Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Triptolide Suppresses the Expression of Cyclooxygenase-2 Induced by Toll-Like Receptor 3 and 4 Agonists

  • Gu, Gyo-Jeong (Department of Medical Science, College of Medical Sciences, SoonChunHyang University) ;
  • Eom, Sang-Hoon (Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University) ;
  • Min, In Soon (Department of Healthcare Administration and Management, College of Medical Sciences, SoonChunHyang University) ;
  • Youn, Hyung-Sun (Department of Medical Science, College of Medical Sciences, SoonChunHyang University)
  • Received : 2013.03.11
  • Accepted : 2013.06.07
  • Published : 2013.06.29
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Abstract

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and regulate the activation of innate immunity. All TLR signaling pathways culminate in the activation of NF-${\kappa}B$, leading to the induction of inflammatory gene products such as cyclooxygenase-2 (COX-2). Triptolide (TP), a natural component of Tripterygium wilfordii Hook. F, has been used as folk remedies to treat many chronic diseases for many years. In the present report, we present biochemical evidence that TP inhibits the NF-${\kappa}B$ activation induced by polyriboinosinic polyribocytidylic acid (Poly[I:C], TLR3 agonist) and lipopolysaccharide (LPS, TLR4 agonist). TP also inhibits COX-2 expression induced by Poly[I:C] and LPS. These results suggest that TP can modulate the immune responses regulated by TLR3 and TLR4 signaling pathways.

Keywords

References

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