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The Evaluation of Cerebral Executive Function Using Functional MRI

기능적 자기공명영상기법을 이용한 대뇌의 집행기능 평가

  • Received : 2013.07.18
  • Accepted : 2013.10.25
  • Published : 2013.10.30

Abstract

This study involves an experiment using functional magnetic resonance imaging(fMRI) to delineate brain activation for execution functional performance. Participates to this experiment of the normal adult (man 4, woman 6) of 10 people, is not inserts the metal all closed phobia and 24.5 year-old average ages which the operating surgeon experience which are not they were. The subject for a functional MRI experiment word -color test prosecuting attorney subject rightly at magnetic pole presentation time of 30 first editions and after presenting, uses SPM 99 programs and the image realignment, after executing a standardization (nomalization), a difference which the signal burglar considers the timely order as lattice does, pixel each image will count there probably is, in order to examine rest and active crossroad dividing independence sample t-test (p<.05). Overlapped in this standard anatomic image and got a brain activation image from level of significance 95%. With functional MRI resultant execution function inside being relation, the prefrontal lobe, anterior cingulate gyrus, parietal lobe, orbitofrontal gyrus, temporal lobe, parietal lobe was activated. The execution function promotes a recovery major role from occupational therapy, understanding about the damage mechanism is important. When confirms the brain active area which accomplishes an execution function brain plasticity develops the cognitive therapeutic method which is effective increases usefully very, will be used.

집행기능은 뇌손상환자의 회복을 촉진시키는데 중요한 역할을 하며, 그 손상 기전에 대한 이해는 중요하다. 본 연구에서는 기능적 자기공명 영상 기법을 이용하여 집행기능 수행에 관여하는 대뇌 활성화 영역을 파악하고자 실시하였다. 10명의 정상성인(남자 4, 여자 6)이 실험에 참여하였으며, 모두 폐쇄공포증이 없고 금속을 삽입한 수술의 경험이 없는 평균 나이 24.5 세였다. 기능적 자기공명영상 실험을 위한 과제는 단어-색체 검사 과제를 30초간의 자극제시 시간에 맞게 수정하여 제시한 후, SPM 99 프로그램을 이용하여 영상 재정렬(realignment), 표준화(nomalization)를 실시한 후 시간 순서대로 격자화하고, 각 영상 픽셀의 신호강도의 유의한 차이가 있는지를 알아보기 위해 휴지기와 활성기로 나누어 독립표본 t-검정(p<.05)을 실시하여 활성화 영상을 생성시켰다. 이를 표준 해부학적 영상에 중첩시켜 유의수준 95%에서 뇌 활성화 영상을 얻었다. 기능적 자기공명 영상결과 집행기능과 관련 있는 내측 전전두엽, 전 대상회, 두정엽, 시각 전두영역, 측두엽 등에서 활성화 우위를 보였다. 집행기능을 수행하는 뇌 활성화 영역을 확인하면 뇌가소성을 증진시키는 효과적인 인지 치료방법을 개발하는데 매우 유용하게 사용될 것이다.

Keywords

References

  1. Pennington BF, Ozonoff S Executive function and developmental psychopathology. J Child Psychol Psychiatry 37(1), 51-87.1996 https://doi.org/10.1111/j.1469-7610.1996.tb01380.x
  2. Miller BL, Cummings JL. The human frontal lobe : function and disorders. New York, The Guilford Press, 1999
  3. Welsh MC, Pennington BF. Assessing frontal lobe functioning in children : Views from developmental psychology. Developmental Neuropsychology 4, 199-230. 1988 https://doi.org/10.1080/87565648809540405
  4. 이상신, 유병국, 김양태, 김희숙. 안와전두피질의 기능. 생물치료정신의학, 13(1), 36. 2007
  5. Braaten AJ, Parsons TD, McCue R, Sellers A, Burns WJ. Neurocognitive differential diagnosis of dementing diseases: Alzheimer;s Dementia, Vascular Dementia, Frontotemporal Dementia and Major Depressive Disorder. Int J Neurosci, 116(11), 1271-93. 2006 https://doi.org/10.1080/00207450600920928
  6. Graham NL, Emery T, Hodges JR. Distinctive cognitive profiles in Alzheimer;s Dementia, subcortical Vascular Dementia, J Neurol Nuerosurg Psychiatry, 75(1), 61-71. 2004
  7. 최성혜. 혈관성 치매에서의 간단한 인지기능 평가 방법. 대한뇌졸중학회지, 2(2), 126-128. 2000
  8. Looi JCL, Sachdev PS. Differentiation of vascular dementia from AD on neuropsychological tests. Neurology, 53, 670-678. 1999 https://doi.org/10.1212/WNL.53.4.670
  9. Almkvist O. Neuropsychological deficits in vascular dementia in relation to Alzheimer's disease : reviewing the evidence for functional similarity or divergence. Dementia, 5, 203-209. 1994
  10. Denkla MB. Executive function, the overlapzone between attention deficit hyperactivity disorder and learning disabilities. International Pediatrics, 4, 155-160.1989
  11. Erkinjuntti T, Hachinski VC. Vascular dementia : a construct in evolution. Cerebrovasc Dis, 3, 3-23.1993 https://doi.org/10.1159/000108661
  12. Erkinjuntti T. Vascular dementia; challenge of clinical diagnosis. Int Psychogeriatr, 9, 51-58.1997 https://doi.org/10.1017/S1041610297004699
  13. Mungas D, Jagust WJ, Reed BR, Kramer JH, Weiner MW, Schuff N, Norman D, Mack WJ, Willis L, Chui HC. MRI preditors of cognition in subcortical ischemic vascular disease and Alzheimer;s disease, Neurology, 57(12), 229-35.2001
  14. O'Sullivan M, Morris RG, Markus HS. Brief cognitive assessment for patients with cerebral small vessel disease. J Neurol Neurosurg Psychiatry, 76(8), 1140-5.2005 https://doi.org/10.1136/jnnp.2004.045963
  15. 이정애, 신동균, 이창욱, 이민수 정신과 환자 집단의 실행 기능 연구. 신경정신의학, 41(2), 322-334. 2002
  16. Villardita C Alzheimer;s disease compared with cerebrovascular dementia. Neuropsychological similartities and differences. Acta Neurol Scand, 87(4), 299-308.1993 https://doi.org/10.1111/j.1600-0404.1993.tb05512.x