2943
  36. Oda A, Taniguchi T, Yokoyama M. Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 2001; 47(3): 141-150.
  37. Parhami F, Tintut Y, Ballard A, Fogelman AM, Demer LL. Leptin enhances the calcification of vascular cells: artery wall as a target of leptin. Circ Res 2001; 88(9): 954-960. https://doi.org/10.1161/hh0901.090975
  38. Haynes WG, Morgan DA, Walsh SA, Mark AL, Sivitz WI. Receptor-mediated regional sympathetic nerve activation by leptin. J Clin Invest 1997; 100(2): 270-278. https://doi.org/10.1172/JCI119532
  39. Shek EW, Brands MW, Hall JE. Chronic leptin infusion increases arterial pressure. Hypertension 1998; 31(1 Pt 2): 409-414. https://doi.org/10.1161/01.HYP.31.1.409
  40. Konstantinides S, Schafer K, Koschnick S, Loskutoff DJ. Leptindependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest 2001; 108(10): 1533-1540. https://doi.org/10.1172/JCI13143
  41. Padwal R, Li SK, Lau DC. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes Relat Metab Disord 2003; 27(12): 1437-1446. https://doi.org/10.1038/sj.ijo.0802475

피인용 문헌

  1. Effect of Oral Ingestion of Low-Molecular Collagen Peptides Derived from Skate ( Raja Kenojei ) Skin on Body Fat in Overweight Adults: A Randomized, Double-Blind, Placebo-Controlled Trial vol.17, pp.3, 2014, https://doi.org/10.3390/md17030157