Asian Pacific Journal of Cancer Prevention

  • 제14권6호
  • /
  • Pages.3891-3895
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  • 2013
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Prognostic Significance of α5β1-integrin Expression in Cervical Cancer

  • Wang, Hua-Yi (Department of Oncology, Zhongnan Hospital of Wuhan University) ;
  • Chen, Zhe (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital) ;
  • Wang, Zhu-Hui (Department of Obstetrics and Gynecology, Jingzhou Second People Hospital) ;
  • Wang, Hong (Department of Pathology, Jingzhou Second People Hospital) ;
  • Huang, Li-Ming (Department of Oncology, Zhongnan Hospital of Wuhan University)
  • 발행 : 2013.06.30
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초록

The purpose of this study was to evaluate the association of expression of ${\alpha}5{\beta}1$-integrin with clinicopathologic features and prognosis in cervical cancer. Levels of ${\alpha}5{\beta}1$-integrin in normal cervical mucosa and cervical cancer tissue were detected with immunohistochemistry. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. ${\alpha}5{\beta}1$-integrin expression was detected in 84.6% (143/169) cervical cancer samples, significantly different from that in normal cervical mucosa (P < 0.05). Positive expression rates of ${\alpha}5{\beta}1$-integrin in patients with poor histologic differentiation, lymph node metastasis, and recurrence were elevated. Using Kaplan-Meier analysis, a comparison of survival curves of low versus high expression of ${\alpha}5{\beta}1$-integrin revealed a highly significant difference in human cervical cancer cases (P < 0.05), suggesting that overexpression of ${\alpha}5{\beta}1$-integrin is associated with a worse prognosis.The ${\alpha}5{\beta}1$-integrin promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical cancer. The current study indicated that ${\alpha}5{\beta}1$-integrin may be an independent prognostic factor for cervical cancer patients.

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피인용 문헌

  1. Integrins vol.25, pp.10, 2014, https://doi.org/10.1097/CAD.0000000000000145
  2. Development of the Fibronectin–Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker α5β1 Integrin vol.38, pp.11, 2015, https://doi.org/10.1248/bpb.b15-00344