Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Expression of Beta-catenin-interacting Protein 1 (CTNNBIP1) Gene Is Increased under Hypothermia but Decreased under Additional Ischemia Conditions

  • Kwon, Kisang (Department of Biomedical Laboratory Science, College of Health & Welfare, Kyungwoon University) ;
  • Kim, Seung-Whan (Department of Emergency Medicine, Chungnam National University) ;
  • Yu, Kweon (Korea Research Institute of Bioscience & Biotechnology) ;
  • Kwon, O-Yu (Department of Anatomy, College of Medicine, Chungnam National University)
  • Received : 2014.07.16
  • Accepted : 2014.08.07
  • Published : 2014.09.30
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Abstract

It has recently been shown that hypothermia treatment improves brain ischemia injury and is being increasingly considered by many clinicians. However, the precise roles of hypothermia for brain ischemia are not yet clear. In the present study we demonstrated firstly that hypothermia induced beta-catenin-interacting protein 1 (CTNNBIP1) gene expression and its expression was dramatically decreased under ischemic conditions. It was also demonstrated that hypothermia activated endoplasmic reticulum (ER) stress sensors especially both, the phosphorylation of $eIF2{\alpha}$, and ATF6 proteolytic cleavage. However, the factors of apoptosis and autophagy were not associated with hypothermia. These findings suggested that hypothermia controlled CTNNBIP1 gene expression under ischemia, which may provide a clue to the development of treatments and diagnostic methods for brain ischemia.

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References

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