Polymer(Korea) (폴리머)

The Polymer Society of Korea (한국고분자학회)
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Radiation Synthesis and Anti-inflammatory Evaluation of Polysaccharide Hydrogels from Ulmus Davidiana Var. Japonica

방사선을 이용한 느릅나무 추출 다당류가 함유된 하이드로젤의 제조 및 항염증성 평가

  • Gwon, Hui-Jeong (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Park, Eun Ji (Quegenbiotech, Co., Ltd.) ;
  • Choi, Jong-Bae (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Lim, Jong-Young (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Jeong, Jin-Oh (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Shin, Young-Min (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Jeong, Sung In (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Park, Jong-Seok (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Lim, Youn-Mook (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Choi, Young-Hun (Citrus Research Station, Rural Development Administration) ;
  • Kim, Sang-Suk (Citrus Research Station, Rural Development Administration)
  • 권희정 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 박은지 ((주)큐젠바이오텍) ;
  • 최종배 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 임종영 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 정진오 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 신영민 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 정성린 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 박종석 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 임윤묵 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 최영훈 (농촌진흥청 국립원예특작과학원) ;
  • 김상숙 (농촌진흥청 국립원예특작과학원)
  • Received : 2013.08.26
  • Accepted : 2013.10.17
  • Published : 2014.01.25
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Abstract

In this study, polysaccharide-poly(vinyl alcohol) (PVA) hydrogels were prepared by using ${\gamma}$-ray and evaluated for potential application as an anti-inflammation patch. Ulmus davidiana var. japonica (UD), one of polysaccharides has been particularly used as an oriental remedy for the treatment of inflammation and ulcers. PVA as a biocompatible polymer and glycerin as a moisturizer were blended with the UD, and its hydrogels were prepared by radiation crosslinking. Characterizations for UD hydrogels were performed by using cytotoxicity assay, antioxidant activity test, and physicochemical test such as gel fraction ratio, and swelling behavior. The results showed that these UD hydrogels had excellent physical properties, anti-inflammation activity, and non-cytotoxicity on the cells. Therefore, these polysaccharide based-UD hydrogels can be effectively used as an inflammation patch.

본 연구에서는 방사선 기술을 이용하여 항염증 특성을 가지는 천연 추출물을 함유하는 고분자 하이드로젤을 제조하여 항염증 패치로서의 유용성을 확인하였다. 천연 추출물로는 오래 전부터 전통 민간요법으로 항염제나 궤양 및 종양 치료 등에 사용되고 있는 느릅나무를 사용하였고, 생체 적합성 고분자인 poly(vinyl alcohol)(PVA)와 보습률 향상을 위해 글리세린을 첨가하여 감마선 가교에 의해 다당류 함유 고분자 하이드로젤을 제조하였다. 제조된 하이드로젤은 항염증 패치로 사용하기에 우수한 기계적 물성을 나타내었고, 사이토카인 분비를 효과적으로 억제함은 물론 세포독성도 나타나지 않는 것을 확인하였다. 결론적으로 느릅나무 추출 다당류가 함유된 하이드로젤은 항염증 패치로써 유용하게 사용될 수 있음을 확인하였다.

Keywords

Acknowledgement

Supported by : 교육과학기술부

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