Advances in materials Research

  • 제3권4호
  • /
  • Pages.183-197
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  • 2014
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  • 2234-0912(pISSN)
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  • 2234-179X(eISSN)
테크노프레스 (Techno-Press)
권호 표지
DOI QR코드

DOI QR Code

Radiation induced synthesis of (gelatin-co-PVA)-g-poly (AAc) copolymer as wound dressing material

  • Kaur, Inderjeet (Department of Chemistry, Himachal Pradesh University Summer Hill) ;
  • Bhati, Pooja (Department of Chemistry, Himachal Pradesh University Summer Hill) ;
  • Sharma, Sushma (Department of Bio sciences, Himachal Pradesh University Summer Hill)
  • 투고 : 2014.02.28
  • 심사 : 2014.12.16
  • 발행 : 2014.12.25
⟨ 이전 논문 다음 논문 ⟩

초록

Copolymers of gelatin and poly (vinyl alcohol), (PVA) grafted by acrylic acid (AAc) with excellent water absorption and retention abilities under neutral conditions were successfully synthesized using $^{60}Co$ gamma radiations in presence of ammonium persulphate (APS), as water soluble initiator and sodium bicarbonate ($NaHCO_3$) as foaming agent. The optimum synthesis conditions pertaining to maximum swelling percentage were evaluated as a function of gelatin/PVA ratio, amount of water, concentration of APS, $NaHCO_3$, monomer concentration and total irradiation dose. Maximum percent swelling (1694.59%) of the copolymer, gelatin-co-PVA, was obtained at optimum $[APS]=2.92{\times}10^{-1}mol/L$, $[NaHCO_3]=7.94{\times}10^{-2}mol/L$ and 1.5 mL of water at total dose of 31.104 kGy while in case of grafted copolymer, (gelatin-co-PVA)-g-poly(AAc), maximum percent swelling (560.86%) was obtained using $8.014{\times}10^{-1}mol/L$ of AAc in 9 mL water with 31.104 kGy preirradiation dose. The pristine and grafted copolymers were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Scanning electron Microscopy (SEM), Thermal gravimetric analysis (TGA) and X-Ray Diffraction (XRD) methods. The copolymers loaded with an antiseptic, Povidone, were used as wound dressing materials for wounded gastrocnemius muscle of mice and the results exhibit that (gelatin-co-PVA)-g-poly (AAc) copolymer is a potent wound dressing material as compared to the copolymer.

키워드

참고문헌

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피인용 문헌

  1. A Review on Gelatin Based Hydrogels for Medical Textile Applications vol.2020, pp.None, 2020, https://doi.org/10.1155/2020/8866582
  2. Engineered Bioactive Polymeric Surfaces by Radiation Induced Graft Copolymerization: Strategies and Applications vol.13, pp.18, 2014, https://doi.org/10.3390/polym13183102