Korean Circulation Journal

  • 제44권4호
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  • Pages.268-270
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  • 2014
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  • 1738-5520(pISSN)
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  • 1738-5555(eISSN)
대한심장학회 (The Korean Society of Cardiology)
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DOI QR코드

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Potential Inherited Causes of Recurrent Prosthetic Mitral Valve Thrombosis in a Pregnant Patient Suffering from Recurrent Miscarriage

  • Kalcik, Macit (Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital) ;
  • Gursoy, M. Ozan (Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital) ;
  • Karakoyun, Suleyman (Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital) ;
  • Yesin, Mahmut (Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital) ;
  • Astarcioglu, Mehmet Ali (Department of Cardiology, Kosuyolu Kartal Heart and Research Hospital) ;
  • Ozkan, Mehmet (Department of Cardiology, Faculty of Medicine, Kars Kafkas University)
  • 투고 : 2014.01.03
  • 심사 : 2014.03.25
  • 발행 : 2014.04.30
⟨ 이전 논문 다음 논문 ⟩

초록

An effective anticoagulation is critical in pregnant patients with prosthetic heart valves. Inherited disorders may interfere with the coagulation cascade and may be associated with obstetrical complications as well as with prosthetic valve-derived complications. The patient in the present case had a history of recurrent prosthetic heart valve thrombosis (PHVT) despite an effective anticoagulation. She underwent a thrombolysis with low-dose prolonged infusion of tissue-type plasminogen activator for the management of her recurrrent prosthetic valve thrombosis. The genetic testing showed homozygous mutations of methylenetetrahydrofolate reductase (MTHFR) A 1298 C and heterozygous mutations of ${\beta}$-fibrinogen 455 G-A. Inherited disorders such as MTHFR A 1298 C and fibrinogen 455G/A polymorphisms may be involved in the pathogenesis of recurrent PHVT and/or pregnancy loss.

키워드

참고문헌

  1. Chan WS, Anand S, Ginsberg JS. Anticoagulation of pregnant women with mechanical heart valves: a systematic review of the literature. Arch Intern Med 2000;160:191-6. https://doi.org/10.1001/archinte.160.2.191
  2. D'Uva M, Micco PD, Strina I, Placido GD. Recurrent pregnancy loss and thrombophilia. J Clin Med Res 2010;2:18-22.
  3. Ozkan M, Gunduz S, Biteker M, et al. Comparison of different TEEguided thrombolytic regimens for prosthetic valve thrombosis: the TROIA trial. JACC Cardiovasc Imaging 2013;6:206-16. https://doi.org/10.1016/j.jcmg.2012.10.016
  4. Ozkan M, Cakal B, Karakoyun S, et al. Thrombolytic therapy for the treatment of prosthetic heart valve thrombosis in pregnancy with low-dose, slow infusion of tissue-type plasminogen activator. Circulation 2013;128:532-40. https://doi.org/10.1161/CIRCULATIONAHA.113.001145
  5. Ozkan M, Biteker M, Duran NE, Yildiz M. Images in cardiovascular medicine. Huge prosthetic mitral valve thrombosis in a pregnant woman. Circulation 2009;120:e151-2. https://doi.org/10.1161/CIRCULATIONAHA.109.873786
  6. Brenner B. Haemostatic changes in pregnancy. Thromb Res 2004;114:409-14. https://doi.org/10.1016/j.thromres.2004.08.004
  7. James AH, Jamison MG, Brancazio LR, Myers ER. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol 2006;194:1311-5. https://doi.org/10.1016/j.ajog.2005.11.008
  8. Spiroski I, Kedev S, Antov S, et al. Methylenetetrahydrofolate reductase (MTHFR-677 and MTHFR-1298) genotypes and haplotypes and plasma homocysteine levels in patients with occlusive artery disease and deep venous thrombosis. Acta Biochim Pol 2008;55:587-94.
  9. Kim SY, Park SY, Choi JW, et al. Association between MTHFR 1298A>C polymorphism and spontaneous abortion with fetal chromosomal aneuploidy. Am J Reprod Immunol 2011;66:252-8. https://doi.org/10.1111/j.1600-0897.2011.00996.x
  10. Bozdemir V, Kirimli O, Akdeniz B, et al. The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anadolu Kardiyol Derg 2010;10:209-15. https://doi.org/10.5152/akd.2010.059
  11. Weng X, Cloutier G, Genest J Jr. Contribution of the -455G/A polymorphism at the beta-fibrinogen gene to erythrocyte aggregation in patients with coronary artery disease. Thromb Haemost 1999;82:1406-11.

피인용 문헌

  1. Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations vol.17, pp.3, 2014, https://doi.org/10.1080/17434440.2020.1733972
  2. Neutrophil and Neutrophil-to-Lymphocyte Ratio as Clinically Predictive Risk Markers for Recurrent Pregnancy Loss vol.28, pp.4, 2014, https://doi.org/10.1007/s43032-020-00388-z