Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of feminine cleanser Inclear on sperm motility: A prospective study

  • Park, Dong-Wook (Laboratory of Reproductive Medicine, Cheil General Hospital and Women’s Healthcare Center, Catholic Kwandong University College of Medicine) ;
  • An, Jin Hee (Laboratory of Reproductive Medicine, Cheil General Hospital and Women’s Healthcare Center, Catholic Kwandong University College of Medicine) ;
  • Han, Sang Chul (Laboratory of Reproductive Medicine, Cheil General Hospital and Women’s Healthcare Center, Catholic Kwandong University College of Medicine) ;
  • Lee, Jongwon (WeTTrust Korea Co., Ltd.) ;
  • Lee, Hyo Serk (Department of Urology, Cheil General Hospital and Women's Healthcare Center, Catholic Kwandong University College of Medicine) ;
  • Seo, Ju Tae (Department of Urology, Cheil General Hospital and Women's Healthcare Center, Catholic Kwandong University College of Medicine)
  • Received : 2014.07.25
  • Accepted : 2014.10.23
  • Published : 2014.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The objective of this study is to estimate the effects of Inclear, a feminine cleanser, on sperm motility. Methods: Semen samples were obtained from infertile male patients. Following liquefaction, the raw semen samples were diluted with Ham's F-10 nutrient mixture medium containing 0.4% human serum albumin solution at a ratio of 1:3. The semen samples were subsequently centrifuged to separate the seminal plasma from the serum. The supernatant was discarded, and the pellet was resuspended. The sample was again centrifuged to remove cell debris, and the supernatant was removed. The final pellet was gently loosened by resuspension and incubated in medium alone as a control, and in a 10% solution of the medium plus Inclear. A sampling time of 30 minutes was selected on the basis of sperm transport studies. Sperm motility was evaluated with computer-assisted sperm analysis. Results: A total of 20 samples were analyzed. The mean age of patients was $34.40{\pm}2.96years$. There was no difference in sperm concentration and motility in the two samples at 0 minute and 30 minutes of incubation. In both semen samples, the sperm concentration and motility decreased after an incubation period of 30 minutes. However, there was no statistical difference between the samples. Sperm concentration and motility were not significantly different between the control and Inclear samples after 0 minute and 30 minutes of incubation. Conclusion: Inclear has no negative effects on sperm motility. This product can be recommended to pregnancy planners for vaginal hygiene and as a vaginal lubricant.

Keywords

References

  1. Agarwal A, Deepinder F, Cocuzza M, Short RA, Evenson DP. Effect of vaginal lubricants on sperm motility and chromatin integrity: a prospective comparative study. Fertil Steril 2008;89:375-9. https://doi.org/10.1016/j.fertnstert.2007.02.050
  2. Herbenick D, Reece M, Sanders SA, Dodge B, Ghassemi A, Fortenberry JD. Women's vibrator use in sexual partnerships: results from a nationally representative survey in the United States. J Sex Marital Ther 2010;36:49-65. https://doi.org/10.1080/00926230903375677
  3. Herbenick D, Reece M, Schick V, Sanders SA, Fortenberry JD. Women's use and perceptions of commercial lubricants: prevalence and characteristics in a nationally representative sample of American adults. J Sex Med 2014;11:642-52. https://doi.org/10.1111/jsm.12427
  4. Mowat A, Newton C, Boothroyd C, Demmers K, Fleming S. The effects of vaginal lubricants on sperm function: an in vitro analysis. J Assist Reprod Genet 2014;31:333-9. https://doi.org/10.1007/s10815-013-0168-x
  5. Frishman GN, Luciano AA, Maier DB. Evaluation of Astroglide, a new vaginal lubricant: effects of length of exposure and concentration on sperm motility. Fertil Steril 1992;58:630-2. https://doi.org/10.1016/S0015-0282(16)55279-0
  6. Anderson L, Lewis SE, McClure N. The effects of coital lubricants on sperm motility in vitro. Hum Reprod 1998;13:3351-6. https://doi.org/10.1093/humrep/13.12.3351
  7. Steiner AZ, Long DL, Tanner C, Herring AH. Effect of vaginal lubricants on natural fertility. Obstet Gynecol 2012;120:44-51. https://doi.org/10.1097/AOG.0b013e31825b87ae
  8. Settlage DS, Motoshima M, Tredway DR. Sperm transport from the external cervical os to the fallopian tubes in women: a time and quantitation study. Fertil Steril 1973;24:655-61. https://doi.org/10.1016/S0015-0282(16)39908-3
  9. Hainer BL, Gibson MV. Vaginitis. Am Fam Physician 2011;83:807-15.
  10. Goldenberg RL, White R. The effect of vaginal lubricants on sperm motility in vitro. Fertil Steril 1975;26:872-3. https://doi.org/10.1016/S0015-0282(16)41350-6
  11. Homonnai T, Paz G, Sofer A, Yedwab GA, Kraicer PF. A direct effect of alpha-chlorohydrin on motility and metabolism of ejaculated human spermatozoa. Contraception 1975;12:579-88. https://doi.org/10.1016/0010-7824(75)90019-0
  12. Buch JG, Dikshit RK, Mansuri SM. Effect of certain volatile oils on ejaculated human spermatozoa. Indian J Med Res 1988;87:361-3.
  13. Anderson D. Genetic and reproductive toxicity of butadiene and isoprene. Chem Biol Interact 2001;135-136:65-80. https://doi.org/10.1016/S0009-2797(01)00171-5