Advances in biomechanics and applications

  • 제1권2호
  • /
  • Pages.127-141
  • /
  • 2014
  • /
  • 2287-2094(pISSN)
  • /
  • 2287-2272(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

A preliminary simulation for the development of an implantable pulsatile blood pump

  • Di Paolo, Jose (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios) ;
  • Insfran, Jordan F. (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios) ;
  • Fries, Exequiel R. (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios) ;
  • Campana, Diego M. (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios) ;
  • Berli, Marcelo E. (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios) ;
  • Ubal, Sebastian (Computational Biomechanics Group, Engineering Faculty, National University of Entre Rios)
  • 투고 : 2013.09.24
  • 심사 : 2014.03.03
  • 발행 : 2014.04.25
⟨ 이전 논문 다음 논문 ⟩

초록

A preliminary study of a new pulsatile pump that will work to a frequency greater than 1 Hz, is presented. The fluid-structure interaction between a Newtonian blood flow and a piston drive that moves with periodic speed is simulated. The mechanism is of double effect and has four valves, two at the input flow and two at the output flow; the valves are simulated with specified velocity of closing and reopening. The simulation is made with finite elements software named COMSOL Multiphysics 3.3 to resolve the flow in a preliminary planar configuration. The geometry is 2D to determine areas of high speeds and high shear stresses that can cause hemolysis and platelet aggregation. The opening and closing valves are modelled by solid structure interacting with flow, the rhythmic opening and closing are synchronized with the piston harmonic movement. The boundary conditions at the input and output areas are only normal traction with reference pressure. On the other hand, the fluid structure interactions are manifested due to the non-slip boundary conditions over the piston moving surfaces, moving valve contours and fix pump walls. The non-physiologic frequency pulsatile pump, from the viewpoint of fluid flow analysis, is predicted feasible and with characteristic of low hemolysis and low thrombogenesis, because the stress tension and resident time are smaller than the limit and the vortices are destroyed for the periodic flow.

키워드

과제정보

연구 과제 주관 기관 : National University of Entre Rios

참고문헌

  1. Abe, Y., Saito, I., Isoyama, T., Miura, H., Shi, W., Yamaguchi, S., Inoue, Y., Nakagawa, H., Ono, M., Kishi, A., Ono, T., Kouno, A., Chinzei, T. and Imachi, K. (2008), "A nonpulsatile total artificial heart with 1/R control", J. Artif. Organs, 11(4), 191-200. https://doi.org/10.1007/s10047-008-0434-3
  2. American Heart Association (2002), "Heart and stroke statistical update. Available at http://www.americanheart.org.
  3. Ashrafizaadeh, M. and Bakhshaei, H. (2009), "A comparison of non-Newtonian models for lattice Boltzmann blood flow simulation", Comp. Math. App., 58(5), 1045-1054. https://doi.org/10.1016/j.camwa.2009.02.021
  4. Bethesda, M.D. (1996), "Congestive heart failure in the United States: a new epidemic", National Heart Lung and Blood Institute, National Institutes of Health, September.
  5. Bluestein, D., Chandran, K.B. and Manning K.B. (2010), "Towards non-thrombogenic performance of blood recirculating devices", Ann. Biomed. Eng., 38(3) 1236-1256. https://doi.org/10.1007/s10439-010-9905-9
  6. Goldstein, J.D., Oz, C.M. and Rose, E.A. (1998), "Implantable left ventricular assist devices", New Engl. J. Med., 339, 1522-1533. https://doi.org/10.1056/NEJM199811193392107
  7. Dasi, L.P., Simon, H.A., Sucosky, P. and Yoganathan, A.P. (2009), "Fluid mechanics of artificial heart valves", Clin. Exp. Pharmacol. Physiol., 36(2), 225-237. https://doi.org/10.1111/j.1440-1681.2008.05099.x
  8. Frazier, O.H., Rose, E.A., Oz, M.C., Dembitsky, W., McCarthy, P., Radovancevic, B., Poirier, V.L. and Dasse, K.A. (2001), "Multicenter clinical evaluation of the HeartMate vented electric left ventricular assist system in patients awaiting heart transplantation", J. Thorac. Card. Surg., 122(6), 1186-1195. https://doi.org/10.1067/mtc.2001.118274
  9. Grigioni, M., Daniele, C., Morbiducci, U., D'Avenio, G., Di Benedetto, G. and Barbaro, V. (2004), "The power-law mathematical model for blood damage prediction: analytical developments and physical inconsistencies", Artif. Organs, 28(5), 467-475. https://doi.org/10.1111/j.1525-1594.2004.00015.x
  10. Ismail, Z., Abdullah, I., Mustapha, N. and Amin, N. (2008), "A power law model of blood flow through a tapered overlapping stenosed artery", App. Math. Comp., 195, 669-680. https://doi.org/10.1016/j.amc.2007.05.014
  11. Leverett, L.B., Hellums, J.D., Alfrey, C.P. and Lynch, E.C. (1972), "Red blood cell damage by shear stress", Biophys. J., 12(3), 257-273. https://doi.org/10.1016/S0006-3495(72)86085-5
  12. Malchesky, P.S. (2009), "Artificial organs 2008: a year in review", Artif. Organs, 33(3), 273-295. https://doi.org/10.1111/j.1525-1594.2009.00718.x
  13. Mueller, J., Weng, Y., Dandel, M., Drews, T., Bieda, H., Loebe, M. and Hetzer, R. (2003), "Long-termresults of weaning from LVAD: it does work", ASAIO J., 45(2), 153.
  14. Paul, R., Apel, J., Klaus, S, Schugner, F., Schwindke, P. and Reul, H. (2003), "Shear stress related blooddamage in laminar couette flow", Artif. Organs, 27(6), 517-529. https://doi.org/10.1046/j.1525-1594.2003.07103.x
  15. Robbins, R.C., Kown, M,H., Portner, P.M. and Oyer, P.E. (2001), "The totally implantable Novacor leftventricular assist system", Ann. Thorac. Surg., 1, S162-S165.
  16. Rose, E.A., Gelijns, A.C., Moskowitz, A.J., Heitjan, D.F., Stevenson, L.W., Dembitsky, W., Long, J.W.,Ascheim, D.D., Tierney, A.R., Levitan, R.G., Watson, J.T., Meier, P., Ronan, N.S., Shapiro, P.A., Lazar,R.M., Miller, L.W., Gupta, L., Frazier, O.H., Desvigne-Nickens, P., Oz, M.C. and Poirier, V.L. (2001),"Long-term mechanical left ventricular assistance for end-stage heart failure", N. Engl. J. Med., 345(20),1435-1443. https://doi.org/10.1056/NEJMoa012175
  17. Sallam, A.M., and Hwang, N.H. (1984), "Human red blood cell hemolysis in a turbulent shear flow:contribution of Reynolds shear stresses", Biorheology, 21(6), 783-797. https://doi.org/10.3233/BIR-1984-21605

피인용 문헌

  1. The Impact of Pulsatile Flow on Suspension Force for Hydrodynamically Levitated Blood Pump vol.2019, pp.None, 2014, https://doi.org/10.1155/2019/8065920
  2. Characterization and numerical evaluation of flow and blood damage in a pulsatile left ventricular assist device vol.42, pp.10, 2014, https://doi.org/10.1007/s40430-020-02609-7