Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Real-time Detection of Trace Copper in Brain and Kidney of Fish for Medical Diagnosis

  • Yang, Young Kyun (Department of Basic Education, Seoul National University of Technology) ;
  • Pack, Eun Chul (Department of Public Health Science, Graduate School, Korea University) ;
  • Lee, Seung Ha (Department of Public Health Science, Graduate School, Korea University) ;
  • Yoo, Hai-Soo (Korea Ocean R&D Institute) ;
  • Choi, Dal Woong (Department of Public Health Science, Graduate School, Korea University) ;
  • Ly, Suw Young (Biosensor Research Institute)
  • Received : 2014.11.12
  • Accepted : 2014.12.26
  • Published : 2014.12.31
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Abstract

For the detection of trace copper to be used in medical diagnosis, a sensitive handmade carbon nanotube paste electrode (PE) was developed using voltammetry. Analytical optimized conditions were found at 0.05 V anodic peak current. In the same conditions, various common electrodes were compared using stripping voltammetry, and the PE was found to be more sharply sensitive than other common electrodes. At optimum conditions, the working ranges of $3{\sim}19{\mu}gL^{-1}$ were obtained. The relative standard deviation of $70.0{\mu}gL^{-1}$ was determined to be 0.117% (n = 15), and the detection limit (S/N) was found to be $0.6{\mu}gL^{-1}$ ($9.4{\times}10^{-9}M$). The results were applied in detecting copper traces in the kidney and the brain cells of fish.

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References

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