Current Research on Agriculture and Life Sciences
- Volume 31 Issue 3
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- Pages.165-169
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- 2013
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- 2287-271X(pISSN)
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- 2288-0356(eISSN)
Anti-oxidant and Anti-inflammatory Effects of Rutin and Its Metabolites
- Kim, Ji Hye (School of Food Science and Biotechnology, Kyungpook National University) ;
- Park, Sang Hee (School of Food Science and Biotechnology, Kyungpook National University) ;
- Beak, Eun Ji (School of Food Science and Biotechnology, Kyungpook National University) ;
- Han, Chang Hee (School of Food Science and Biotechnology, Kyungpook National University) ;
- Kang, Nam Joo (School of Food Science and Biotechnology, Kyungpook National University)
- Received : 2013.06.20
- Accepted : 2013.09.30
- Published : 2013.09.30
Abstract
Rutin is one of the major flavonoids found in buckwheat (Fagopyrum esculentum Moench). While rutin is already known to exhibit anti-oxidative, anti-inflammatory, and anti-carcinogenic activities. However, the health beneficial function of rutin metabolites is not well understood. In DPPH radical scavenging assays, the present study found that 3,4-dihydroxyphenyl acetic acid had the highest total anti-oxidant activity, followed by 3,4-dihydroxyphenylacetic acid, rutin, homovanillic acid, and 3-hydroxyphenyl acetic acid. Further, 3,4-dihydroxyphenylacetic acid strongly reduced LPS-induced IL-6 production in RAW 264.7 cells, compared with other metabolites. Therefore, these results suggest that rutin metabolites have potential to be utilized as food ingredients with anti-oxidant and anti-inflammatory activities.