Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

  • Sun, Jia-Ming (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Li, Qiong (Department of Plastic Surgery, Wuhan Union Hospital, Tongji Medical College of Huazhong University of Science and Technology) ;
  • Gu, Hai-Yong (Department of Cardiothoracic Surgery, Affiliated People's Hospital of Jiangsu University) ;
  • Chen, Yi-Jang (Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University) ;
  • Wei, Ji-Shu (Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University) ;
  • Zhu, Quan (Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University) ;
  • Chen, Liang (Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University)
  • Published : 2013.06.30
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Abstract

Aim: Esophageal cancer is the eighth most common cancer and sixth leading cause of cancer associated death worldwide. The 5 year survival rate for esophageal cancer patients is very poor and accounts for only 12.3%. Besides environmental risk factors, genetic factors might play an important role in the esophageal cancer carcinogenesis. Methods: We conducted a hospital based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs): interleukin 9 (IL9) rs31563 C>T, IL9 rs31564 G>T, IL10 rs1800872 T>G, IL12A rs2243115 T>G, IL12B rs3212227 T>G and IL13 rs1800925 C>T on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan$^{TM}$ Kit. Results: The IL10 rs1800872 T>G polymorphism was associated with an increased risk of ESCC. However, there were no significant links with the other five SNPs. Stratified analyses indicated no significant risk of ESCC associated with the IL10 rs1800872 T>G polymorphism evident among any subgroups. Conclusion: These findings indicated that functional polymorphism IL10 rs1800872 T>G might contribute to ESCC susceptibility. However, our results were obtained with a limited sample size, so that the power of our analysis was low. Future larger studies with more rigorous study designs of other ethnic populations are required to confirm the current findings.

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References

  1. Akdis M (2006). Healthy immune response to allergens: T regulatory cells and more. Curr Opin Immunol, 18, 738-44. https://doi.org/10.1016/j.coi.2006.06.003
  2. Berrino F, De Angelis R, Sant M, et al (2007). Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-99: results of the EUROCARE-4 study. Lancet Oncol, 8, 773-83. https://doi.org/10.1016/S1470-2045(07)70245-0
  3. Chen X, Li S, Yang Y, et al (2012). Genome-wide association study validation identifies novel loci for atherosclerotic cardiovascular disease. J Thromb Haemost, 10, 1508-14. https://doi.org/10.1111/j.1538-7836.2012.04815.x
  4. Couper KN, Blount DG, Riley EM (2008). IL-10: the master regulator of immunity to infection. J Immunol, 180, 5771-7. https://doi.org/10.4049/jimmunol.180.9.5771
  5. Eskdale J, Kube D, Tesch H, Gallagher G (1997) Mapping of the human IL10 gene and further characterization of the 5' flanking sequence. Immunogenetics, 46, 120-8. https://doi.org/10.1007/s002510050250
  6. Goswami R, Kaplan MH (2011). A brief history of IL-9. J Immunol, 186, 3283-8. https://doi.org/10.4049/jimmunol.1003049
  7. Gu H, Ding G, Zhang W, et al (2012). Replication study of PLCE1 and C20orf54 polymorphism and risk of esophageal cancer in a Chinese population. Mol Biol Rep, 39, 9105-11. https://doi.org/10.1007/s11033-012-1782-x
  8. Howell WM, Rose-Zerilli MJ (2007). Cytokine gene polymorphisms, cancer susceptibility, and prognosis. J Nutr, 137, S194-9.
  9. Imagawa Y, Satake K, Kato Y, Tahara H, Tsukuda M (2004). Antitumor and antiangiogenic effects of interleukin 12 gene therapy in murine head and neck carcinoma model. Auris Nasus Larynx, 31, 239-45. https://doi.org/10.1016/j.anl.2004.03.008
  10. Jebreel A, Mistry D, Loke D, et al (2007). Investigation of interleukin 10, 12 and 18 levels in patients with head and neck cancer. J Laryngol Otol, 121, 246-52.
  11. Jemal A, Siegel R, Ward E, et al (2008). Cancer statistics, 2008. CA Cancer J Clin, 58, 71-96. https://doi.org/10.3322/CA.2007.0010
  12. Liu H, Jacobs BS, Liu J, et al (2000). Interleukin-13 sensitivity and receptor phenotypes of human glial cell lines: nonneoplastic glia and low-grade astrocytoma differ from malignant glioma. Cancer Immunol Immunother, 49, 319-24. https://doi.org/10.1007/s002620000110
  13. Macfarlane GJ, Boyle P (1994) The epidemiology of oesophageal cancer in the UK and other European countries. J R Soc Med, 87, 334-7.
  14. Oh SS, Chang SC, Cai L, et al (2010). Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. Int J Cancer, 127, 2169-82. https://doi.org/10.1002/ijc.25214
  15. Parkin DM, Bray F, Ferlay J, Pisani P (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108. https://doi.org/10.3322/canjclin.55.2.74
  16. Shinomiya T, Mori T, Ariyama Y, et al (1999). Comparative genomic hybridization of squamous cell carcinoma of the esophagus: the possible involvement of the DPI gene in the 13q34 amplicon. Genes Chromosomes Cancer, 24, 337-44. https://doi.org/10.1002/(SICI)1098-2264(199904)24:4<337::AID-GCC7>3.0.CO;2-O
  17. Trinchieri G (2003). Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol, 3, 133-46. https://doi.org/10.1038/nri1001
  18. Uyttenhove C, Simpson RJ, Van Snick J (1988). Functional and structural characterization of P40, a mouse glycoprotein with T-cell growth factor activity. Proc Natl Acad Sci U S A, 85, 6934-8. https://doi.org/10.1073/pnas.85.18.6934
  19. Wu C, Hu Z, He Z, Jia W, et al (2011). Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations. Nat Genet, 43, 679-84. https://doi.org/10.1038/ng.849
  20. Yang XR, Pfeiffer RM, Wheeler W, et al (2009). Identification of modifier genes for cutaneous malignant melanoma in melanoma-prone families with and without CDKN2A mutations. Int J Cancer, 125, 2912-7. https://doi.org/10.1002/ijc.24622

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