Korean Circulation Journal

The Korean Society of Cardiology (대한심장학회)
권호 표지
DOI QR코드

DOI QR Code

Beyond Vasodilator: Anti-Apoptotic Effect of Endothelin Receptor Antagonist

  • Chang, Sung-A (Division of Cardiology, Department of Medicine, Cardiovascular Imaging Center, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Published : 2014.02.28
⟨ Previous Next ⟩

Abstract

Keywords

References

  1. Channick RN, Simonneau G, Sitbon O, et al. Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 2001;358:1119-23. https://doi.org/10.1016/S0140-6736(01)06250-X
  2. Galie N, Rubin Lj, Hoeper M, et al. Treatment of patients with mildly symptomatic pulmonary arterial hypertension with bosentan (EARLY study): a double-blind, randomised controlled trial. Lancet 2008;371:2093-100. https://doi.org/10.1016/S0140-6736(08)60919-8
  3. Rubin LJ. Endothelin receptor antagonists for the treatment of pulmonary artery hypertension. Life Sci 2012;91:517-21. https://doi.org/10.1016/j.lfs.2012.07.033
  4. Sitbon O, Morrell N. Pathways in pulmonary arterial hypertension: the future is here. Eur Respir Rev 2012;21:321-7. https://doi.org/10.1183/09059180.00004812
  5. Malenfant S, Neyron AS, Paulin R, et al. Signal transduction in the development of pulmonary arterial hypertension. Pulm Circ 2013;3:278-93. https://doi.org/10.4103/2045-8932.114752
  6. Hong YM, Kwon JH, Choi S, Kim KC. Apoptosis and inflammation associated gene expressions in monocrotaline-induced pulmonary hypertensive rats after bosentan treatment. Korean Circ J 2014;44:97-104. https://doi.org/10.4070/kcj.2014.44.2.97
  7. Gong S, Peng L, Yan B, et al. Bosentan reduces neuronal apoptosis following spinal cord ischemic reperfusion injury. Spinal Cord 2013. [Epub ahead of print]
  8. Bien S, Riad A, Ritter CA, et al. The endothelin receptor blocker bosentan inhibits doxorubicin-induced cardiomyopathy. Cancer Res 2007;67:10428-35. https://doi.org/10.1158/0008-5472.CAN-07-1344
  9. Peduto Eberl L, Bovey R, Juillerat-Jeanneret L. Endothelin-receptor antagonists are proapoptotic and antiproliferative in human colon cancer cells. Br J Cancer 2003;88:788-95. https://doi.org/10.1038/sj.bjc.6600810