Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Association of Urinary Cesium with Breast Cancer Risk

  • Qin, Ya-Chao (School of Public Health, Sun Yat-Sen University) ;
  • Tang, Lu-Ying (The Third Affiliated Hospital, Sun Yat-Sen University) ;
  • Su, Yi (School of Public Health, Sun Yat-Sen University) ;
  • Chen, Li-Juan (School of Public Health, Sun Yat-Sen University) ;
  • Su, Feng-Xi (The Second Affiliated Hospital, Sun Yat-Sen University) ;
  • Lin, Ying (The First Affiliated Hospital, Sun Yat-Sen University) ;
  • Zhang, Ai-Hua (Guangdong Prevention and Treatment Center for Occupational Diseases) ;
  • Ren, Ze-Fang (School of Public Health, Sun Yat-Sen University)
  • Published : 2014.12.18
Download PDF
⟨ Previous Next ⟩

Abstract

Background: The aim of this study is to examine the association of urinary cesium with breast cancer risk. Materials and Methods: We collected survey data and urine specimens from 240 women with incident invasive breast cancer before their treatment and 246 age-matched female controls between October 2009 and July 2010. Urinary concentrations of cesium were determined by inductively coupled plasma mass spectrometry. Interviews were conducted by face-to-face to obtain information on potential breast cancer risk factors. Logistic regression analysis was used to estimate the associations. Results: Creatinine-adjusted levels [median ($25^{th}$, $75^{th}$) ug/g] of cesium in cases and controls were 17.6 (13.1, 24.0) and 19.3 (15.3, 25.7), respectively. After adjustment for potential risk factors, women in the second and highest tertile of cesium showed a decreased risk of breast cancer in a dose-dependent manner as compared with those in the lowest tertile [ORs and 95% CIs: 0.75 (0.46-1.22) and 0.50 (0.30-0.82), respectively]. This decrease was more evident in women with ER positive or localized clinical stage in an exploratory stratification analysis. Conclusions: These findings suggest that cesium may have anticancer efficacy and urinary cesium has potential as a biomarker for breast cancer risk assessment.

