Korean Circulation Journal

  • 제44권5호
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  • Pages.355-357
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  • 2014
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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Prasugrel-Induced Hypersensitivity Skin Reaction

  • Kim, Soo-Han (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Park, Sang-Don (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Baek, Yong-Soo (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Lee, Seon-Young (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Shin, Sung-Hee (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Woo, Sung-Il (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Kim, Dae-Hyeok (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine) ;
  • Kwan, Jun (Division of Cardiology, Department of Internal Medicine, Inha University College of Medicine)
  • 투고 : 2013.08.21
  • 심사 : 2013.10.08
  • 발행 : 2014.05.30
⟨ 이전 논문 다음 논문 ⟩

초록

We report a case of hypersensitivity skin reaction to prasugrel. The patient exhibited a generalized skin rash after treatment with prasugrel, which was resolved after discontinuation of prasugrel and substitution to clopidogrel. Clopidogrel was successfully administered as an alternative to prasugrel without any signs of further hypersensitivity.

키워드

참고문헌

  1. Wiviott SD, Braunwald E, McCabe C, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357: 2001-15. https://doi.org/10.1056/NEJMoa0706482
  2. Deshmukh AJ, Pant S, Cook J, Sachdeva R, Rutlen D, Uretsky BF. Prasugrel- induced rash. Ann Pharmacother 2012;46:1123-5. https://doi.org/10.1345/aph.1R062
  3. Lokhandwala J, Best PJ, Henry Y, Berger PB. Allergic reactions to clopidogrel and cross-reactivity to other agents. Curr Allergy Asthma Rep 2011;11:52-7. https://doi.org/10.1007/s11882-010-0152-9
  4. Lokhandwala JO, Best PJ, Butterfield JH, et al. Frequency of allergic or hematologic adverse reactions to ticlopidine among patients with allergic or hematologic adverse reactions to clopidogrel. Circ Cardiovasc Interv 2009;2:348-51. https://doi.org/10.1161/CIRCINTERVENTIONS.108.832964.108.832964
  5. Mehta SR, Yusuf S, Peters RJ, et al. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet 2001;358:527-33. https://doi.org/10.1016/S0140-6736(01)05701-4
  6. Bertrand ME, Legrand V, Boland J, et al. Randomized multicenter comparison of conventional anticoagulation versus antiplatelet therapy in unplanned and elective coronary stenting. The full anticoagulation versus aspirin and ticlopidine (fantastic) study. Circulation 1998;98: 1597-603. https://doi.org/10.1161/01.CIR.98.16.1597
  7. Mutnick JL. Desensitization to prasugrel: cardiology's increased need for allergy consultation. Ann Allergy Asthma Immunol 2012;108:124-5. https://doi.org/10.1016/j.anai.2011.11.005
  8. Cheema AN, Mohammad A, Hong T, et al. Characterization of clopidogrel hypersensitivity reactions and management with oral steroids without clopidogrel discontinuation. J Am Coll Cardiol 2011;58:1445-54. https://doi.org/10.1016/j.jacc.2011.06.040

피인용 문헌

  1. Prasugrel : Hypersensitivity skin reaction: case report vol.1526, pp.1, 2014, https://doi.org/10.1007/s40278-014-4759-9
  2. Comparing Allergist and Cardiologist Considerations for the Optimal Management of Thienopyridines Hypersensitivity vol.19, pp.1, 2014, https://doi.org/10.2174/1871530318666180914121758
  3. Drug eruption due to prasugrel hydrochloride: A case report and mini‐review vol.46, pp.9, 2019, https://doi.org/10.1111/1346-8138.14856
  4. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs vol.8, pp.9, 2020, https://doi.org/10.1016/j.jaip.2020.08.006