Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prognostic Value of PLCE1 Expression in Upper Gastrointestinal Cancer: a Systematic Review and Meta-analysis

  • Cui, Xiao-Bin (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Peng, Hao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Su (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Ting-Ting (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Liu, Chun-Xia (Department of Pathology and Key Laboratory for Xinjiang Endemic and Ethnic Diseases, Shihezi University School of Medicine) ;
  • Zhang, Shu-Mao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Jin, Ting-Ting (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Hu, Jian-Ming (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Jiang, Jin-Fang (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Liang, Wei-Hua (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Na (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Li (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Chen, Yun-Zhao (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology) ;
  • Li, Feng (Department of Oncology, Tongji Hospital, Huazhong University of Science and Technology)
  • Published : 2014.12.18
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Abstract

Background: A number of studies have identified a shared susceptibility locus in phospholipase C epsilon 1 (PLCE1) for esophageal squamous cell carcinoma (ESCC) and gastric cardia adenocarcinomas (GCA). However, the results of PLCE1 expression in esophageal and gastric cancer remain inconsistent and controversial. Moreover, the effects on clinicopathological features remain undetermined. This study aimed to provide a precise quantification of the association between PLCE1 expression and the risk of ESCC and GCA through meta-analysis. Materials and Methods: Eligible studies were identified from PubMed, Wanfang Data, ISI Web of Science, and the Chinese National Knowledge Infrastructure databases. Using RevMan5.2 software, pooled odds ratios (ORs) with 95% confidence intervals (CIs) were employed to assess the association of PLCE1 expression with clinicopathological features relative to ESCC or GCA. Results: Seven articles were identified, including 761 esophageal and gastric cancer cases and 457 controls. Overall, we determined that PLCE1 expression was associated with tumor progression in both esophageal cancers (pooled OR=5.93; 95%CI=3.86 to 9.11) and gastric cancers (pooled OR=9.73; 95%CI=6.46 to 14.7). Moreover, invasion depth (pooled OR=3.62; 95%CI=2.30 to 5.70) and lymph node metastasis (pooled OR=4.21; 95%CI=2.69 to 6.59) were linked with PLCE1 expression in gastric cancer. However, no significant associations were determined between PLCE1 overexpression and the histologic grade, invasion depth, and lymph node metastasis in esophageal cancer. Conclusions: Our metaanalysis results indicated that upregulated PLCE1 is significantly associated with an increased risk of tumor progression in ESCC and GCA. Therefore, PLCE1 expression can be appropriately regarded as a promising biomarker for ESCC and GCA patients.

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References

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