대한의생명과학회지 (Biomedical Science Letters)

  • 제19권2호
  • /
  • Pages.147-152
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  • 2013
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  • 1738-3226(pISSN)
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  • 2288-7415(eISSN)
대한의생명과학회 (The Korean Society for Biomedical Laboratory Sciences)
권호 표지

Inhibitory Effects of Curcuminoids on $17{\beta}$-hydroxysteroid Dehydrogenase Type 1 Activity in Animal Livers

  • Lee, Sung-Eun (Division of Applied Biosciences, Kyungpook National University) ;
  • Park, Byeoung-Soo (Research Station, Nanotoxtech Inc.) ;
  • Kim, Hye Jin (Department of Dental Hygiene, College of Nursing and Healthcare Sciences, Dong-eui University) ;
  • Lee, Eun-Woo (Department of Life Science and Biotechnology, College of Natural Sciences, Dong-eui University) ;
  • Yum, Jong Hwa (Department of Clinical Laboratory Science, College of Nursing and Healthcare Sciences)
  • 투고 : 2013.04.26
  • 심사 : 2013.05.30
  • 발행 : 2013.06.29
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초록

17-${\beta}$-hydroxysteroid dehydrogenase type 1 ($17{\beta}$-HSD type 1) mediates the reaction of $17{\beta}$-estradiol (E2) production from estrone (E1). Inhibitory effects of curcuminoids on $17{\beta}$-HSD type 1 activity were investigated to find a lead compound for treating estrogen-dependent diseases including breast cancer. Among curcuminoids, demethoxycurcumin showed potent inhibitory effect ($IC_{50}=2.7{\mu}M$) on mouse $17{\beta}$-HSD type 1. Curcuminoids also displayed their inhibitory effects on the production of $17{\alpha}$-estradiol which is a carcinogenic metabolite produced by the enzyme. Bisdemethoxycurcumin ($IC_{50}=1.3{\mu}M$) showed potent inhibitory effect on the $17{\alpha}$-estradiol production by chicken $17{\beta}$-HSD type 1. Curcuminoids did not inhibit ERE transcriptional activity with and without E2. Taken together, curcuminoids can be used for treating and preventing E2-dependent diseases via inhibition on $17{\beta}$-HSD type 1 activity.

키워드

참고문헌

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