한국임상수의학회지 (Journal of Veterinary Clinics)

  • 제31권1호
  • /
  • Pages.66-69
  • /
  • 2014
  • /
  • 1598-298X(pISSN)
  • /
  • 2384-0749(eISSN)
한국임상수의학회 (The Korean Society of Veterinary Clinics)
권호 표지

635 nm Photodynamic Therapy (PDT)를 이용한 개의 난치성 외이염 치료

Photodynamic Therapy Using a 632 nm Diode Laser on Otitis Externa of the Dog

  • Lee, Sug Man (Department of Biomedical Engineering, School of Medicine, Chungnam National University) ;
  • Cho, Eun-Sang (College of Veterinary school, Chungnam National University) ;
  • Lim, Hyun Soo (Department of Biomedical Engineering, School of Medicine, Chungnam National University) ;
  • Kim, Rachel (Gyeongnam National University of Science and Technology) ;
  • Son, Hwa-Young (College of Veterinary school, Chungnam National University)
  • 심사 : 2013.09.26
  • 발행 : 2014.02.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Photodynamic therapy (PDT) is an effective method for infectious disease, but as yet, no clinical trial on otitis externa has been conducted in animals. This report describes 4 cases of PDT treatment on severe otitis externa in canine. Four canines were treated with various concentrations of 5-aminolevulinic acid hydrochloride (5-ALA) and with various J (second ${\times}$ power) and irradiated by light-emitting diode light source at 635 nm, respectively. After the PDT applications, canines incubated in the dark for 5 or 6 hr. All patients showed clinical resolution of otitis externa after PDT treatment at the dose of 0.16~0.3 g ALA and J (54~162 $J/cm^2$). On the basis of these findings, PDT can be considered to be a new therapeutic approach to severe otitis externa in canine.

키워드

참고문헌

  1. Ackroyd R, Kelty C, Brown N, Reed M. The history of photodetection and photodynamic therapy. Photochem Photobiol 2001; 74: 656-669. https://doi.org/10.1562/0031-8655(2001)074<0656:THOPAP>2.0.CO;2
  2. Ahn JC, Shin JI, Chang SY. Antibacterial Effect of Photodynamic Therapy using Photogem and a 632 nm Diode Laser on Helicobacter pylori. J Exp Biomed Sci 2011; 17: 363-366.
  3. Allison RR, Moghissi K. Photodynamic Therapy (PDT): PDT Mechanisms. Clin Endosc 2013; 46: 24-29. https://doi.org/10.5946/ce.2013.46.1.24
  4. Baumgartner R, Huber RM, Schulz HJ, Stepp H, Rick K, Gamarra F, Leberig A, Roth. Inhalation of 5-amonolevulinic acid: a new technique for fluorescence detection of early stage lung cancer. J Photochem Photobiol B 1996; 36: 167-174.
  5. Dougherty TJ, Gomer CJ, Henderson BW, Jori G, Kessel D, Korbelik M, Moan J, Peng Q. Photodynamic therapy. J Natl Cancer Inst 1998; 90: 889-905. https://doi.org/10.1093/jnci/90.12.889
  6. Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, Mittleman A. Photoradiation therapy for the treatment of malignant tumors. Cancer Res 1978; 38: 2628-2635.
  7. Gomer CJ, Rucker N, Ferrario A, Wong S. Properties and applications of photodynamic therapy. Radiat Res 1989; 120: 1-18. https://doi.org/10.2307/3577632
  8. Gotthelf LN. Perpetuating factors and treatment of otitis externa. In: Gotthelf LN. ed. Small Animal Ear Diseases: an Illustrated Guide. St. Louis: Elsevier, 2005: 173-201.
  9. Hopper C. Photodynamic therapy: a clinical reality in the treatment of cancer. Lancet Oncol 2000; 1: 212-219. https://doi.org/10.1016/S1470-2045(00)00166-2
  10. Kato H. History of photodynamic therapy: past, present and future. Gan To Kagaku Ryoho 1996; 23: 8-15.
  11. Kurlenda J, Grinholc M. Alternative therapies in Staphylococcus aureus diseases. Acta Biochim Pol 2012; 59: 171-184.
  12. Lee Y, Baron ED. Photodynamic therapy: current evidence and applications in dermatology. Semin Cutan Med Surg 2011; 30: 199-209. https://doi.org/10.1016/j.sder.2011.08.001
  13. Lim HS. Reduction of thermal damage in photodynamic therapy by laser irradiation techniques. Biomed Opt 2012; 7: 128001.
  14. Murphy KM. A review of techniques for the investigation of otitis externa and otitis media. Clin Tech Small Anim Pract 2001; 16: 236-241. https://doi.org/10.1053/svms.2001.27601
  15. Rosser EJ Jr. Causes of otitis externa. Vet Clin North Am Small Anim Pract 2004; 34: 459-468. https://doi.org/10.1016/j.cvsm.2003.10.006
  16. Saridomichelakis MN, Farmaki R, Leontides LS, Koutinas AF. Aetiology of canine otitis externa: a retrospective study of 100 cases. Vet Dermatol 2007; 18: 341-347. https://doi.org/10.1111/j.1365-3164.2007.00619.x
  17. Sharma SK, Mroz P, Dai T, Huang YY, St Denis TG, Hamblin MR. Photodynamic Therapy for Cancer and for Infections: What Is the Difference? Isr J Chem 2012; 52: 691-705. https://doi.org/10.1002/ijch.201100062
  18. Sharma VD, Rhoades HE. The occurrence and microbiology of otitis externa in the dog. J Small Anim Pract 1975; 16: 241-247. https://doi.org/10.1111/j.1748-5827.1975.tb05740.x
  19. Tan WC, Fulljames C, Stone N, Dix AJ, Shepherd N, Roberts DJ, Brown SB, Krasner N, Barr H. Photodynamic therapy using 5-aminolaevulinic acid for oesophageal adenocarcinoma associated with Barrett's metaplasia. J Photochem Photobiol B 1999; 53: 75-80. https://doi.org/10.1016/S1011-1344(99)00129-3
  20. Trindade FZ, Pavarina AC, Ribeiro AP, Bagnato VS, Vergani CE, Costa CA. Toxicity of photodynamic therapy with LED associated to $Photoge^{\circledR}$ an in vivo study. Lasers Med Sci 2012; 27: 403-411. https://doi.org/10.1007/s10103-011-0909-y
  21. Tuchin VV. Short pulse propagation in tissue. In: Tissue Optics : Light Scattering Methods and Instruments for Medical Diagnosis. 2nd ed. Bellingham: SPIE Press. 2000: 22-27.
  22. Uehlinger P, Zellweger M, Wagnieres G, Juillerat-Jeanneret L, van den Bergh H, Lange N. 5-Aminolevulinic acid and its derivatives: physical chemical properties and protoporphyrin IX formation in cultured cells. J Photochem Photobiol B 2000; 54: 72-80. https://doi.org/10.1016/S1011-1344(99)00159-1