The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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Effect of ECQ on Iodoacetamide-Induced Chronic Gastritis in Rats

  • Lee, Se Eun (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Song, Hyun Ju (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Park, Sun Young (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Nam, Yoonjin (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Min, Chang Ho (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Lee, Do Yeon (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Jeong, Jun Yeong (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Ha, Hyun Su (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Kim, Hyun-Jung (Department of Pharmacology, College of Pharmacy, Chung-Ang University) ;
  • Whang, Wan Kyun (Department of Pharmacognosy, College of Pharmacy, Chung-Ang University) ;
  • Jeong, Ji Hoon (Department of Pharmacology, School of Medicine, Chung-Ang University) ;
  • Kim, In Kyeom (Department of Pharmacology, School of Medicine, Kyungpook National University) ;
  • Kim, Hak Rim (Department of Pharmacology, College of Medicine, Dankook University) ;
  • Min, Young Sil (Department of Medicinal Plant Science, College of Science and Engineering, Jungwon University) ;
  • Sohn, Uy Dong (Department of Pharmacology, College of Pharmacy, Chung-Ang University)
  • Received : 2013.09.06
  • Accepted : 2013.09.17
  • Published : 2013.10.30
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Abstract

This study investigated effect of extract containing quercetin-3-O-${\beta}$-D-glucuronopyranoside from Rumex Aquaticus Herba (ECQ) against chronic gastritis in rats. To produce chronic gastritis, the animals received a daily intra-gastric administration of 0.1 ml of 0.15% iodoacetamide (IA) solution for 7 days. Daily exposure of the gastric mucosa to IA induced both gastric lesions and significant reductions of body weight and food and water intake. These reductions recovered with treatment with ECQ for 7 days. ECQ significantly inhibited the elevation of the malondialdehyde levels and myeloperoxidase activity, which were used as indices of lipid peroxidation and neutrophil infiltration. ECQ recovered the level of glutathione, activity of superoxide dismutase (SOD), and expression of SOD-2. The increased levels of total NO concentration and iNOS expression in the IA-induced chronic gastritis were significantly reduced by treatment with ECQ. These results suggest that the ECQ has a therapeutic effect on chronic gastritis in rats by inhibitory actions on neutrophil infiltration, lipid peroxidation and various steps of reactive oxygen species (ROS) generation.

Keywords

References

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