References
- Levy D, Zochodne DW. Local nitric oxide synthase activity in a model of neuropathic pain. Eur J Neurosci. 1998;10:1846-1855. https://doi.org/10.1046/j.1460-9568.1998.00186.x
- Khalil Z, Khodr B. A role for free radicals and nitric oxide in delayed recovery in aged rats with chronic constriction nerve injury. Free Rad Biol Me. 2001;31:430-439. https://doi.org/10.1016/S0891-5849(01)00597-4
- Liu D, Liu J, Sun D, Wen J. The time course of hydroxyl radical formation following spinal cord injury: the possible role of the iron-catalyzed Haber-Weiss reaction. J Neurotrauma. 2004;21:805-816. https://doi.org/10.1089/0897715041269650
- Wang ZQ, Porreca F, Cuzzocrea S, Galen K, Lightfoot R, Masini E. A newly identified role for superoxide in inflammatory pain. J Pharmacol Exp Ther. 2004;309:869-878. https://doi.org/10.1124/jpet.103.064154
- Gonzalez C, Sanz-Alfayate G, Agapito MT, Gomez-Nino A, Rocher A, Obeso A. Significance of ROS in oxygen sensing in cell systems with sensitivity to physiological hypoxia. Respir Physiol Neurobiol. 2002;132:17-41. https://doi.org/10.1016/S1569-9048(02)00047-2
- Baran CP, Zeigler MM, Tridandapani S, Marsh CB. The role of ROS and RNA in regulating life and death of blood monocytes. Curr Pharm. 2004;10:855-866. https://doi.org/10.2174/1381612043452866
- Bubici C, Papa S, Pham CG, Zazzeroni F, Franzoso G. The NF-kappaB-mediated control of ROS and JNK signaling. Histol Histopathol. 2006;21:69-80.
- Zorov DB, Juhaszova M, Sollott SJ. Mitochondrial ROS-induced ROS release: an update and review. Biochim Biophys Acta. 2006;1757:509-517. https://doi.org/10.1016/j.bbabio.2006.04.029
- Kim HY, Chung JM, Chung K. Increased production of mitochondrial superoxide in the spinal cord induces pain behaviors in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci Lett. 2008;447:87-91. https://doi.org/10.1016/j.neulet.2008.09.041
- Watt BE, Proudfoot AT, Vale JA. Hydrogen peroxide poisoning. Toxicol. Rev. 2004;23:51-57. https://doi.org/10.2165/00139709-200423010-00006
- Kim HK, Park SK, Zhou JL, Taglialatela G, Chung K, Coggeshall RE, Chung JM. Reactive oxygen species (ROS) play an important role in a rat model of neuropathic pain. Pain. 2004;111:116-124. https://doi.org/10.1016/j.pain.2004.06.008
- Park ES, Gao X, Chung JM, Chung K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci Lett. 2006;391:108-111. https://doi.org/10.1016/j.neulet.2005.08.055
- Schwartz ES, Kim HY, Wang J, Lee I, Klann E, Chung JM, Chung K. Persistent pain is dependent on spinal mitochondrial antioxidant levels. J Neurosci. 2009;29:159-168, https://doi.org/10.1523/JNEUROSCI.3792-08.2009
- Guan Y, Yaster M, Raja SN, Tao YX. Genetic knockout and pharmacologic inhibition of neuronal nitric oxide synthase attenuate nerve injury-induced mechanical hypersensitivity in mice. Mol Pain. 2007;3:29. https://doi.org/10.1186/1744-8069-3-29
- Tanabe M, Nagatani Y, Saitoh K, Takasu K, Ono H. Pharmacological assessments of nitric oxide synthase isoforms and downstream diversity of NO signaling in the maintenance of thermal and mechanical hypersensitivity after peripheral nerve injury in mice. Neuropharmacology. 2009;56:702-708. https://doi.org/10.1016/j.neuropharm.2008.12.003
- Chu YC, Guan Y, Skinner J, Raja SN, Johns RA, Tao YX. Effect of genetic knockout or pharmacologic inhibition of neuronal nitric oxide synthase on complete Freund's adjuvant-induced persistent pain. Pain. 2005;119:113-213 https://doi.org/10.1016/j.pain.2005.09.024
- Meller ST, Cummings CP, Traub RJ, Gebhart GF. The role of nitric oxide in the development and maintenance of the hyperalgesia produced by intraplantar injection of carrageenan in the rat. Neuroscience. 1994;60:367-374. https://doi.org/10.1016/0306-4522(94)90250-X
- Chung E, Burke B, Bieber AJ, Doss JC, Ohgami Y, Quock RM. Dynorphin-mediated antinociceptive effects of L-arginine and SIN-1 (an NO donor) in mice. Brain Res Bull. 2006;70:245-250. https://doi.org/10.1016/j.brainresbull.2006.05.008
- Durate ID, Lorenzetti BB, Ferreira SH. Peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur J Pharmacol. 1990;186:289-293. https://doi.org/10.1016/0014-2999(90)90446-D
-
Bao L, Avshalumov M, Rice ME. Partial mitochondrial inhibition causes striatal dopamine release suppression and medium spiny neuron depolarization via
$H_2O_2$ elevation, not ATP depletion. J Neurosci. 2005;25:10029-10040. https://doi.org/10.1523/JNEUROSCI.2652-05.2005 - Avshalumov MV, Chen BT, Koos T, Rice ME. Endogenous hydrogen peroxide regulates the excitability of midbrain dopamine neurons via ATP-sensitive potassium channels. J Neurosci. 2005;25:4222-4231. https://doi.org/10.1523/JNEUROSCI.4701-04.2005
- Takahashi A, Mikami M, Yang J. Hydrogen peroxide increases GABAergic mIPSC through presynaptic release of calcium from IP3receptor-sensitive stores in spinal cord substantia gelatinosa neurons. European J Neurosci. 2007;25:705-716. https://doi.org/10.1111/j.1460-9568.2007.05323.x
- Son Y, Chun SW. Effects of hydrogen peroxide on neuronal excitability and synaptic transmission in rat substantia gelatinosa neurons. Int J Oral Biol.. 2007;32:153-160.