Keywords

References

  1. Akhter P, Orfi SD, Ahmad N (2003). Caesium concentration in the Pakistani diet. J Environ Radioact, 67, 109-18. https://doi.org/10.1016/S0265-931X(02)00163-7
  2. Arcangeli A, Crociani O, Lastraioli E, et al (2009). Targeting ion channels in cancer: a novel frontier in antineoplastic therapy. Curr Med Chem, 16, 66-93. https://doi.org/10.2174/092986709787002835
  3. Barr DB, Wilder LC, Caudill SP, et al (2005). Urinary creatinine concentrations in the U.S. population: implications for urinary biologic monitoring measurements. Environ Health Perspect, 113, 192-200.
  4. Brewer AK (1984). The high pH therapy for cancer tests on mice and humans. Pharmacol Biochem Behav, 21, 1-5.
  5. Burns JE (1972). Gamma rays: caesium 137 teletherapy units. Br J Radiol, 11, 39-45.
  6. Burrows BA, Cardarelli JA, Sinex FM, et al (1983). The variability in fallout radionuclide distribution: potential radiochemical damage. Trans Am Clin Climatol Assoc, 94, 154-60.
  7. Calloway DR, RD Giaque, Costa F (1974). The superior mineral content of some Amencan Indian food, in comparison to Federal donated counterpart commodities. Ecol Food Nutr, 3, 203-10. https://doi.org/10.1080/03670244.1974.9990382
  8. Cazzaniga M, Decensi A, Bonanni B, et al (2009). Biomarkers for risk assessment and prevention of breast cancer. Curr Cancer Drug Targets, 9, 482-99. https://doi.org/10.2174/156800909788486768
  9. Centers for Disease control and Prevention (CDC) (2014). National center for health statistics (NCHS). national health and nutrition examination survey data (NHANES), 2003-2004. hyattsville, MD: U.S. department of health and human services, centers for disease control and prevention; [accessed 2014 Aug 1]. Available from: http://www.cdc.gov/nchs/.
  10. Cui Y, Shu X-O, Gao Y, et al (2004). Use of complementary and alternative medicine by Chinese women with breast cancer. Breast Cancer Res Treat, 85, 263-70. https://doi.org/10.1023/B:BREA.0000025422.26148.8d
  11. El-Domeiri AA, Messiha FS, Hsia WC (1981). Effect of alkali metal salts on Sarcoma I in A/J mice. J Surg Oncol, 18, 423-9. https://doi.org/10.1002/jso.2930180410
  12. Fan L, Strasser-Weippl K, Li JJ, et al (2014). Breast cancer in China. Lancet Oncol, 15, 279-89. https://doi.org/10.1016/S1470-2045(13)70567-9
  13. Fort M, Cosin-Tomas M, Grimalt JO, et al (2014). Assessment of exposure to trace metals in a cohort of pregnant women from an urban center by urine analysis in the first and third trimesters of pregnancy. Environ Sci Pollut Res Int, 21, 9234-41. https://doi.org/10.1007/s11356-014-2827-6
  14. Ghosh A, Sharma A, Talukder G (1993). Effects of cesium on cellular systems. Biol Trace Elem Res, 38, 165-203. https://doi.org/10.1007/BF02784052
  15. Guns ES, Xie X, Fedoruk M, et al (2005). pH modulation using CsCl enhances therapeutic effects of vitamin D in LNCaP tumor bearing mice. Prostate, 64, 316-22. https://doi.org/10.1002/pros.20257
  16. Kuhnlein HV, Chan HM (2000). Environment and contaminants in traditional food systems of northern indigenous peoples. Annu Rev Nutr, 20, 595-626. https://doi.org/10.1146/annurev.nutr.20.1.595
  17. Lang F, Foller M, Lang KS, et al (2005). Ion channels in cell proliferation and apoptotic cell death. J Membr Biol, 205, 147-57. https://doi.org/10.1007/s00232-005-0780-5
  18. Lin Y, Shao N, Zhang YJ, et al (2012). Risk assessment of breast cancer in Guangdong, China: a community-based survey. Asian Pac J Cancer Prev, 13, 2759-63. https://doi.org/10.7314/APJCP.2012.13.6.2759
  19. Liu J, Yang XL, Li A, et al (2014). Epidemiological patterns of cancer incidence in southern China: based on 6 populationbased cancer registries. Asian Pac J Cancer Prev, 15, 1471-5. https://doi.org/10.7314/APJCP.2014.15.3.1471
  20. Low JC, Wasan KM, Fazli L, et al (2007). Assessing the therapeutic and toxicological effects of cesium chloride following administration to nude mice bearing PC-3 or LNCaP prostate cancer xenografts. Cancer Chemother Pharmacol, 60, 821-9. https://doi.org/10.1007/s00280-007-0429-4
  21. Lyon AW, Mayhew WJ (2003). Cesium toxicity: a case of self-treatment by alternate therapy gone awry. Ther Drug Monit, 25, 114-6. https://doi.org/10.1097/00007691-200302000-00018
  22. McCracken M, Olsen M, Chen MS, Jr., et al (2007). Cancer incidence, mortality, and associated risk factors among Asian Americans of Chinese, Filipino, Vietnamese, Korean, and Japanese ethnicities. CA Cancer J Clin, 57, 190-205. https://doi.org/10.3322/canjclin.57.4.190
  23. Paschal DC, Ting BG, Morrow JC, et al (1998). Trace metals in urine of United States residents: reference range concentrations. Environ Res, 76, 53-9. https://doi.org/10.1006/enrs.1997.3793
  24. Rundo J (1964). The metabolism of biologically important radionuclides. Vi. a survey of the metabolism of caesium in man. Br J Radiol, 37, 108-14. https://doi.org/10.1259/0007-1285-37-434-108
  25. Sartori HE (1984). Cesium therapy in cancer patients. Pharmacol Biochem Behav, 21, 11-3. https://doi.org/10.1016/0091-3057(84)90154-0
  26. Su Y, Chen LJ, He JR, et al (2011). Urinary rubidium in breast cancers. Clin Chim Acta, 412, 2305-9. https://doi.org/10.1016/j.cca.2011.08.035
  27. Tufte FW, Tufte MJ (1984). The effects of zinc gluconate, vitamin A and caesium salts on colon carcinoma in mice. Cytobios, 39, 177-82.
  28. Wacholder S, Chatterjee N, Hartge P (2002). Joint effect of genes and environment distorted by selection biases. Cancer Epidemiol Biomarkers Prev, 11, 885-9.
  29. Wacholder S, Silverman DT, McLaughlin JK, et al (1992). Selection of controls in case-control studies. II. Types of controls. Am J Epidemiol, 135, 1029-41.
  30. Wang J, Chen R, Zhu H (2002). Study in China on ingestion and organ content of trace elements of importance in radiological protection. Food Nutr Bull, 23, 217-21.
  31. Wasserman LR, Glass JL (1968). Therapy with radioisotopes: a general survey (excluding iodine). J Mt Sinai Hosp N Y, 35, 68-85.
  32. Weiger TM, Colombatto S, Kainz V, et al (2007). Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism. Biochem Soc Trans, 35, 391-5. https://doi.org/10.1042/BST0350391
  33. Wonderlin WF, Strobl JS (1996). Potassium channels, proliferation and G1 progression. J Membr Biol, 154, 91-107. https://doi.org/10.1007/s002329900135