Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
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In-vitro Anti-thrombosis Activity of Sphagnum palustre

수태의 항혈전 활성

  • Lee, Ye-Seul (Department of Food and Nutrition, Andong National University) ;
  • Jung, Su-Jin (Department of Food and Nutrition, Andong National University) ;
  • Kim, Mi-Sun (Department of Food and Nutrition, Andong National University) ;
  • Sohn, Ho-Yong (Department of Food and Nutrition, Andong National University) ;
  • Jung, In-Chang (Department of Food and Nutrition, Andong National University)
  • 이예슬 (안동대학교 식품영양학과) ;
  • 정수진 (안동대학교 식품영양학과) ;
  • 김미선 (안동대학교 식품영양학과) ;
  • 손호용 (안동대학교 식품영양학과) ;
  • 정인창 (안동대학교 식품영양학과)
  • Received : 2014.09.24
  • Accepted : 2014.11.06
  • Published : 2014.12.28
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Abstract

Sphagnum palustre (SP), a species of moss belong to the Sphagnaceae family, is used as a dwarfed potted plant, in diapers, bandages, and soil additives. Although, SP can be found all over the world and is very cheap, the study of SP components and bioactivities are still at a rudimentary stage. In this study, the hot-water extract of SP (HWSP) and its subsequent organic solvent fractions were prepared, and their in-vitro anti-thrombosis activities were evaluated. The results showed that the water residue of HWSP has a strong anti-coagulation activity with significant extensions of thrombin time, and platelet aggregation activity. Our results suggest that the SP has the potential to be a novel resource for anti-thrombosis agents. This report provides the first evidence of the anti-thrombosis activity of SP.

수태(Sphagnum palustre)는 물이끼과(Sphagnaceae)의 연한 녹색 선태식물로 분재, 기저귀, 수술용 붕대, 토양 첨가제 등으로 이용된다. 지구상의 거의 모든 곳에서 생육하며 매우 저렴하게 생산되지만, 이의 성분 및 생리활성에 대한 연구는 미미한 실정이다. 본 연구에서는 수태의 열수 추출물과 이의 순차적 유기용매 분획물을 조제한 후 혈액응고 저해활성과 혈소판 응집저해를 평가한 결과, 열수 추출물의 물 잔류물에서 강력한 혈액응고 저해활성과 혈소판 응집 촉진 활성을 동시에 확인하였다. 본 연구결과는 수태가 항혈전제로 개발 가능함을 제시하며, 이는 수태의 항혈전 활성에 대한 최초의 보고이다.

Keywords

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