대한의생명과학회지 (Biomedical Science Letters)

  • 제19권2호
  • /
  • Pages.168-172
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  • 2013
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지

(E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine inhibits Inducible Nitric Oxide Synthase Expression in RAW264.7 Macrophages Stimulated with Lipopolysaccharide

  • Gu, Gyo-Jeong (Department of Medical Science, College of Medical Sciences, SoonChunHyang University) ;
  • Eom, Sang-Hoon (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Suh, Chang Won (Department of Chemistry, College of Natural Sciences, Soonchunhyang University) ;
  • Koh, Kwang Oh (Department of Chemistry, College of Natural Sciences, Soonchunhyang University) ;
  • Kim, Dae Young (Department of Chemistry, College of Natural Sciences, Soonchunhyang University) ;
  • Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, SoonChunHyang University)
  • 투고 : 2013.03.11
  • 심사 : 2013.04.06
  • 발행 : 2013.06.29
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초록

Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. TLR4 has been identified as the receptor for lipopolysaccharide (LPS), which is a cell wall component of gram-negative bacteria. The activation of TLR4 signaling by LPS leads to the activation of NF-${\kappa}B$ and the expression of pro-inflammatory gene products such as cytokines, inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2). To evaluate the therapeutic potential of (E)-1-(2-(2-nitrovinyl)phenyl)pyrrolidine (NVPP), previously synthesized in our laboratory, NF-${\kappa}B$ activation and iNOS and COX-2 expression induced by LPS were examined. NVPP inhibited the activation of NF-${\kappa}B$ induced by LPS. NVPP also suppressed the iNOS expression induced by LPS but it did not suppress COX-2 expression induced by LPS. These results suggest that NVPP has the specific mechanism for anti-inflammatory responses.

키워드

참고문헌

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