- Ahern GP, Klyachko VA, Jackson MB. cGMP and S-nitrosylation : two routes for modulation of neuronal excitability by NO. Trends Neurosci. 2002;25:510-517. https://doi.org/10.1016/S0166-2236(02)02254-3
- Li Z, Ji G, Neugebauer V. Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. J Neurosci. 2011;31:1114-1127. https://doi.org/10.1523/JNEUROSCI.5387-10.2011
- Hawkins BJ, Madesh M, Kirkpatrick CJ, Fisher AB. Superoxide flux in endothelial cells via the chloride channel-3 mediates intracellular signaling. Biol Cell. 2007;18:2002-2012.
- Droge W. Free radicals in the physiological control of cell function. Physiol Rev. 2002;82:47-95.
- Schwartz ES, Lee I, Chung K, Chung JM. Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain. 2008;138:514-524. https://doi.org/10.1016/j.pain.2008.01.029
- Kim HK, Kim JH, Gao X, Zhou JL, Lee I, Chung K, Chung JM. Analgesic effect of vitamin E is mediated by reducing central sensitization in neuropathic pain. Pain. 2006;122:53-62. https://doi.org/10.1016/j.pain.2006.01.013
- Sato E, Mokudai T, Niwano Y, Kohno M. Kinetic analysis of reactive oxygen species generated by the in vitro reconstituted NADPH oxidase and xanthine oxidase systems. J Biochem. 2011;150:173-181. https://doi.org/10.1093/jb/mvr051
- Zhou X, Wen K, Yuan D, Ai L, He P. Calcium influx-dependent differential actions of superoxide and hydrogen peroxide on microvessel permeability. Am J Physiol Heart Circ Physiol. 2009;296:H1096-1107. https://doi.org/10.1152/ajpheart.01037.2008
- Li K, Qi WX. Effects of multiple intrathecal administration of L-arginine with different doses on formalin-induced nociceptive behavioral responses in rats. Neurosci Bull. 2010;26:211-218. https://doi.org/10.1007/s12264-010-0127-9
- Kawabata A, Manabe S, Manabe Y, Takagi H. Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. Br J Pharmacol. 1994;112:547-550. https://doi.org/10.1111/j.1476-5381.1994.tb13108.x
- Pehl U, Schmid HA. Electrophysiological responses of neurons in the rat spinal cord to nitric oxide. Neuroscience. 1997;77:563-573. https://doi.org/10.1016/S0306-4522(96)00495-2
- Kotake Y. Pharmnacologic properties of phenyl N-tert-butylnitrone. Antioxid Redox Signal. 1999;1:481-499. https://doi.org/10.1089/ars.1999.1.4-481
- Tal M. A novel antioxidant alleviates heat hyperalgesia in rats with an experimental painful peripheral neuropathy. Neuroreport. 1996;7:1382-1384. https://doi.org/10.1097/00001756-199605310-00010
- Tanabe S, Wang X, Takahashi N, Uramoto H, Okada Y. HCO(3)(-)-independent rescue from apoptosis by stilbene derivatives in rat cardiomyocytes. FEBS Lett. 2005;579:517-522. https://doi.org/10.1016/j.febslet.2004.12.020
- Finkel T. Oxidant signals and oxidative stress. Curr Opin Cell Biol. 2003;15:247-254. https://doi.org/10.1016/S0955-0674(03)00002-4
- Brzezinska AK, Lohr N, Chilian WM. Electrophysiological effects of O2˙- on the plasma membrane in vascular endothelial cells. Am J Physiol Heart Circ Physiol. 2005;289:H2379-2386. https://doi.org/10.1152/ajpheart.00132.2005
- Kawano T, Zoga V, Kimura M, Liang MY, Wu HE, Gemes G, McCallum JB, Kwok WM, Hogan QH, Sarantopoulos CD. Nitric oxide activates ATP-sensitive potassium channels in mammalian sensory neurons: action by direct S-nitrosylation. Mol Pain. 2009;14:5-112.
- Sousa AM, Prado WA. The dual effect of a nitric oxide donor in nociception. Brain Res. 2001;897:9-19. https://doi.org/10.1016/S0006-8993(01)01995-3
-
Nishida M, Maruyama Y, Tanaka R, Kontani K, Nagao T, Kurose H. G
${\alpha}$ i and G${\alpha}$ o are target proteins of reactive oxygen species. Nature. 2000;408:492-495. https://doi.org/10.1038/35044120 - Giniatullin AR, Grishin SN, Sharifullina ER, Petrov AM, Zefirov AL, Giniatullin RA. Reactive oxygen species contribute to the presynaptic action of extracellular ATP at the frog neuromuscular junction. J Physiol. 2005;565:229-242. https://doi.org/10.1113/jphysiol.2005.084186
- Mason HS, Bourke S, Kemp PJ. Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. Mol Pharmacol. 2004;66:1525-1535. https://doi.org/10.1124/mol.104.000851
-
Andrea P, Romanello M, Massimiliano B, Steinberg TH, Tell G.
$H_2O_2$ modulates purinergic-dependent calcium signalling in osteoblast-like cells. Cell Calcium. 2008;43:457-468. https://doi.org/10.1016/j.ceca.2007.07.007