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The usefulness of the contrast agent high in gadolinium for the contrast-enhanced magnetic resonance hip arthrography

고관절의 자기공명관절조영검사 시 가돌리늄 함유량이 높은 조영제의 유용성

  • Choi, Kwan-Woo (Department of Health Science, Graduate School Hanyang University) ;
  • Kim, Yoon-Shin (Department of Health Science, Graduate School Hanyang University) ;
  • Son, Soon-Yong (Department of Radiology, Asan Medical Center) ;
  • Lee, Ho-Beom (Department of Radiology, Asan Medical Center) ;
  • Na, Sa-Ra (Department of Radiology, Asan Medical Center) ;
  • Min, Jung-Whan (Department of Radiology, Shin-Gu University) ;
  • Yoo, Beong-Gyu (Department of Radiotechnology, Wonkwang Health Science University) ;
  • Lee, Jong-Seok (Department of Radiotechnology, Wonkwang Health Science University)
  • 최관우 (한양대학교 대학원 보건학과) ;
  • 김윤신 (한양대학교 대학원 보건학과) ;
  • 손순룡 (서울아산병원 영상의학과) ;
  • 이호범 (서울아산병원 영상의학과) ;
  • 나사라 (서울아산병원 영상의학과) ;
  • 민정환 (신구대학교 방사선과) ;
  • 유병규 (원광보건대학교 방사선과) ;
  • 이종석 (원광보건대학교 방사선과)
  • Received : 2013.07.30
  • Accepted : 2013.11.07
  • Published : 2013.11.30

Abstract

The purpose of this study is to maximize diagnositc usefulness with increasing signal to noise ratio(SNR) and contrast to noise ratio(CNR) by using a 1mmol/mL gadolinium contrast agent. From January 2012 to June 2013 fourty-seven patients were underwent the MRI scanning to investigate the contrast difference in gadolinium content. Twenty of the patients were injencted the commercial contrast agent containing 0.5mmol/mL gadolinium and the rest of them were injected the new contrast agent containing 1mmol/mL gadolinium called gadobutrol. We measured and evaluated each SNR and CNR of the hip joint space, iliopsoas muscle and femoral head. As a result, using the 1mmol/mL gadolinium contrast agent had the higher SNR results than using the 0.5mmol/mL agent(27% in the hip joint, 30.01% in the femoral head). Also CNR using the 1mmol/mL gadolinium agent was proved to be higher than that of using 0.5mmol/mL agent(28.31% in the ilopsoas muscle and 26.74% in the femoral head). Therefore, the contrast agent containing more gadolinium like 1mmol/mL used in this study is more effective to shorten T1 relaxation time, so it increases the signal intensity and CNR and furthermore maximizes diagnostic value. This study reports the usefulness of the 1mmol/mL contrast agent in the contrast-enhanced magnetic resonance hip arthrography for the first. Therefore, it can be considered to have an meaningful academic value as showing the method for increasing the diagnostic usefulness by using the 1mmol/mL contrast agent.

본 연구는 고관절의 자기공명관절조영검사 시 가돌리늄 함유량이 높은 1mmol/mL 조영제를 사용함으로써 현재 대다수의 의료기관에서 사용하고 있는 0.5mmol/ml 조영제 대비 신호대잡음비와 대조도대잡음비를 높여 진단적 가치를 극대화 시키는데 목적을 두었다. 연구방법은 2012년 1월부터 2013년 6월까지 가돌리늄 함유량에 따른 대조도 차이를 알아보기 위하여 0.5mmol/mL 함유량을 가진 기존의 조영제를 사용한 20명과 1mmol/mL 함유량을 가진 새로운 조영제를 사용한 27명 등 총 47명의 환자를 연구대상으로 하였으며, 고관절의 관절공간과 인접한 근육조직인 장요근, 그리고 대퇴골두의 신호강도를 각각 측정한 후 신호대잡음비와 대조도대잡음비를 비교 평가하였다. 연구 결과, 가돌리늄 함유량이 높은 1mmol/mL 조영제 사용 시 SNR은 관절공간 27.00%(p<.01), 대퇴골두 30.01%(p<.01), 장요근 18.74%(p>.05) 높았고, 대조도대잡음비 또한 신호대잡음비와 같이 관절공간과 장요근, 관절공간과 대퇴골두 모두 28.31%(p<.01)와 26.74%(p<.01)로 높았다. 결론적으로 단위 부피당 가돌리늄 함유량이 높은 1mmol/mL 조영제를 사용하면 높은 T1 단축효과로 인해 신호강도가 커지고 대조도 차이가 큰 영상을 획득 할 수 있어, 진단적 가치가 높은 영상을 얻을 수 있다. 본 연구는 고관절의 자기공명관절조영검사에 대한 1mmol/mL 조영제의 유용성을 최초로 증명하여 진단적 가치를 높일 수 있는 방안을 제시하였다는 데에 학문적 가치가 크다고 하겠다.

Keywords

Acknowledgement

Supported by : 원광보건대학교

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