Journal of Yeungnam Medical Science
- Volume 31 Issue 2
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- Pages.75-81
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- 2014
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- 2799-8010(eISSN)
DOI QR Code
Significance of serum total bilirubin as a prognostic factor for hemophagocytic lymphohistiocytosis in childhood
소아에서 발생한 혈구탐식증후군의 예후인자로서 혈청 빌리루빈의 의의
- Yang, Hea Kyoung (Department of Pediatrics, Pusan National University School of Medicine) ;
- Song, Gui Joung (Department of Pediatrics, Pusan National University School of Medicine) ;
- Jun, So Eun (Department of Pediatrics, Pusan National University School of Medicine)
- Received : 2014.05.28
- Accepted : 2014.08.20
- Published : 2014.12.31
Abstract
Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease. Despite of proper treatment and improving treatment regimens, HLH patients still show a fatal prognosis. Therefore the evaluation of prognostic factor is important and there are many studies about hyperbilirubinemia as a prognostic factor in HLH. So we studied the prognostic value of hyperbilirubinemia in HLH children. Methods: A retrospective analysis was performed about 33 patients who were diagnosed with HLH at Pusan National University Hospital and Yangsan Pusan University Hospital between January 2000 to December 2012. We reviewed the clinical characteristics, laboratory findings, and results of treatment to identify hyper-bilirubinemia as a prognostic factor in HLH patients. Results: The median age of patients at diagnosis was 32 months. Most of patients presented with fever, pale appearance, abdominal pain and jaundice. Forty-eight point five percentage of patients showed normal serum bilirubiln level (<2.0 mg/dL) and 51.5% showed hyperbilirubinemia (