Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Lack of Prognostic Value of Human Epidermal Growth Factor- Like Receptor 2 Status in Inflammatory Breast Cancer (IBC): a Meta-analysis

  • Li, Xiu-Juan (Department of General Surgery, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University) ;
  • Zha, Quan-Bin (Department of Oncology, Jintan Hospital Affiliated to Jiangsu University) ;
  • Xu, Xin-Yu (Department of Pathology, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University) ;
  • Xia, Lei (Department of Pathology, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University) ;
  • Zhang, Zhe (Department of Pathology, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University) ;
  • Ren, Zhao-Jun (Department of Pathology, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University) ;
  • Tang, Jin-Hai (Department of General Surgery, Jiangsu Cancer Hospital, The Affiliated Hospital of Nanjing Medical University)
  • Published : 2014.12.18
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Abstract

Inflammatory breast cancer (IBC) is a rare, aggressive form of breast cancer which is more likely to be her-2/neu amplified. While the her-2/neu status has been utilised to predict prognosis, the published data are inconsistent. The present meta-analysis was conducted to determine whether the her-2/neu status predicts outcomes. Papers were selected from the PubMed database based on defined inclusion and exclusion criteria. Parameters such as total patients, follow-up time and outcome statistics (i.e. overall survival (OS), relapse-free survival (RFS) were collected. The analysis included 6 studies with 2,838 IBC patients. The summary hazards ratio (HR) estimating the association of OS with HER-2-positive disease was 0.96 (95% confidence interval (95%CI: 0.85-1.10)), with similar findings for RFS (HR=0.81, 95%CI: 0.61-1.09). No obvious statistical heterogeneity was detected. This meta-analysis suggests that HER-2-positive status is not an independent adverse prognostic factor for survival among IBC patient cases.

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References

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