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Bee Venom Pharmacopuncture: An Effective Treatment for Complex Regional Pain Syndrome

  • Kim, Jong-Min (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Jeon, Hyung-Joon (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Kim, Hyun-Ji (Department of Acupuncture and Moxibustion, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Cho, Chong-Kwan (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East West Cancer Center, Dunsan Korean Medicine Hospital of Daejeon University)
  • Received : 2014.08.20
  • Accepted : 2014.09.01
  • Published : 2014.12.30

Abstract

Objectives: Treating complex regional pain syndrome (CRPS) is difficult because it still does not have a recommended therapy. A 29-year-old man was diagnosed with CRPS after surgery on his $4^{th}$ and $5^{th}$ left toes 7 years ago. Though he had undergone diverse pain treatment, the symptoms persisted, so he visited Dunsan Korean Medicine Hospital of Daejeon University. This case report presents results on the effect of bee venom pharmacopuncture in treating patient with CRPS. Methods: Bee venom pharmacopuncture (BVP), 0.15 to 0.4 mL dosage, was administered at GB43. The treatment was applied each week for a total 14 times. The symptoms were evaluated using a numeric rating scale (NRS) and the dosage of pain medicine. Results: On the first visit, he was taking an anticonvulsant, a trycyclic antidepressant, and an analgesic. On the NRS the worst pain in the toes received a score of 8. He also complained of severe pain and hypersensitivity when the $4^{th}$ and the $5^{th}$ toes were touched just slightly. Other complaint included dyspepsia, rash, and depression. After treatment, on the NRS, the score for toe pain was 0, and he no longer needed to take pain medication. During the 4-months follow-up period, he has remained without pain; neither have additional symptoms appeared nor adverse events occurred. Conclusion: BVP may have potential benefits for treating patients with CRPS.

Keywords

References

  1. Harden RN, Oaklander AL, Burton AW, Perez RS, Richardson K, Swan M, et al. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med. 2013;14(2):180-229. https://doi.org/10.1111/pme.12033
  2. Harden RN, Bruehl S, Stanton-Hicks M, Wilson PR. Proposed new diagnostic criteria for complex regional pain syndrome. Pain Med. 2007;8(4):326-31. https://doi.org/10.1111/j.1526-4637.2006.00169.x
  3. Rowbotham MC. Pharmacologic management of complex regional pain syndrome. Clin J Pain. 2006;22(5):425-9. https://doi.org/10.1097/01.ajp.0000194281.74379.01
  4. Van Buyten JP, Smet I, Liem L, Russo M, Huygen F. Stimulation of dorsal root ganglia for the management of complex regional pain syndrome: a prospective case series. Pain Pract. 2014;12170.
  5. Borchers AT, Gershwin ME. Complex regional pain syndrome: a comprehensive and critical review. Autoimmun Rev. 2014;13(3):242-65. https://doi.org/10.1016/j.autrev.2013.10.006
  6. Hommer DH. Chinese scalp acupuncture relieves pain and restores function in complex regional pain syndrome. Mil Med. 2012;177(10):1231-4. https://doi.org/10.7205/MILMED-D-12-00193
  7. Sprague M, Chang JC. Integrative approach focusing on acupuncture in the treatment of chronic complex regional pain syndrome. J Altern Complement Med. 2011;17(1):67-70. https://doi.org/10.1089/acm.2010.0088
  8. Lee EJ, Yoon IJ. [The clinical observation of 1 case of the complex regional pain syndrome]. J of the Institute of Orient Med of Daejeon Univ. 2009;18(1):109-16. Korean.
  9. Chung JH, Yun YU, Cheong SH, Kim SW, Choi HS, Shin DJ, et al. [The clinical observation of 1 case of type 1 complex regional pain syndrome treated with korean medicine treatment and harpagophytum radix pharmacopuncture]. The Journal of Korea CHUNA Manual Medicine for spine & nerves. 2013;8(1):63-73. Korean.
  10. Cho TH, Park KM. [Effect of placental extract on immobilization of shoulder joint in a complex regional pain syndrome patient]. The Acupuncture. 2012;29(4):93-7. Korean.
  11. Tran de QH, Duong S, Bertini P, Finlayson RJ. Treatment of complex regional pain syndrome: a review of the evidence. Can J Anaesth. 2010;57(2):149-66. https://doi.org/10.1007/s12630-009-9237-0
  12. Shibuya N, Humphers JM, Agarwal MR, Jupiter DC. Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery: systematic review and meta-analysis. J Foot Ankle Surg. 2013;52(1):62-6. https://doi.org/10.1053/j.jfas.2012.08.003
  13. Roh DH, Kwon YB, Kim HW, Ham TW, Yoon SY, Kang SY, et al. Acupoint stimulation with diluted bee venom (apipuncture) alleviates thermal hyperalgesia in a rodent neuropathic pain model: involvement of spinal alpha 2-adrenoceptors. J Pain. 2004;5(6):297-303. https://doi.org/10.1016/j.jpain.2004.05.003
  14. Lim BS, Moon HJ, Li DX, Gil M, Min JK, Lee G, et al. Effect of bee venom acupuncture on oxaliplatin-induced cold allodynia in rats. Evid Based Complement Alternat Med. 2013;369324.
  15. Park JW, Jeon JH, Yoon JW, Jung TY, Kwon KR, Cho CK, et al. Effects of sweet bee venom pharmacopuncture treatment for chemotherapy-induced peripheral neuropathy: a case series. Integr Cancer Ther. 2012;11(2):166-71. https://doi.org/10.1177/1534735411413265
  16. Yoon JW, Jeon JH, Lee YW, Cho CK, Kwon KR, Shin JE, et al. Sweet bee venom pharmacopuncture for chemotherapy-induced peripheral neuropathy. J Acupunct Meridian Stud. 2012;5(4):156-65. https://doi.org/10.1016/j.jams.2012.05.003

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